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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Tim Sands PhD
Welcome to BMC Pharmacology published by BioMed Central
BMC Pharmacology is an open access journal publishing original peer-reviewed research articles in aspects of the discovery, design, uses, effects, modes of action and metabolism of chemically defined therapeutic and toxic agents.
BMC Pharmacology (ISSN 1471-2210) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus and Google Scholar.
BMC Pharmacology 2009, 9 :15
The neuromuscular blocker rapacuronium decreases the affinity of acetylcholine for all muscarinic receptor subtypes under equilibrium conditions, but increases the rate of acetylcholine binding to muscarinic receptors 1, 3 and 5 at lower concentrations.
BMC Pharmacology 2009, 9 :13
The psychotropic drug spiperone is a novel Wnt inhibitor that blocks canonical Wnt signaling by increasing intracellular calcium levels and is a candidate for use in the management of cancers that have aberrant Wnt signaling.
BMC Pharmacology 2009, 9 :12
A drug delivery vehicle that uses the non-toxic heavy chain of botulinum neurotoxin-A to gain entry to neurons via endocytosis could rescue synapses poisoned by botox, once an effective antidote is found.
Volume 9 Suppl 2
Meeting abstracts
Graz, Austria. 19-21 November 2009
more info ]
Database
BIAdb: A curated database of benzylisoquinoline alkaloids Deepak Singla, Arun Sharma, Jasjit Kaur, Bharat Panwar, Gajendra P S Raghava BMC Pharmacology 2010, 10 :4 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Hypothesis
Targeting ligand-gated ion channels in Neurology and Psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
Matt T Bianchi, Emmanuel J Botzolakis BMC Pharmacology 2010, 10 :3 (2 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole Giulia Ferrari-Toninelli, Giuseppina Maccarinelli, Daniela Uberti, Erich Buerger, Maurizio Memo BMC Pharmacology 2010, 10 :2 (5 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Antinociceptive effect of geranylgeraniol and 6Pterodon pubescens Benth Humberto M Spindola, Leila Servat, Carina Denny, Rodney AF Rodrigues, Marcos N Eberlin, Elaine Cabral, Ilza MO Sousa, Jorge Y Tamashiro, Jo BMC Pharmacology 2010, 10 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors Jan Jakub BMC Pharmacology 2009, 9 :15 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands Christopher N Davis, Stefania Risso Bradley, Hans H Schiffer, Mikael Friberg, Kristian Koch, Bo-Ragnar Tolf, Douglas W Bonhaus, Jelveh Lameh BMC Pharmacology 2009, 9 :14 (2 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway Desheng Lu, Dennis A Carson BMC Pharmacology 2009, 9 :13 (30 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
An efficient drug delivery vehicle for botulism countermeasure Peng Zhang, Radharaman Ray, Bal Ram Singh, Dan Li, Michael Adler, Prabhati Ray BMC Pharmacology 2009, 9 :12 (27 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity Jos BMC Pharmacology 2009, 9 :11 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells Audun O Vik-Mo, Johan Fern BMC Pharmacology 2009, 9 :10 (29 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear Ryusuke Hori, Takayuki Nakagawa, Norio Yamamoto, Kiyomi Hamaguchi, Juichi Ito BMC Neuroscience 2010, 11 :35 (11 [Abstract ] [Provisional PDF ]
Research article
Hygiene inspections on passenger ships in Europe - an overview Varvara A. Mouchtouri, Sandra Westacott, Gordon Nichols, Tobias Riemer, Mel Skipp, Christopher LR Bartlett, Jenny Kremastinou, Christos Hadjichristodoulou, the SHIPSAN Partnership BMC Public Health 2010, 10 :122 (10 [Abstract ] [Provisional PDF ]
Research article
Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity Nicola Marchi, Qingshan Teng, Minh T Nguyen, Linda Franic, Nirav K Desai, Thomas K Masaryk, Peter Rasmussen, Silvia Trasciatti, Damir Janigro BMC Neuroscience 2010, 11 :34 (9 [Abstract ] [Provisional PDF ]
Research article
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence Jay Jin, Saranya Kittanakom, Victoria Wong, Beverly AS Reyes, Elisabeth J Van Bockstaele, Igor Stagljar, Wade Berrettini, Robert Levenson BMC Neuroscience 2010, 11 :33 (9 [Abstract ] [Provisional PDF ]
Research article
Different stress-related phenotypes of BALB/c mice from in-house or vendor: alterations of the sympathetic and HPA axis responsiveness Jakob Olfe, Grazyna Domanska, Christine Schuett, Cornelia Kiank BMC Physiology 2010, 10 :2 (9 [Abstract ] [Provisional PDF ]
Research
Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease Daniel Paris, Nowell J Ganey, Vincent Laporte, Nikunj S Patel, David Beaulieu-Abdelahad, Corbin Bachmeier, Amelia March, Ghania Ait-Ghezala, Michael J Mullan Journal of Neuroinflammation 2010, 7 :17 (8 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines Ansgar M Chromik, Adrien Daigeler, Daniel Bulut, Annegret Flier, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sulberg, Peter R Ritter, Ulrich Mittelkotter, Stephan A Hahn, Waldemar Uhl Journal of Experimental & Clinical Cancer Research 2010, 29 :21 (7 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice Lauren E. Ta, Allan J. Bieber, Susan M. Carlton, Charles L. Loprinzi, Philip A. Low, Anthony J. Windebank Molecular Pain 2010, 6 :15 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats Steve McGaraughty, Katharine L Chu, Richard J Perner, Stanley Didomenico, Michael E Kort, Philip R Kym Molecular Pain 2010, 6 :14 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study Jelena Klawitter, Touraj Shokati, Vanessa Moll, Uwe Christians, Jost Klawitter Breast Cancer Research 2010, 12 :R16 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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