B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components
BMC Medicine 2013, 11:217 (9 October 2013)
Peter Eichacker and colleagues describe the contribution of toxins and non-toxins to cardiovascular dysfunction and shock following B. anthracis infection, and discuss how better understanding of the mechanisms could help improve anthrax management.
Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy
BMC Medicine 2012, 10:134 (7 November 2012)
Catalase protects against effects of anthrax infection in mice by rescuing toxin-induced cardiac contractile dysfunction and intracellular calcium anomalies, via regulation of mitochondrial function and autophagy, providing therapeutic promise in the management of toxin induced cardiovascular complications.