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1.

1363
Accesses

Research article   Open Access Highly Accessed

Evaluation of the bacterial diversity of Pressure ulcers using bTEFAP pyrosequencing

Drake M Smith, David E Snow, Eric Rees, Ann M Zischkau, J Delton Hanson, Randall D Wolcott, Yan Sun, Jennifer White, Shashi Kumar, Scot E Dowd BMC Medical Genomics 2010, 3:41 (21 September 2010)

Abstract | Full text | PDF | PubMed | f1000

2.

930
Accesses

Review   Open Access Highly Accessed

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Douglas B Kell BMC Medical Genomics 2009, 2:2 (8 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Douglas Kell reviews the role of iron-catalysed free radicals in disease, which underpin the behavior of many physiological and pathological processes, and considers the need for better understanding using an integrative, systems-level approach.

3.

760
Accesses

Research article   Open Access Highly Accessed

PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

Roy RL Bastien, Álvaro Rodríguez-Lescure, Mark TW Ebbert, Aleix Prat, Blanca Munárriz, Leslie Rowe, Patricia Miller, Manuel Ruiz-Borrego, Daniel Anderson, Bradley Lyons, Isabel Álvarez, Tracy Dowell, David Wall, Miguel Seguí, Lee Barley, Kenneth M Boucher, Emilio Alba, Lisa Pappas, Carole A Davis, Ignacio Aranda, Christiane Fauron, Inge J Stijleman, José Palacios, Antonio Antón, Eva Carrasco, Rosalía Caballero, Matthew J Ellis, Torsten O Nielsen, Charles M Perou, Mark Astill, Philip S Bernard, Miguel Martín et al. BMC Medical Genomics 2012, 5:44 (4 October 2012)

Abstract | Full text | PDF | PubMed

4.

734
Accesses

Research article   Open Access

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle

Eric B Meltzer, William T Barry, Thomas A D'Amico, Robert D Davis, Shu S Lin, Mark W Onaitis, Lake D Morrison, Thomas A Sporn, Mark P Steele, Paul W Noble BMC Medical Genomics 2011, 4:70 (5 October 2011)

Abstract | Full text | PDF | PubMed

5.

694
Accesses

Technical advance   Open Access Highly Accessed

Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies

Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li, Peipei Li, Yuying Yuan, Xiaoyu Pan, Yihan Li, Lifu Liu, Huifei Chen, Zhaoling Xuan, Shengpei Chen, Chunlei Zhang, Hongyun Zhang, Zhongming Tian, Zhengyu Zhang, Hui Jiang, Lijian Zhao, Weimou Zheng, Songgang Li, Yingrui Li, Jun Wang, Jian Wang, Xiuqing Zhang et al. BMC Medical Genomics 2012, 5:57 (1 December 2012)

Abstract | Full text | PDF | PubMed

6.

572
Accesses

Research article   Open Access

Identification of potential synthetic lethal genes to p53 using a computational biology approach

Xiaosheng Wang, Richard Simon BMC Medical Genomics 2013, 6:30 (11 September 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

562
Accesses

Research article   Open Access

Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma

Qu Zhang, Jun Zhang, Hong Jin, Sitong Sheng BMC Medical Genomics 2013, 6:28 (4 September 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

548
Accesses

Research article   Open Access

Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea

Siriporn Chatsuriyawong, David Gozal, Leila Kheirandish-Gozal, Rakesh Bhattacharjee, Ahamed A Khalyfa, Yang Wang, Wasana Sukhumsirichart, Abdelnaby Khalyfa BMC Medical Genomics 2013, 6:29 (6 September 2013)

Abstract | Full text | PDF | PubMed

9.

364
Accesses

Research article   Open Access

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

Domenica Ronchetti, Laura Mosca, Giovanna Cutrona, Giacomo Tuana, Massimo Gentile, Sonia Fabris, Luca Agnelli, Gabriella Ciceri, Serena Matis, Carlotta Massucco, Monica Colombo, Daniele Reverberi, Anna Recchia, Sabrina Bossio, Massimo Negrini, Pierfrancesco Tassone, Fortunato Morabito, Manlio Ferrarini, Antonino Neri BMC Medical Genomics 2013, 6:27 (3 September 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

333
Accesses

Software   Open Access

Genotyping of human neutrophil antigens (HNA) from whole genome sequencing data

Hsueh-Ting Chu, Han Lin, Theresa Tsun-Hui Tsao, Chun-Fan Chang, William WL Hsiao, Tze-Jung Yeh, Ching-Mao Chang, Yen-Wenn Liu, Tse-Yi Wang, Ko-Chun Yang, Tsung-Jui Chen, Jen-Chih Chen, Kuang-Chi Chen, Cheng-Yan Kao BMC Medical Genomics 2013, 6:31 (12 September 2013)

Abstract | Provisional PDF | PubMed

11.

326
Accesses

Research   Open Access

Potential roles of microRNAs in regulating long intergenic noncoding RNAs

Liran Juan, Guohua Wang, Milan Radovich, Bryan P Schneider, Susan E Clare, Yadong Wang, Yunlong Liu BMC Medical Genomics 2013, 6(Suppl 1):S7 (23 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

316
Accesses

Research   Open Access

Altering physiological networks using drugs: steps towards personalized physiology

Adam D Grossman, Mitchell J Cohen, Geoffrey T Manley, Atul J Butte BMC Medical Genomics 2013, 6(Suppl 2):S7 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

13.

315
Accesses

Research article   Open Access Highly Accessed

Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes

Wen-Wen Xu, Miao-Jun Han, Dai Chen, Ling Chen, Yan Guo, Andrew Willden, Di-Qiu Liu, Hua-Tang Zhang BMC Medical Genomics 2013, 6:15 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Important regulatory genes associated with cell cycle functions and the actin cytoskeleton are potentially implicated with HIV-1 resistance in CD4+ T cells, elucidated using a co-expression network analysis.

14.

274
Accesses

Research article   Open Access Highly Accessed

MicroRNA profiling of diverse endothelial cell types

Matthew N McCall, Oliver A Kent, Jianshi Yu, Karen Fox-Talbot, Ari L Zaiman, Marc K Halushka BMC Medical Genomics 2011, 4:78 (2 November 2011)

Abstract | Full text | PDF | PubMed

15.

274
Accesses

Research article   Open Access Highly Accessed

Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease

Andrew J Levine, Jeremy A Miller, Paul Shapshak, Benjamin Gelman, Elyse J Singer, Charles H Hinkin, Deborah Commins, Susan Morgello, Igor Grant, Steve Horvath BMC Medical Genomics 2013, 6:4 (13 February 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Re-analysis of existing transcriptomic datasets from the brains of patients with HIV-associated neurocognitive impairment, using a systems biology approach, corroborates their results but also identifies possible co-expression networks linked to neurocognitive impairment in HIV and Alzheimer’s disease.

16.

271
Accesses

Research article   Open Access Highly Accessed

Cancer patient perceptions on the ethical and legal issues related to biobanking

Zubin Master, Jaime O Claudio, Christen Rachul, Jean CY Wang, Mark D Minden, Timothy Caulfield BMC Medical Genomics 2013, 6:8 (8 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In a survey of perceptions of leukemia patients towards biobanking research ethics, majorities favoured one-time consent and retaining the right to withdrawal, and almost all favoured being informed of incidental findings relevant to their health.

17.

263
Accesses

Research article   Open Access Highly Accessed

Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity

Martin Kerick, Melanie Isau, Bernd Timmermann, Holger Sültmann, Ralf Herwig, Sylvia Krobitsch, Georg Schaefer, Irmgard Verdorfer, Georg Bartsch, Helmut Klocker, Hans Lehrach, Michal R Schweiger BMC Medical Genomics 2011, 4:68 (29 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

260
Accesses

Research article   Open Access Highly Accessed

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Andrey Loboda, Walter K Kraft, Bernard Fine, Jeffrey Joseph, Michael Nebozhyn, Chunsheng Zhang, Yudong He, Xia Yang, Christopher Wright, Mark Morris, Ira Chalikonda, Mark Ferguson, Valur Emilsson, Amy Leonardson, John Lamb, Hongyue Dai, Eric Schadt, Howard E Greenberg, Pek Lum BMC Medical Genomics 2009, 2:7 (9 February 2009)

Abstract | Full text | PDF | PubMed

19.

247
Accesses

Technical advance   Open Access Highly Accessed

Expression profiling with RNA from formalin-fixed, paraffin-embedded material

Andrea Oberli, Vlad Popovici, Mauro Delorenzi, Anna Baltzer, Janine Antonov, Sybille Matthey, Stefan Aebi, Hans Altermatt, Rolf Jaggi BMC Medical Genomics 2008, 1:9 (19 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

247
Accesses

Software   Open Access Highly Accessed

Genotator: A disease-agnostic tool for genetic annotation of disease

Dennis P Wall, Rimma Pivovarov, Mark Tong, Jae-Yoon Jung, Vincent A Fusaro, Todd F DeLuca, Peter J Tonellato BMC Medical Genomics 2010, 3:50 (29 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

241
Accesses

Research article   Open Access Highly Accessed

Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities

Reinhold J Medina, Christina L O'Neill, Mark Sweeney, Jasenka Guduric-Fuchs, Tom A Gardiner, David A Simpson, Alan W Stitt BMC Medical Genomics 2010, 3:18 (13 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | f1000

22.

241
Accesses

Research article   Open Access Highly Accessed

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

Christopher G Bell, Andrew E Teschendorff, Vardhman K Rakyan, Alexander P Maxwell, Stephan Beck, David A Savage BMC Medical Genomics 2010, 3:33 (5 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

229
Accesses

Research article   Open Access Highly Accessed

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju, Jaime Matta BMC Medical Genomics 2008, 1:13 (28 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

225
Accesses

Research article   Open Access Highly Accessed

Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Chung, Pearlly Yan, Tim HM Huang, Sun Kim, Kenneth P Nephew BMC Medical Genomics 2009, 2:34 (8 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

223
Accesses

Research article   Open Access

A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation

Yi Zhang, Jack W Kent, Michael Olivier, Omar Ali, Diana Cerjak, Ulrich Broeckel, Reham M Abdou, Thomas D Dyer, Anthony Comuzzie, Joanne E Curran, Melanie A Carless, David L Rainwater, Harald H H Göring, John Blangero, Ahmed H Kissebah BMC Medical Genomics 2013, 6:14 (29 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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