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	1. 1634 Accesses	Research article Global analysis of DNA methylation in early-stage liver fibrosis Yoko Komatsu, Tsuyoshi Waku, Naoya Iwasaki, Wakana Ono, Chie Yamaguchi, Junn Yanagisawa BMC Medical Genomics 2012, 5:5 (27 January 2012) Abstract \| Full text \| PDF \| PubMed
	2. 996 Accesses	Research article The effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated Shubin W Shahab, Lilya V Matyunina, Christopher G Hill, Lijuan Wang, Roman Mezencev, L Walker, John F McDonald BMC Medical Genomics 2012, 5:33 (1 August 2012) Abstract \| Full text \| PDF \| PubMed
	3. 850 Accesses	Research article Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease Andrew J Levine, Jeremy A Miller, Paul Shapshak, Benjamin Gelman, Elyse J Singer, Charles H Hinkin, Deborah Commins, Susan Morgello, Igor Grant, Steve Horvath BMC Medical Genomics 2013, 6:4 (13 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Re-analysis of existing transcriptomic datasets from the brains of patients with HIV-associated neurocognitive impairment, using a systems biology approach, corroborates their results but also identifies possible co-expression networks linked to neurocognitive impairment in HIV and Alzheimer’s disease.
	4. 842 Accesses	Review Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases Douglas B Kell BMC Medical Genomics 2009, 2:2 (8 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Douglas Kell reviews the role of iron-catalysed free radicals in disease, which underpin the behavior of many physiological and pathological processes, and considers the need for better understanding using an integrative, systems-level approach.
	5. 810 Accesses	Technical advance Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li, Peipei Li, Yuying Yuan, Xiaoyu Pan, Yihan Li, Lifu Liu, Huifei Chen, Zhaoling Xuan, Shengpei Chen, Chunlei Zhang, Hongyun Zhang, Zhongming Tian, Zhengyu Zhang, Hui Jiang, Lijian Zhao, Weimou Zheng, Songgang Li, Yingrui Li, Jun Wang, Jian Wang, Xiuqing Zhang et al. BMC Medical Genomics 2012, 5:57 (1 December 2012) Abstract \| Full text \| PDF \| PubMed
	6. 781 Accesses	Research article PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers Roy RL Bastien, Álvaro Rodríguez-Lescure, Mark TW Ebbert, Aleix Prat, Blanca Munárriz, Leslie Rowe, Patricia Miller, Manuel Ruiz-Borrego, Daniel Anderson, Bradley Lyons, Isabel Álvarez, Tracy Dowell, David Wall, Miguel Seguí, Lee Barley, Kenneth M Boucher, Emilio Alba, Lisa Pappas, Carole A Davis, Ignacio Aranda, Christiane Fauron, Inge J Stijleman, José Palacios, Antonio Antón, Eva Carrasco, Rosalía Caballero, Matthew J Ellis, Torsten O Nielsen, Charles M Perou, Mark Astill, Philip S Bernard, Miguel Martín et al. BMC Medical Genomics 2012, 5:44 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	7. 752 Accesses	Research article Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C Daria Grafodatskaya, Barian HY Chung, Darci T Butcher, Andrei L Turinsky, Sarah J Goodman, Sana Choufani, Yi-An Chen, Youliang Lou, Chunhua Zhao, Rageen Rajendram, Fatima E Abidi, Cindy Skinner, James Stavropoulos, Carolyn A Bondy, Jill Hamilton, Shoshana Wodak, Stephen W Scherer, Charles E Schwartz, Rosanna Weksberg BMC Medical Genomics 2013, 6:1 (28 January 2013) Abstract \| Full text \| PDF \| PubMed
	8. 561 Accesses	Database The Roche Cancer Genome Database 2.0 Jan Küntzer, Daniela Maisel, Hans-Peter Lenhof, Stefan Klostermann, Helmut Burtscher BMC Medical Genomics 2011, 4:43 (17 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The enlarged Roche Cancer Genome Database integrates information from a number of human mutation databases and mutation data curated from the literature, with an improved interface and search functionality over the earlier version.
	9. 505 Accesses	Research article Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization Zhi-Zhou Shi, Yue-Ming Zhang, Li Shang, Jia-Jie Hao, Tong-Tong Zhang, Bo-Shi Wang, Jian-Wei Liang, Xi Chen, Ying Zhang, Gui-Qi Wang, Ming-Rong Wang, Yu Zhang BMC Medical Genomics 2012, 5:52 (16 November 2012) Abstract \| Full text \| PDF \| PubMed
	10. 470 Accesses	Research article Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs Perry Evans, William Dampier, Lyle Ungar, Aydin Tozeren BMC Medical Genomics 2009, 2:27 (18 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	11. 462 Accesses	Research article Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity Martin Kerick, Melanie Isau, Bernd Timmermann, Holger Sültmann, Ralf Herwig, Sylvia Krobitsch, Georg Schaefer, Irmgard Verdorfer, Georg Bartsch, Helmut Klocker, Hans Lehrach, Michal R Schweiger BMC Medical Genomics 2011, 4:68 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	12. 448 Accesses	Research article Pivotal role of the muscle-contraction pathway in cryptorchidism and evidence for genomic connections with cardiomyopathy pathways in RASopathies Carlo V Cannistraci, Jernej Ogorevc, Minja Zorc, Timothy Ravasi, Peter Dovc, Tanja Kunej BMC Medical Genomics 2013, 6:5 (14 February 2013) Abstract \| Provisional PDF \| PubMed
	13. 386 Accesses	Proceedings Potential roles of microRNAs in regulating long intergenic noncoding RNAs Liran Juan, Guohua Wang, Milan Radovich, Bryan P Schneider, Susan E Clare, Yadong Wang, Yunlong Liu BMC Medical Genomics 2013, 6(Suppl 1):S7 (23 January 2013) Abstract \| Full text \| PDF \| PubMed
	14. 367 Accesses	Research article Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data Kristina M Hettne, André Boorsma, Dorien A M van Dartel, Jelle J Goeman, Esther de Jong, Aldert H Piersma, Rob H Stierum, Jos C Kleinjans, Jan A Kors BMC Medical Genomics 2013, 6:2 (29 January 2013) Abstract \| Full text \| PDF \| PubMed
	15. 348 Accesses	Research article Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines Andreas Schlicker, Garry Beran, Christine M Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides, Tim French, Lodewyk FA Wessels BMC Medical Genomics 2012, 5:66 (31 December 2012) Abstract \| Full text \| PDF \| PubMed
	16. 347 Accesses	Proceedings A novel method for the normalization of microRNA RT-PCR data Rehman Qureshi, Ahmet Sacan BMC Medical Genomics 2013, 6(Suppl 1):S14 (23 January 2013) Abstract \| Full text \| PDF \| PubMed
	17. 320 Accesses	Research article MicroRNA profiling of diverse endothelial cell types Matthew N McCall, Oliver A Kent, Jianshi Yu, Karen Fox-Talbot, Ari L Zaiman, Marc K Halushka BMC Medical Genomics 2011, 4:78 (2 November 2011) Abstract \| Full text \| PDF \| PubMed
	18. 319 Accesses	Research article Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles Julia Tchou, Andrew V Kossenkov, Lisa Chang, Celine Satija, Meenhard Herlyn, Louise C Showe, Ellen Puré BMC Medical Genomics 2012, 5:39 (6 September 2012) Abstract \| Full text \| PDF \| PubMed
	19. 293 Accesses	Research article A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease Nalini Raghavachari, Jennifer Barb, Yanqin Yang, Poching Liu, Kimberly Woodhouse, Daniel Levy, Christopher J O‘Donnell, Peter J Munson, Gregory J Kato BMC Medical Genomics 2012, 5:28 (29 June 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	20. 292 Accesses	Review Completion of the swine genome will simplify the production of swine as a large animal biomedical model Eric M Walters, Eckhard Wolf, Jeffery J Whyte, Jiude Mao, Simone Renner, Hiroshi Nagashima, Eiji Kobayashi, Jianguo Zhao, Kevin D Wells, John K Critser, Lela K Riley, Randall S Prather BMC Medical Genomics 2012, 5:55 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eric M Walters and colleagues review the pig as a large animal biomedical model and how the publication of the swine genome sequence will further advance its utility for understanding human disease, transgenesis and xenotransplantation.
	21. 273 Accesses	Research article A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors Andrey Loboda, Michael Nebozhyn, Rich Klinghoffer, Jason Frazier, Michael Chastain, William Arthur, Brian Roberts, Theresa Zhang, Melissa Chenard, Brian Haines, Jannik Andersen, Kumiko Nagashima, Cloud Paweletz, Bethany Lynch, Igor Feldman, Hongyue Dai, Pearl Huang, James Watters BMC Medical Genomics 2010, 3:26 (30 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22. 256 Accesses	Research article Impact of RNA degradation on gene expression profiling Lennart Opitz, Gabriela Salinas-Riester, Marian Grade, Klaus Jung, Peter Jo, Georg Emons, B Michael Ghadimi, Tim Beißbarth, Jochen Gaedcke BMC Medical Genomics 2010, 3:36 (9 August 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 256 Accesses	Research article DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease? Nahid Turan, Mohamed F Ghalwash, Sunita Katari, Christos Coutifaris, Zoran Obradovic, Carmen Sapienza BMC Medical Genomics 2012, 5:10 (12 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Profiling of inter-individual DNA methylation differences in neonates has identified 23 genes that account for 70-87% of variance in birth weight, whilst traditional gene expression profiling identified a far smaller proportion.
	24. 250 Accesses	Research Recursive SVM biomarker selection for early detection of breast cancer in peripheral blood Fan Zhang, Howard L Kaufman, Youping Deng, Renee Drabier BMC Medical Genomics 2013, 6(Suppl 1):S4 (23 January 2013) Abstract \| Full text \| PDF \| PubMed
	25. 243 Accesses	Research article Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice Wilma T Steegenga, Nicole JW de Wit, Mark V Boekschoten, Noortje IJssennagger, Carolien Lute, Shohreh Keshtkar, Mechteld M Bromhaar, Ellen Kampman, Lisette C de Groot, Michael Muller BMC Medical Genomics 2012, 5:38 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The small intestine and colons of aging mice do not show marked changes in expression of genes involved in metabolic processes, however immune response and inflammation gene expression increases and aging-induced global hypomethylation is also present.