- Brian Coombes, McMaster University
- Antoine Danchin, AMAbiotics
- Stephen Forsythe, Nottingham Trent University
- Rino Rappuoli, Novartis Vaccines and Diagnostics
- Frank Sargent, University of Dundee
- Jan Maarten van Dijl, University of Groningen
- Irene Wagner-Dobler, Helmholtz Centre for Infection Research
- Philippa Harris, BioMed Central
Listeria monocytogenes modified to express a mutant internalin A, that interacts with murine E-cadherin, are able to efficiently cross the intestinal- but not the blood-brain barrier in mice suggesting different molecular mechanisms for these processes.
Deletion of hfq, an RNA chaperone protein, in Shewanella oneidensis results in reduced growth rate and productivity of aerobic and anaerobic cultures, and compromises the bacterium’s metal-reduction capability potentially due to an increased sensitivity to oxidative stress.
Children with eczema harbour a greater diversity of microbes in the gut than those without, including an increased abundance of bacteria that are typically more common in adults, which may contribute to the perpetuation of the condition.
As laboratory technology increases in sophistication Greg Somerville and Richard Proctor highlight the importance of considering all bacterial culture conditions, such as the flask-to-medium ratio, when designing experiments, to ensure accuracy in the reporting of results.
The Giardia lamblia genome contains many RNA helicases that appear to have a role during both antigenic variation and encystation of the parasite although none have significant homology with the RNA helicase domain of Dicer enzymes.
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BMC Microbiology 2013, 13:77
BMC Microbiology is an open access, peer-reviewed journal that considers articles on analytical and functional studies of prokaryotic and eukaryotic microorganisms, viruses and small parasites, as well as host and therapeutic responses to them and their interaction with the environment.
It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.
BMC series blog
Section Editor’s profile
Brian K. Coombes is currently Associate Professor and Associate Chair of Biochemistry and Biomedical Sciences at McMaster University, Canada. He also holds the Canada Research Chair in Infectious Disease Pathogenesis. Dr Coombes' laboratory investigates the expression and function of bacterial virulence factors in the host, with an emphasis on how these virulence factors interact with the host immune system. His research has uncovered novel virulence factors in bacterial pathogens and has advanced the concept of regulatory evolution as a driver of bacterial pathogenesis."BMC Microbiology is a great way to disseminate research to a wide audience in an open-access forum. We strive to publish the best new research in microbiology and make it available to everyone, thereby accelerating the discovery process and creating a culture of open communication"
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