New anthropometry-based age- and sex-specific reference values for urinary 24-hour creatinine excretion based on the adult Swiss population
BMC Medicine 2015, 13:40 (27 February 2015)
A new prediction equation based on sex, age and body mass index provides reliable estimates of 24-hour urinary creatinine excretion in European adults, suggesting this equation could be used to overcome limitations with current reference values.
Diagnosis and management of hyponatraemia: AGREEing the guidelines
BMC Medicine 2015, 13:31 (13 February 2015)
Alexander Maxwell comments on a systematic review showing that clinical practice guidelines on hyponatremia vary in methodological quality, and highlights that greater consistency of future guidelines would help clinicians manage patients optimally.
Renal function during long-term lithium treatment: a cross-sectional and longitudinal study
BMC Medicine 2015, 13:12 (21 January 2015)
Duration of lithium therapy is associated with reduced kidney function regardless of subsequent discontinuation once kidneys are already damaged, suggesting that kidney risk should be weighed against lithium’s beneficial effects for mood disorders.
Diagnosis and treatment of hyponatremia: a systematic review of clinical practice guidelines and consensus statements
van der Veer,
BMC Medicine 2014, 12:231 (11 December 2014)
Evidence from a systematic review suggests clinical practice guidelines on diagnosing and treating hyponatremia offer inconsistent recommendations and are of varying methodological quality, indicating the need for greater consistency.
Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: a cross-sectional study
BMC Medicine 2014, 12:125 (29 July 2014)
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HIV-infected adults who have been using antiretroviral therapy for over two years have a higher incidence of hypertension compared with adults without HIV, indicating that screening measures should be targeted towards these patients.
suPAR and Team Nephrology
BMC Medicine 2014, 12:82 (20 May 2014)
New research suggests urinary suPAR can distinguish focal segmental glomerulosclerosis (FSGS) from other glomerulopathies; Howard Trachtman discusses the relevance of this work, highlighting the need for more evaluation of novel biomarkers.
Urinary soluble urokinase receptor levels are elevated and pathogenic in patients with primary focal segmental glomerulosclerosis
BMC Medicine 2014, 12:81 (20 May 2014)
High levels of plasma soluble urokinase receptor (suPAR) in urine are specifically and functionally linked to severity of focal segmental glomerulosclerosis (FSGS), suggesting suPAR could contribute to the pathogenesis of end-stage renal disease.
Duration of lithium treatment is a risk factor for reduced glomerular function: a cross-sectional study
BMC Medicine 2013, 11:33 (11 February 2013)
In patients with affective disorders, the duration of lithium treatment and advanced age are risk factors for glomerular failure, suggesting that kidney toxicity should be weighed against the protective effects of lithium in these patients.