CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so
BMC Medicine 2015, 13:154 (7 July 2015)
Specific types of monocytes ingest opsonized malaria erythrocytes and stimulate inflammation, indicating that these cells have a special role in activating the immune system against P. falciparum infection, which should be considered in vaccine design.
Asymptomatic transmission and the resurgence of Bordetella pertussis
BMC Medicine 2015, 13:146 (24 June 2015)
Resurgence of whooping cough (Bordetella pertussis) in the US and UK may be caused by asymptomatic transmission, according to a modeling and phylodynamic analysis, so vaccination policies should be adapted to ensure successful eradication.
EGFR-directed antibodies increase the risk of severe infection in cancer patients
BMC Medicine 2015, 13:37 (20 February 2015)
Barbara Burtness and Mehmet Altan comment on research showing an increased risk of severe infection in cancer patients on EGFR-directed antibody therapy, highlighting that dose modification strategies could be developed to reduce infection risk.
The hunt for protective correlates of immunity to Plasmodium falciparum malaria
BMC Medicine 2014, 12:134 (8 August 2014)
This article is part of a collection on
Ann Moormann and Ann Stewart comment on a study showing that opsonic phagocytosis of malaria parasites contributes to protective immunity, and describe how understanding the mechanisms of protection will inform malaria vaccine design.
Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria
BMC Medicine 2014, 12:108 (1 July 2014)
This article is part of collection:
Medicine for Global Health...
Opsonic phagocytosis in Plasmodium falciparum malaria parasites contributes to protective immunity in infected individuals, suggesting that phagocytosis could be measured to assess vaccine response and population immunity.
Accuracy of epidemiological inferences based on publicly available information: retrospective comparative analysis of line lists of human cases infected with influenza A(H7N9) in China
BMC Medicine 2014, 12:88 (28 May 2014)
Analyses of publicly-available data on influenza A (H7N9) virus infection provide reliable estimations of transmissibility but limited information on disease severity, suggesting these data could be useful to analyze the spread of infection.
B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components
BMC Medicine 2013, 11:217 (9 October 2013)
Peter Eichacker and colleagues describe the contribution of toxins and non-toxins to cardiovascular dysfunction and shock following B. anthracis infection, and discuss how better understanding of the mechanisms could help improve anthrax management.
A low-cost method to assess the epidemiological importance of individuals in controlling infectious disease outbreaks
BMC Medicine 2013, 11:35 (12 February 2013)
A low-cost ranking method for modeling the spread of influenza in schools identifies subpopulations at higher risk of early infection than randomly selected communities, which could be effective for predicting and preventing epidemics.
How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?
Van den Bruel,
BMC Medicine 2013, 11:10 (15 January 2013)
Clinical prediction rules to recognize infections in children do not show perfect diagnostic accuracy in high and low prevalence ambulatory care settings, suggesting that additional laboratory tests should be used to increase certainty.