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1.

2381
Accesses

Research article   Open Access Highly Accessed

Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews

Beverley J Shea, Jeremy M Grimshaw, George A Wells, Maarten Boers, Neil Andersson, Candyce Hamel, Ashley C Porter, Peter Tugwell, David Moher, Lex M Bouter BMC Medical Research Methodology 2007, 7:10 (15 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

2.

2312
Accesses

Commentary   Open Access Highly Accessed

A tutorial on pilot studies: the what, why and how

Lehana Thabane, Jinhui Ma, Rong Chu, Ji Cheng, Afisi Ismaila, Lorena P Rios, Reid Robson, Marroon Thabane, Lora Giangregorio, Charles H Goldsmith BMC Medical Research Methodology 2010, 10:1 (6 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

1597
Accesses

Research article   Open Access Highly Accessed

What about N? A methodological study of sample-size reporting in focus group studies

Benedicte Carlsen, Claire Glenton BMC Medical Research Methodology 2011, 11:26 (11 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

1491
Accesses

Research article   Open Access Highly Accessed

When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt

Benjamin Djulbegovic, Iztok Hozo BMC Medical Research Methodology 2012, 12:85 (22 June 2012)

Abstract | Full text | PDF | PubMed

5.

1416
Accesses

Research article   Open Access Highly Accessed

The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

Penny Whiting, Anne WS Rutjes, Johannes B Reitsma, Patrick MM Bossuyt, Jos Kleijnen BMC Medical Research Methodology 2003, 3:25 (10 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

1380
Accesses

Commentary   Open Access Highly Accessed

The case study approach

Sarah Crowe, Kathrin Cresswell, Ann Robertson, Guro Huby, Anthony Avery, Aziz Sheikh BMC Medical Research Methodology 2011, 11:100 (27 June 2011)

Abstract | Full text | PDF | PubMed

7.

1312
Accesses

Correspondence   Open Access Highly Accessed

What is a pilot or feasibility study? A review of current practice and editorial policy

Mubashir Arain, Michael J Campbell, Cindy L Cooper, Gillian A Lancaster BMC Medical Research Methodology 2010, 10:67 (16 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

1289
Accesses

Correspondence   Open Access Highly Accessed

How to do a grounded theory study: a worked example of a study of dental practices

Alexandra Sbaraini, Stacy M Carter, R Evans, Anthony Blinkhorn BMC Medical Research Methodology 2011, 11:128 (9 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

1230
Accesses

Research article   Open Access Highly Accessed

Effectiveness of Pilates exercise in treating people with chronic low back pain: a systematic review of systematic reviews

Cherie Wells, Gregory S Kolt, Paul Marshall, Bridget Hill, Andrea Bialocerkowski BMC Medical Research Methodology 2013, 13:7 (19 January 2013)

Abstract | Full text | PDF | PubMed

10.

1168
Accesses

Research article   Open Access Highly Accessed

Methods for the thematic synthesis of qualitative research in systematic reviews

James Thomas, Angela Harden BMC Medical Research Methodology 2008, 8:45 (10 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

1082
Accesses

Research article   Open Access Highly Accessed

The stepped wedge trial design: a systematic review

Celia A Brown, Richard J Lilford BMC Medical Research Methodology 2006, 6:54 (8 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

1042
Accesses

Debate   Open Access Highly Accessed

Methods for the synthesis of qualitative research: a critical review

Elaine Barnett-Page, James Thomas BMC Medical Research Methodology 2009, 9:59 (11 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

1011
Accesses

Research article   Open Access Highly Accessed

A systematic review of the content of critical appraisal tools

Persis Katrak, Andrea E Bialocerkowski, Nicola Massy-Westropp, VS Saravana Kumar, Karen A Grimmer BMC Medical Research Methodology 2004, 4:22 (16 September 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Tools for the critical appraisal of research reports often lack information on their development and there is no gold standard for any type of study design.

14.

968
Accesses

Research article   Open Access Highly Accessed

Meta-analysis: Neither quick nor easy

Nancy G Berman, Robert A Parker BMC Medical Research Methodology 2002, 2:10 (9 August 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

968
Accesses

Research article   Open Access Highly Accessed

Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data

Andrew J Vickers BMC Medical Research Methodology 2005, 5:35 (3 November 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

Analysis of simulated data reveals that ANCOVA should be the preferred method for analyzing randomized trials with pre-test and post-test measures and non-normally distributed data, but in cases with extreme skew, Mann-Whitney was preferred.

16.

919
Accesses

Research article   Open Access Highly Accessed

Estimating the mean and variance from the median, range, and the size of a sample

Stela Hozo, Benjamin Djulbegovic, Iztok Hozo BMC Medical Research Methodology 2005, 5:13 (20 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Distribution free estimation of mean and variance for trials where the median, range and size are all that is reported should enable inclusion of more trials in meta-analysis.

17.

845
Accesses

Research article   Open Access Highly Accessed

Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio

Aluísio JD Barros, Vânia N Hirakata BMC Medical Research Methodology 2003, 3:21 (20 October 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

838
Accesses

Research article   Open Access Highly Accessed

Methodology in conducting a systematic review of systematic reviews of healthcare interventions

Valerie Smith, Declan Devane, Cecily M Begley, Mike Clarke BMC Medical Research Methodology 2011, 11:15 (3 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Locating and retrieving relevant literature when conducting a systematic review is challenging but a number of possible solutions are available which may help clinicians appraise published reviews systematically and aid evidence-based clinical decision-making.

19.

799
Accesses

Debate   Open Access Highly Accessed

Qualitative description – the poor cousin of health research?

Mette Neergaard, Frede Olesen, Rikke Andersen, Jens Sondergaard BMC Medical Research Methodology 2009, 9:52 (16 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

727
Accesses

Correspondence   Open Access Highly Accessed

Reducing bias through directed acyclic graphs

Ian Shrier, Robert W Platt BMC Medical Research Methodology 2008, 8:70 (30 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A simple 6-step approach to applying direct acyclic graphs in biomedical research may aid researchers to more accurately identify and adjust for multiple confounding effects and reduce the degree of bias better than traditional methods.

21.

726
Accesses

Commentary   Open Access Highly Accessed

Sample size calculations for cluster randomised controlled trials with a fixed number of clusters

Karla Hemming, Alan J Girling, Alice J Sitch, Jennifer Marsh, Richard J Lilford BMC Medical Research Methodology 2011, 11:102 (30 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

22.

704
Accesses

Research article   Open Access Highly Accessed

The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

David Moher, Kenneth F Schulz, Douglas G Altman BMC Medical Research Methodology 2001, 1:2 (20 April 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

656
Accesses

Debate   Open Access Highly Accessed

Conducting a meta-ethnography of qualitative literature: Lessons learnt

Salla Atkins, Simon Lewin, Helen Smith, Mark Engel, Atle Fretheim, Jimmy Volmink BMC Medical Research Methodology 2008, 8:21 (16 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Although meta-ethnography offers a useful methodology for the synthesis of qualitative research, its application to the study of adherence to tuberculosis treatment highlights a number of methodological and epistemological challenges which must still be addressed.

24.

595
Accesses

Research article   Open Access Highly Accessed

The Hawthorne Effect: a randomised, controlled trial

Rob McCarney, James Warner, Steve Iliffe, Robbert van Haselen, Mark Griffin, Peter Fisher BMC Medical Research Methodology 2007, 7:30 (3 July 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

557
Accesses

Debate   Open Access

Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity

Marshall Godwin, Lucia Ruhland, Ian Casson, Susan MacDonald, Dianne Delva, Richard Birtwhistle, Miu Lam, Rachelle Seguin BMC Medical Research Methodology 2003, 3:28 (22 December 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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