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26.

244
Accesses

Research article   Open Access

Discriminating lymphomas and reactive lymphadenopathy in lymph node biopsies by gene expression profiling

To Ha Loi, Anna Campain, Adam Bryant, Tim J Molloy, Mark Lutherborrow, Jennifer Turner, Yee Yang, David DF Ma BMC Medical Genomics 2011, 4:27 (31 March 2011)

Abstract | Full text | PDF | PubMed

27.

244
Accesses

Research   Open Access

Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers

Xiaoping Liu, Rui Liu, Xing-Ming Zhao, Luonan Chen BMC Medical Genomics 2013, 6(Suppl 2):S8 (7 May 2013)

Abstract | Full text | PDF | ePUB

28.

241
Accesses

Research article   Open Access Highly Accessed

DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Nahid Turan, Mohamed F Ghalwash, Sunita Katari, Christos Coutifaris, Zoran Obradovic, Carmen Sapienza BMC Medical Genomics 2012, 5:10 (12 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Profiling of inter-individual DNA methylation differences in neonates has identified 23 genes that account for 70-87% of variance in birth weight, whilst traditional gene expression profiling identified a far smaller proportion.

29.

239
Accesses

Research article   Open Access Highly Accessed

Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

Bertalan Mesko, Szilard Poliska1, Andrea Szegedi, Zoltan Szekanecz, Karoly Palatka, Maria Papp, Laszlo Nagy BMC Medical Genomics 2010, 3:15 (5 May 2010)

Abstract | Full text | PDF | PubMed

30.

238
Accesses

Research article   Open Access Highly Accessed

A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

Andrey Loboda, Michael Nebozhyn, Rich Klinghoffer, Jason Frazier, Michael Chastain, William Arthur, Brian Roberts, Theresa Zhang, Melissa Chenard, Brian Haines, Jannik Andersen, Kumiko Nagashima, Cloud Paweletz, Bethany Lynch, Igor Feldman, Hongyue Dai, Pearl Huang, James Watters BMC Medical Genomics 2010, 3:26 (30 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

238
Accesses

Review   Open Access Highly Accessed

Completion of the swine genome will simplify the production of swine as a large animal biomedical model

Eric M Walters, Eckhard Wolf, Jeffery J Whyte, Jiude Mao, Simone Renner, Hiroshi Nagashima, Eiji Kobayashi, Jianguo Zhao, Kevin D Wells, John K Critser, Lela K Riley, Randall S Prather BMC Medical Genomics 2012, 5:55 (15 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Eric M Walters and colleagues review the pig as a large animal biomedical model and how the publication of the swine genome sequence will further advance its utility for understanding human disease, transgenesis and xenotransplantation.

32.

237
Accesses

Research article   Open Access Highly Accessed

A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy

Robin M Hallett, Gregory Pond, John A Hassell BMC Medical Genomics 2012, 5:16 (11 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Two new gene expression signatures can predict how breast cancer tumors will respond to two of the common kinds of chemotherapy, highlighting the potential of target-based gene expression indices to predict patient response to drug therapy.

33.

229
Accesses

Correspondence   Open Access Highly Accessed

The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies

Catherine A McCarty, Rex L Chisholm, Christopher G Chute, Iftikhar J Kullo, Gail P Jarvik, Eric B Larson, Rongling Li, Daniel R Masys, Marylyn D Ritchie, Dan M Roden, Jeffery P Struewing, Wendy A Wolf, the eMERGE Team BMC Medical Genomics 2011, 4:13 (26 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

227
Accesses

Research article   Open Access Highly Accessed

Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Nicola VL Serão, Kristin R Delfino, Bruce R Southey, Jonathan E Beever, Sandra L Rodriguez-Zas BMC Medical Genomics 2011, 4:49 (7 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

35.

220
Accesses

Research article   Open Access Highly Accessed

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju, Jaime Matta BMC Medical Genomics 2008, 1:13 (28 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

221
Accesses

Research article   Open Access

Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern european family population

Yi Zhang, Jack W Kent, Adam Lee, Diana Cerjak, Omar Ali, Robert Diasio, Michael Olivier, John Blangero, Melanie A Carless, Ahmed H Kissebah BMC Medical Genomics 2013, 6:9 (19 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

37.

220
Accesses

Debate   Open Access Highly Accessed

"Who owns your poop?": insights regarding the intersection of human microbiome research and the ELSI aspects of biobanking and related studies

Alice K Hawkins, Kieran C O'Doherty BMC Medical Genomics 2011, 4:72 (7 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

218
Accesses

Research article   Open Access Highly Accessed

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

Serban Nacu, Wenlin Yuan, Zhengyan Kan, Deepali Bhatt, Celina Rivers, Jeremy Stinson, Brock A Peters, Zora Modrusan, Kenneth Jung, Somasekar Seshagiri, Thomas D Wu BMC Medical Genomics 2011, 4:11 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

218
Accesses

Research article   Open Access Highly Accessed

Impact of RNA degradation on gene expression profiling

Lennart Opitz, Gabriela Salinas-Riester, Marian Grade, Klaus Jung, Peter Jo, Georg Emons, B Michael Ghadimi, Tim Beißbarth, Jochen Gaedcke BMC Medical Genomics 2010, 3:36 (9 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

214
Accesses

Research article   Open Access

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

Kristina M Hettne, André Boorsma, Dorien A M van Dartel, Jelle J Goeman, Esther de Jong, Aldert H Piersma, Rob H Stierum, Jos C Kleinjans, Jan A Kors BMC Medical Genomics 2013, 6:2 (29 January 2013)

Abstract | Full text | PDF | PubMed

41.

212
Accesses

Research article   Open Access Highly Accessed

A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease

Nalini Raghavachari, Jennifer Barb, Yanqin Yang, Poching Liu, Kimberly Woodhouse, Daniel Levy, Christopher J O‘Donnell, Peter J Munson, Gregory J Kato BMC Medical Genomics 2012, 5:28 (29 June 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

42.

211
Accesses

Research article   Open Access

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

Andreas Schlicker, Garry Beran, Christine M Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides, Tim French, Lodewyk FA Wessels BMC Medical Genomics 2012, 5:66 (31 December 2012)

Abstract | Full text | PDF | PubMed

43.

204
Accesses

Research article   Open Access

Pivotal role of the muscle-contraction pathway in cryptorchidism and evidence for genomic connections with cardiomyopathy pathways in RASopathies

Carlo V Cannistraci, Jernej Ogorevc, Minja Zorc, Timothy Ravasi, Peter Dovc, Tanja Kunej BMC Medical Genomics 2013, 6:5 (14 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

44.

202
Accesses

Debate   Open Access Highly Accessed

The role of disease characteristics in the ethical debate on personal genome testing

Eline M Bunnik, Maartje HN Schermer, A Cecile JW Janssens BMC Medical Genomics 2012, 5:4 (19 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

202
Accesses

Research article   Open Access Highly Accessed

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

Daria Grafodatskaya, Barian HY Chung, Darci T Butcher, Andrei L Turinsky, Sarah J Goodman, Sana Choufani, Yi-An Chen, Youliang Lou, Chunhua Zhao, Rageen Rajendram, Fatima E Abidi, Cindy Skinner, James Stavropoulos, Carolyn A Bondy, Jill Hamilton, Shoshana Wodak, Stephen W Scherer, Charles E Schwartz, Rosanna Weksberg BMC Medical Genomics 2013, 6:1 (28 January 2013)

Abstract | Full text | PDF | PubMed

46.

202
Accesses

Research article   Open Access

Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

Emma N Bermingham, Shalome A Bassett, Wayne Young, Nicole C Roy, Warren C McNabb, Janine M Cooney, Di T Brewster, William A Laing, Matthew PG Barnett BMC Medical Genomics 2013, 6:7 (5 March 2013)

Abstract | Full text | PDF | PubMed

47.

201
Accesses

Research article   Open Access Highly Accessed

Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer

Xiaohong Li, Ryan Gill, Nigel GF Cooper, Jae Yoo, Susmita Datta BMC Medical Genomics 2011, 4:44 (19 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

200
Accesses

Research article   Open Access

Genome-wide associations of signaling pathways in glioblastoma multiforme

Stefan Wuchty, Alexei Vazquez, Serdar Bozdag, Peter O Bauer BMC Medical Genomics 2013, 6:11 (28 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

49.

199
Accesses

Research article   Open Access Highly Accessed

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Andrey Loboda, Walter K Kraft, Bernard Fine, Jeffrey Joseph, Michael Nebozhyn, Chunsheng Zhang, Yudong He, Xia Yang, Christopher Wright, Mark Morris, Ira Chalikonda, Mark Ferguson, Valur Emilsson, Amy Leonardson, John Lamb, Hongyue Dai, Eric Schadt, Howard E Greenberg, Pek Lum BMC Medical Genomics 2009, 2:7 (9 February 2009)

Abstract | Full text | PDF | PubMed

50.

197
Accesses

Research   Open Access

Analysis of small-sample clinical genomics studies using multi-parameter shrinkage: application to high-throughput RNA interference screening

Mark A van de Wiel, Renée X de Menezes, Ellen Siebring-van Olst, Victor W van Beusechem BMC Medical Genomics 2013, 6(Suppl 2):S1 (7 May 2013)

Abstract | Full text | PDF | ePUB

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