A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
BMC Medicine 2014, 12:117 (10 July 2014)
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Medicine for Global Health...
In an analysis of data from nine phase 2 trials of the RTS,S malaria vaccine, anti-circumsporozoite protein antibody titres and transmission intensity are linked to malaria protection, explaining the variations seen in vaccine efficacy.
Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines
BMC Medicine 2013, 11:232 (30 October 2013)
The first generation malaria vaccine is likely to be only partially efficacious; in light of this, Freya Fowkes and colleagues discuss methodological considerations for the development of clinical trials for a second generation malaria vaccine.
Impact of a population-based HPV vaccination program on cervical abnormalities: a data linkage study
BMC Medicine 2013, 11:227 (22 October 2013)
In Australia, a population-based human papillomavirus (HPV) vaccination program in schools reduces cervical abnormalities in vaccinated women, indicating that the program is effective in reducing the burden of HPV-related diseases.
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data
BMC Medicine 2013, 11:184 (21 August 2013)
Variation in RTS,S malaria vaccine efficacy between individuals can be attributed to differences in peripheral blood monocyte-to-lymphocyte ratio measured before vaccination, indicating that individuals most receptive to RTS,S can be targeted.