Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines
BMC Medicine 2013, 11:232 (30 October 2013)
The first generation malaria vaccine is likely to be only partially efficacious; in light of this, Freya Fowkes and colleagues discuss methodological considerations for the development of clinical trials for a second generation malaria vaccine.
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data
BMC Medicine 2013, 11:184 (21 August 2013)
Variation in RTS,S malaria vaccine efficacy between individuals can be attributed to differences in peripheral blood monocyte-to-lymphocyte ratio measured before vaccination, indicating that individuals most receptive to RTS,S can be targeted.