- Francisco Azuaje, CRP-Santé
- Struan Grant, Children's Hospital of Philadelphia
- Patrick Tan, Graduate Medical School Singapore
- Pearlly Yan, The Ohio State University
- Tim Sands , BioMed Central
Integrative analysis of publicly available TCGA datasets including mutations, copy number alterations, gene expression and methylation using elastic-net identifies genes that are predictive for stage and aggressiveness of colorectal cancer tumors.
A co-expression network approach on existing pre-eclampsia genomic datasets in combination with genetic algorithms prioritizes genes known to be associated with the disease but also new pathogenesis candidates.
Histone modifications but not a candidate transcription factor are associated with steatohepatitis in alcoholic liver disease, and regions enriched for histone modifications contain genes known to be involved in the disease and new candidates.
News from the web
- 17 December 2013
- Pertinent and Non-pertinent Genomic Findings
- 10 December 2013
- How emerging targeted mutation technologies could change the way we study human genetics
BMC Medical Genomics is an open access, peer-reviewed journal that considers articles on all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
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Following posts in the UK, Australia, Iceland and Germany, Struan Grant has been the Associate Director of the Center for Applied Genomics at the Children's Hospital of Philadelphia since 2006. His current work focuses on metabolic disease, with a specific focus on pediatrics. Utilizing high-throughput genotyping technology, his goals include isolating genes involved in obesity and bone strength. Both of these phenotypes are known to be strongly determined by genetic factors and distillation of this component should be easier to determine in children, where the relatively short period of their lifetime limits the impact of environmental exposure.
BMC series blog
- 03 December 2013
- Highlights of the BMC-series: November 2013
- 20 November 2013
- APHA: For science. For action. For health.
- 18 November 2013
- BMC Geriatrics at the 2013 BGS Autumn Scientific Meeting
Volume 6 Suppl 3 (11 November 2013)
Selected articles from the IEEE International Conference on Bioinformatics and Biomedicine 2012: Medical Genomics
Philadelphia, PA, USA. 4-7 October 2012