BMC Medicine | Tags | #Depression

1.

So depression is an inflammatory disease, but where does the inflammation come from?

Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes BMC Medicine 2013, 11:200 (12 September 2013)

This article is part of a collection on Current Controversies in...

Abstract | Full text | PDF | Editor’s summary

Depression is associated with a low-grade inflammatory response; Michael Berk and colleagues discuss the sources of inflammation, oxidative and nitrosative stress in depression and emphasize that these factors can be treated or prevented.

2.

Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, BMC Medicine 2013, 11:192 (30 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.

3.

Tobacco smoking and depression: time to move on to a new research paradigm in medicine?

Peter de Jonge, Elisabeth Bos BMC Medicine 2013, 11:138 (24 May 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data.

4.

Depression, antidepressant medications, and risk of Clostridium difficile infection

Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.

5.

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, Daniel F Hermens BMC Medicine 2013, 11:79 (22 March 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

There is a need for specific therapies for major depression; Ian Hickie and colleagues recommend that sleep-wake cycles and circadian systems should be targets for mood disorders to provide a personalized approach to patient treatment.

6.

Hypersomnia and depressive symptoms: methodological and clinical aspects

Yves Dauvilliers, Régis Lopez, Maurice Ohayon, Sophie Bayard BMC Medicine 2013, 11:78 (21 March 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Yves Dauvilliers and colleagues review the quality and breadth of studies linking hypersomnia and depression, and highlight that interventional studies are needed to ascertain if management of sleep disorders can improve mood disorders and vice versa.

7.

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne O'Neil, Christopher G Davey, Livia Sanna, Michael Maes BMC Medicine 2013, 11:74 (18 March 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.

8.

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

Nilay Hepgul, Annamaria Cattaneo, Patricia A Zunszain, Carmine M Pariante BMC Medicine 2013, 11:28 (5 February 2013)

This article is part of a collection on Clinical biomarkers

Abstract | Full text | PDF | PubMed | Editor’s summary

Carmine Pariante and colleagues review the altered pattern of peripheral gene expression in patients with major depressive disorder, and comment on the clinical applicability of potential biomarkers to measure these reversible changes in patients.

9.

Data-driven subtypes of major depressive disorder: a systematic review

Hanna M van Loo, Peter de Jonge, Jan-Willem Romeijn, Ronald C Kessler, Robert A Schoevers BMC Medicine 2012, 10:156 (4 December 2012)

A systematic review and meta-analysis of studies using latent variable models shows that evidence for data-driven symptomatic subtypes in major depressive disorder is limited, indicating future studies should consider choice of statistical approach.

10.

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki, Brian Leonard BMC Medicine 2012, 10:66 (29 June 2012)

Michael Maes and colleagues review the protective role of inflammation in sickness behavior, in contrast to negative symptoms associated with depression, and suggest these shared immuno-inflammatory pathways can explain the phenomenological similarities between the two conditions.

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	1.	Opinion So depression is an inflammatory disease, but where does the inflammation come from? Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes BMC Medicine 2013, 11:200 (12 September 2013) This article is part of a collection on Current Controversies in... Abstract \| Full text \| PDF \| Editor’s summary Depression is associated with a low-grade inflammatory response; Michael Berk and colleagues discuss the sources of inflammation, oxidative and nitrosative stress in depression and emphasize that these factors can be treated or prevented.
	2.	Research article Alcohol intake, wine consumption and the development of depression: the PREDIMED study Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, BMC Medicine 2013, 11:192 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.
	3.	Commentary Tobacco smoking and depression: time to move on to a new research paradigm in medicine? Peter de Jonge, Elisabeth Bos BMC Medicine 2013, 11:138 (24 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data.
	4.	Research article *Depression, antidepressant medications, and risk of Clostridium difficile* infection** Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
	5.	Opinion Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, Daniel F Hermens BMC Medicine 2013, 11:79 (22 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is a need for specific therapies for major depression; Ian Hickie and colleagues recommend that sleep-wake cycles and circadian systems should be targets for mood disorders to provide a personalized approach to patient treatment.
	6.	Review Hypersomnia and depressive symptoms: methodological and clinical aspects Yves Dauvilliers, Régis Lopez, Maurice Ohayon, Sophie Bayard BMC Medicine 2013, 11:78 (21 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yves Dauvilliers and colleagues review the quality and breadth of studies linking hypersomnia and depression, and highlight that interventional studies are needed to ascertain if management of sleep disorders can improve mood disorders and vice versa.
	7.	Opinion Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne O'Neil, Christopher G Davey, Livia Sanna, Michael Maes BMC Medicine 2013, 11:74 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.
	8.	Review Depression pathogenesis and treatment: what can we learn from blood mRNA expression? Nilay Hepgul, Annamaria Cattaneo, Patricia A Zunszain, Carmine M Pariante BMC Medicine 2013, 11:28 (5 February 2013) This article is part of a collection on Clinical biomarkers Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carmine Pariante and colleagues review the altered pattern of peripheral gene expression in patients with major depressive disorder, and comment on the clinical applicability of potential biomarkers to measure these reversible changes in patients.
	9.	Research article Data-driven subtypes of major depressive disorder: a systematic review Hanna M van Loo, Peter de Jonge, Jan-Willem Romeijn, Ronald C Kessler, Robert A Schoevers BMC Medicine 2012, 10:156 (4 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A systematic review and meta-analysis of studies using latent variable models shows that evidence for data-driven symptomatic subtypes in major depressive disorder is limited, indicating future studies should consider choice of statistical approach.
	10.	Review Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki, Brian Leonard BMC Medicine 2012, 10:66 (29 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Michael Maes and colleagues review the protective role of inflammation in sickness behavior, in contrast to negative symptoms associated with depression, and suggest these shared immuno-inflammatory pathways can explain the phenomenological similarities between the two conditions.