Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
BMC Medicine 2013, 11:228 (23 October 2013)
Exposing female rats to dichlorodiphenyltrichloroethane (DDT) promotes obesity and associated epigenetic changes three generations later, suggesting that some cases of obesity may be partly due to environmentally induced transgenerational inheritance.
Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era
BMC Medicine 2013, 11:168 (19 July 2013)
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Early detection of lung cancer is important so patients can be treated as soon as possible; Avrum Spira and colleagues review genetic and genomic biomarkers in development for early diagnosis, and discuss how they could reduce lung cancer deaths.
Fat dads must not be blamed for their children's health problems
BMC Medicine 2013, 11:30 (6 February 2013)
Gudrun Moore and Philip Stainer comment on a recent study showing that fathers’ obesity is related to gene methylation changes in offspring, but highlight that the results should not be over-emphasized and future studies should consider whole genomes.
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
BMC Medicine 2013, 11:29 (6 February 2013)
Obesity in fathers is associated with a decrease in methylation of the insulin-like growth factor 2 gene in their newborns, suggesting that paternal obesity may disrupt normal imprinting in germ cells and affect the health of their offspring.
Perinatal nicotine exposure induces asthma in second generation offspring
BMC Medicine 2012, 10:129 (30 October 2012)
Smoking during pregnancy induces asthma in offspring, and the effects are permanently transmitted to subsequent generations via epigenetic changes in germ cells, providing a breakthrough in studying transgenerational effects of toxins.