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Volume 13 (2012) - February 2012

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Research article   Open Access Highly Accessed

A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter

Chen Gao, Ming-Ming Pan, Yan-Jun Lei, Li-Qing Tian, Hui-Ying Jiang, Xiao-Li Li, Qi Shi, Chan Tian, Yu-Kang Yuan, Gui-Xiang Fan, Xiao-Ping Dong BMC Molecular Biology 2012, 13:5 (15 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A point mutation of Alanine to Valine at amino acid 338 of the human papillomavirus HPV-2 variant E2 protein enhances its DNA-binding capacity and its ability to activate transcription at the viral early promoter.