BMC Molecular Biology | Vol 12

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Volume 12 (2011) - June 2011

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Liposome-based DNA carriers may induce cellular stress response and change gene expression pattern in transfected cells

Anna Fiszer-Kierzkowska, Natalia Vydra, Aleksandra Wysocka-Wycisk, Zuzana Kronekova, Michał Jarząb, Katarzyna Marta Lisowska, Zdzisław Krawczyk BMC Molecular Biology 2011, 12:27 (10 June 2011)

Abstract | Full text | PDF | PubMed | Editor’s summary

Transfection of cells with liposome-based formulations may not be suitable for functional studies of heat shock promoters as treatment with this class of DNA carriers induces cellular stress and unintended changes in global gene expression.