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		Research article Novel olanzapine analogues presenting a reduced H₁ receptor affinity and retained 5HT_2A/D₂ binding affinity ratio Somayeh Jafari, Marc E Bouillon, Xu-Feng Huang, Stephen G Pyne, Francesca Fernandez-Enright BMC Pharmacology 2012, 12:8 (22 June 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA₁ receptor signalling in rat brain cryosections without affecting global LPA degradation Niina Aaltonen, Marko Lehtonen, Katri Varonen, Gemma Goterris, Jarmo T Laitinen BMC Pharmacology 2012, 12:7 (11 June 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency Paul J Kammermeier BMC Pharmacology 2012, 12:6 (29 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity Thomas A Munro, Loren M Berry, Ashlee Van’t Veer, Cécile Béguin, F Carroll, Zhiyang Zhao, William A Carlezon, Bruce M Cohen BMC Pharmacology 2012, 12:5 (29 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Plasma levels of kappa opioid antagonists in mice following intraperitoneal administration show a strong negative correlation with the prolonged time-course of antagonism, consistent with an irreversible mechanism of action such as receptor desensitisation.
		Research article 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved Robert Davis, Jill Pattison, Janice M Thompson, Ruslan Tiniakov, Karie E Scrogin, Stephanie W Watts BMC Pharmacology 2012, 12:4 (6 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chronic infusion with 5-hydroxytryptamine (5-HT) reduces total peripheral resistance, and this effect is not due to direct arterial mesenteric relaxation since 5-HT receptors present in the superior mesenteric artery are not functional.
		Research article Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors John Cuppoletti, Anthony T Blikslager, Jayati Chakrabarti, Prashant K Nighot, Danuta H Malinowska BMC Pharmacology 2012, 12:3 (3 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comparison of linaclotide with lubiprostone in experimental models of epithelial barrier function and repair suggests that patients with compromised barrier function, such as in irritable bowel syndrome may benefit more from treatment with lubiprostone.
		Research article Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor Aiying Wang, Charles Dorso, Lisa Kopcho, Gregory Locke, Robert Langish, Eric Harstad, Petia Shipkova, Jovita Marcinkeviciene, Lawrence Hamann, Mark S Kirby BMC Pharmacology 2012, 12:2 (4 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Computational models for in-vitro anti-tubercular activity of molecules based on high-throughput chemical biology screening datasets Vinita Periwal, Shireesha Kishtapuram, Open Source Drug Discovery Consortium, Vinod Scaria BMC Pharmacology 2012, 12:1 (31 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Computational methods based on Machine Learning tools and supervised classifiers generate accurate predictive models for virtual high-throughput screens of large libraries of anti-tubercular molecules, allowing prioritization of good candidates for drug discovery.
		Research article The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen Jessica Stahl, Mareike Wohlert, Manfred Kietzmann BMC Pharmacology 2011, 11:12 (14 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A₃adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts Tina C Wan, Dilip K Tosh, Lili Du, Elizabeth T Gizewski, Kenneth A Jacobson, John A Auchampach BMC Pharmacology 2011, 11:11 (31 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A Polyamidoamine (PAMAM) dendrimer conjugated to 64 moieties of a nucleoside agonist binds to the mouse A3 adenosine receptor with enhanced potency and selectivity, and mediates cardioprotective effects in an isolated heart model of ischemia/reperfusion injury.
		Research article Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice Elizabeth Chia, Satomi Kagota, Enoka P Wijekoon, John J McGuire BMC Pharmacology 2011, 11:10 (28 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vasodilatation mediated by protease-activated receptor 2 (PAR2) is retained in a mouse model of Angiotensin-II induced hypertension and mesenteric arterial vascular dysfunction, through a mechanism dependent on the calcium-activated potassium channel SK3.1.
		Research article Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors Jacob D Durrant, J Andrew McCammon BMC Pharmacology 2011, 11:9 (30 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Dexamethasone restrains ongoing expression of interleukin-23p19 in peripheral blood-derived human macrophages Linda Palma, Carla Sfara, Antonella Antonelli, Mauro Magnani BMC Pharmacology 2011, 11:8 (26 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The glucocorticoid analogue dexamethasone reduces the expression of interleukin-23p19 in human monocyte-derived macrophages via a distinct cascade of down-modulation, secondary to the suppression of p38 MAPK activity and likely involving MAPK phosphatase-1 (MKP-1).
		Research article Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells Elizabeth Alli, Vandana B Sharma, Anne-Renee Hartman, Patrick S Lin, Lisa McPherson, James M Ford BMC Pharmacology 2011, 11:7 (19 July 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors Tamaki Hayase BMC Pharmacology 2011, 11:6 (18 July 2011) Abstract \| Full text \| PDF \| PubMed
		Research article A web server for predicting inhibitors against bacterial target GlmU protein Deepak Singla, Meenakshi Anurag, Debasis Dash, Gajendra PS Raghava BMC Pharmacology 2011, 11:5 (6 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A Quantitative Structure Activity Relationship (QSAR) model based on docking energy descriptors predicts potential inhibitors of the Mycobacterium tuberculosis drug target GlmU, that could be used in the development of drugs against tuberculosis.
		Research article Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata BMC Pharmacology 2011, 11:4 (28 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Synthetic analogs of natural curcumin, found in the popular Indian spice turmeric, overcome the compound's low bioavailability and display enhanced chemotherapeutic potential both in vitro and in a mouse model of colorectal carcinogenesis.
		Research article Altered 5-HT_2Creceptor agonist-induced responses and 5-HT_2Creceptor RNA editing in the amygdala of serotonin transporter knockout mice Pablo R Moya, Meredith A Fox, Catherine L Jensen, Justin L Laporte, Helen T French, Jens R Wendland, Dennis L Murphy BMC Pharmacology 2011, 11:3 (7 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knock-out mice for the serotonin transporter (SERT) are impaired in the anxiogenic response induced by serotonin receptor agonists and display an increased editing of the serotonin 5-HT2C receptor RNA compared to wild-type.
		Research article Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro W Dimpfel, JA Hoffmann BMC Pharmacology 2011, 11:2 (21 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The new Parkinson`s disease drug rasagiline and its metabolite aminoindan, affect the glutamate receptor mediated signaling pathway and display dose-dependent neuroprotective activity in the rat hippocampus.
		Research article The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability Olivier Dellis, Pierre Mercier, Christine Chomienne BMC Pharmacology 2011, 11:1 (26 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Boron-oxygen core present in 2-aminoethyl diphenylborinate (2-APB) and other borinate ester analogues is required for the dual potentiation and inhibition of Store-Operated Calcium Entry (SOCE) in leukocyte cell lines.
		Research article Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study Idrian García-García, Carlos A González-Delgado, Carmen M Valenzuela-Silva, Alina Díaz-Machado, Marisol Cruz-Díaz, Hugo Nodarse-Cuní, Orlando Pérez-Pérez, Cimara H Bermúdez-Badell, Joel Ferrero-Bibilonia, Rolando Páez-Meireles, Iraldo Bello-Rivero, Fidel R Castro-Odio, Pedro A López-Saura, for the FarmaPEG Study Group BMC Pharmacology 2010, 10:15 (23 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice Adeline YL Lim, Ignacio Segarra, Srikumar Chakravarthi, Sufyan Akram, John P Judson BMC Pharmacology 2010, 10:14 (15 October 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl₄induced oxidative stress and cellular degeneration in rat liver Polimetla Srilaxmi, Gangadhara Sareddy, Polavarapu kishor, Oruganti Setty, Phanithi Babu BMC Pharmacology 2010, 10:13 (12 October 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells Leilei Tang, Saskia M Bergevoet, Christian Gilissen, Theo de Witte, Joop H Jansen, Bert A van der Reijden, Reinier AP Raymakers BMC Pharmacology 2010, 10:12 (13 September 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia Che-Chuan Wang, Chung-Ching Chio, Ching-Hong Chang, Jinn-Rung Kuo, Ching-Ping Chang BMC Pharmacology 2010, 10:11 (6 September 2010) Abstract \| Full text \| PDF \| PubMed

	All
		Research article Novel olanzapine analogues presenting a reduced H₁ receptor affinity and retained 5HT_2A/D₂ binding affinity ratio Somayeh Jafari, Marc E Bouillon, Xu-Feng Huang, Stephen G Pyne, Francesca Fernandez-Enright BMC Pharmacology 2012, 12:8 (22 June 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA₁ receptor signalling in rat brain cryosections without affecting global LPA degradation Niina Aaltonen, Marko Lehtonen, Katri Varonen, Gemma Goterris, Jarmo T Laitinen BMC Pharmacology 2012, 12:7 (11 June 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency Paul J Kammermeier BMC Pharmacology 2012, 12:6 (29 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity Thomas A Munro, Loren M Berry, Ashlee Van’t Veer, Cécile Béguin, F Carroll, Zhiyang Zhao, William A Carlezon, Bruce M Cohen BMC Pharmacology 2012, 12:5 (29 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Plasma levels of kappa opioid antagonists in mice following intraperitoneal administration show a strong negative correlation with the prolonged time-course of antagonism, consistent with an irreversible mechanism of action such as receptor desensitisation.
		Research article 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved Robert Davis, Jill Pattison, Janice M Thompson, Ruslan Tiniakov, Karie E Scrogin, Stephanie W Watts BMC Pharmacology 2012, 12:4 (6 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chronic infusion with 5-hydroxytryptamine (5-HT) reduces total peripheral resistance, and this effect is not due to direct arterial mesenteric relaxation since 5-HT receptors present in the superior mesenteric artery are not functional.
		Research article Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors John Cuppoletti, Anthony T Blikslager, Jayati Chakrabarti, Prashant K Nighot, Danuta H Malinowska BMC Pharmacology 2012, 12:3 (3 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comparison of linaclotide with lubiprostone in experimental models of epithelial barrier function and repair suggests that patients with compromised barrier function, such as in irritable bowel syndrome may benefit more from treatment with lubiprostone.
		Research article Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor Aiying Wang, Charles Dorso, Lisa Kopcho, Gregory Locke, Robert Langish, Eric Harstad, Petia Shipkova, Jovita Marcinkeviciene, Lawrence Hamann, Mark S Kirby BMC Pharmacology 2012, 12:2 (4 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Computational models for in-vitro anti-tubercular activity of molecules based on high-throughput chemical biology screening datasets Vinita Periwal, Shireesha Kishtapuram, Open Source Drug Discovery Consortium, Vinod Scaria BMC Pharmacology 2012, 12:1 (31 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Computational methods based on Machine Learning tools and supervised classifiers generate accurate predictive models for virtual high-throughput screens of large libraries of anti-tubercular molecules, allowing prioritization of good candidates for drug discovery.
		Research article The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen Jessica Stahl, Mareike Wohlert, Manfred Kietzmann BMC Pharmacology 2011, 11:12 (14 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A₃adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts Tina C Wan, Dilip K Tosh, Lili Du, Elizabeth T Gizewski, Kenneth A Jacobson, John A Auchampach BMC Pharmacology 2011, 11:11 (31 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A Polyamidoamine (PAMAM) dendrimer conjugated to 64 moieties of a nucleoside agonist binds to the mouse A3 adenosine receptor with enhanced potency and selectivity, and mediates cardioprotective effects in an isolated heart model of ischemia/reperfusion injury.
		Research article Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice Elizabeth Chia, Satomi Kagota, Enoka P Wijekoon, John J McGuire BMC Pharmacology 2011, 11:10 (28 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vasodilatation mediated by protease-activated receptor 2 (PAR2) is retained in a mouse model of Angiotensin-II induced hypertension and mesenteric arterial vascular dysfunction, through a mechanism dependent on the calcium-activated potassium channel SK3.1.
		Research article Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors Jacob D Durrant, J Andrew McCammon BMC Pharmacology 2011, 11:9 (30 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Dexamethasone restrains ongoing expression of interleukin-23p19 in peripheral blood-derived human macrophages Linda Palma, Carla Sfara, Antonella Antonelli, Mauro Magnani BMC Pharmacology 2011, 11:8 (26 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The glucocorticoid analogue dexamethasone reduces the expression of interleukin-23p19 in human monocyte-derived macrophages via a distinct cascade of down-modulation, secondary to the suppression of p38 MAPK activity and likely involving MAPK phosphatase-1 (MKP-1).
		Research article Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells Elizabeth Alli, Vandana B Sharma, Anne-Renee Hartman, Patrick S Lin, Lisa McPherson, James M Ford BMC Pharmacology 2011, 11:7 (19 July 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors Tamaki Hayase BMC Pharmacology 2011, 11:6 (18 July 2011) Abstract \| Full text \| PDF \| PubMed
		Research article A web server for predicting inhibitors against bacterial target GlmU protein Deepak Singla, Meenakshi Anurag, Debasis Dash, Gajendra PS Raghava BMC Pharmacology 2011, 11:5 (6 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A Quantitative Structure Activity Relationship (QSAR) model based on docking energy descriptors predicts potential inhibitors of the Mycobacterium tuberculosis drug target GlmU, that could be used in the development of drugs against tuberculosis.
		Research article Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata BMC Pharmacology 2011, 11:4 (28 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Synthetic analogs of natural curcumin, found in the popular Indian spice turmeric, overcome the compound's low bioavailability and display enhanced chemotherapeutic potential both in vitro and in a mouse model of colorectal carcinogenesis.
		Research article Altered 5-HT_2Creceptor agonist-induced responses and 5-HT_2Creceptor RNA editing in the amygdala of serotonin transporter knockout mice Pablo R Moya, Meredith A Fox, Catherine L Jensen, Justin L Laporte, Helen T French, Jens R Wendland, Dennis L Murphy BMC Pharmacology 2011, 11:3 (7 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knock-out mice for the serotonin transporter (SERT) are impaired in the anxiogenic response induced by serotonin receptor agonists and display an increased editing of the serotonin 5-HT2C receptor RNA compared to wild-type.
		Research article Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro W Dimpfel, JA Hoffmann BMC Pharmacology 2011, 11:2 (21 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The new Parkinson`s disease drug rasagiline and its metabolite aminoindan, affect the glutamate receptor mediated signaling pathway and display dose-dependent neuroprotective activity in the rat hippocampus.
		Research article The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability Olivier Dellis, Pierre Mercier, Christine Chomienne BMC Pharmacology 2011, 11:1 (26 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Boron-oxygen core present in 2-aminoethyl diphenylborinate (2-APB) and other borinate ester analogues is required for the dual potentiation and inhibition of Store-Operated Calcium Entry (SOCE) in leukocyte cell lines.
		Research article Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study Idrian García-García, Carlos A González-Delgado, Carmen M Valenzuela-Silva, Alina Díaz-Machado, Marisol Cruz-Díaz, Hugo Nodarse-Cuní, Orlando Pérez-Pérez, Cimara H Bermúdez-Badell, Joel Ferrero-Bibilonia, Rolando Páez-Meireles, Iraldo Bello-Rivero, Fidel R Castro-Odio, Pedro A López-Saura, for the FarmaPEG Study Group BMC Pharmacology 2010, 10:15 (23 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice Adeline YL Lim, Ignacio Segarra, Srikumar Chakravarthi, Sufyan Akram, John P Judson BMC Pharmacology 2010, 10:14 (15 October 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl₄induced oxidative stress and cellular degeneration in rat liver Polimetla Srilaxmi, Gangadhara Sareddy, Polavarapu kishor, Oruganti Setty, Phanithi Babu BMC Pharmacology 2010, 10:13 (12 October 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells Leilei Tang, Saskia M Bergevoet, Christian Gilissen, Theo de Witte, Joop H Jansen, Bert A van der Reijden, Reinier AP Raymakers BMC Pharmacology 2010, 10:12 (13 September 2010) Abstract \| Full text \| PDF \| PubMed
		Research article Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia Che-Chuan Wang, Chung-Ching Chio, Ching-Hong Chang, Jinn-Rung Kuo, Ching-Ping Chang BMC Pharmacology 2010, 10:11 (6 September 2010) Abstract \| Full text \| PDF \| PubMed