BMC Medicine | Most Viewed

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Medicine

Advertisement

Articles

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
	1. 6009 Accesses	Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
	2. 5979 Accesses	Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
	3. 4578 Accesses	Opinion Spectrum of gluten-related disorders: consensus on new nomenclature and classification Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.
	4. 2464 Accesses	Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
	5. 2423 Accesses	Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
	6. 2339 Accesses	Research article How do autoimmune diseases cluster in families? A systematic review and meta-analysis Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga, Juan-Manuel Anaya BMC Medicine 2013, 11:73 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows autoimmune diseases, particularly autoimmune thyroid disease and systemic lupus erythematosus, aggregate in families, indicating that shared genetic factors may be responsible.
	7. 2186 Accesses	Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
	8. 2040 Accesses	Research article Mental illness related disparities in diabetes prevalence, quality of care and outcomes: a population-based longitudinal study Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery, David B Preen BMC Medicine 2011, 9:118 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Disparities in diabetes prevalence and the quality and outcome of diabetic care of those with mental illness and those without in Australia highlights the need for better, more integrated care for this population.
	9. 1907 Accesses	Research article Cross-national epidemiology of DSM-IV major depressive episode Evelyn Bromet, Laura Andrade, Irving Hwang, Nancy A Sampson, Jordi Alonso, Giovanni de Girolamo, Ron de Graaf, Koen Demyttenaere, Chiyi Hu, Noboru Iwata, Aimee N Karam, Jagdish Kaur, Stanislav Kostyuchenko, Jean-Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Mora, Mark Browne, Jose Posada-Villa, Maria Viana, David R Williams, Ronald C Kessler BMC Medicine 2011, 9:90 (26 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Major depression is a significant public health problem around the globe which affects women twice as commonly as men and is most strongly correlated with being separated, divorced or widowed.
	10. 1885 Accesses	Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
	11. 1829 Accesses	Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
	12. 1803 Accesses	Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
	13. 1773 Accesses	Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
	14. 1742 Accesses	Research article Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates IC McManus, A Keeling, E Paice BMC Medicine 2004, 2:29 (18 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Doctors' stress and career satisfaction are partly determined by their different learning styles and can be predicted by studying their personality and habits at medical school.
	15. 1684 Accesses	Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
	16. 1649 Accesses	Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
	17. 1605 Accesses	Review Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.
	18. 1548 Accesses	Research article Anatomy of open access publishing: a study of longitudinal development and internal structure Mikael Laakso, Bo-Christer Björk BMC Medicine 2012, 10:124 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The landscape of scientific publishing has changed during the last decade due to steady growth of open access (OA) journals, as the volume of scientific articles published between 2000-2011 in full immediate OA journals has grown rapidly in relative annual share of published journal articles.
	19. 1536 Accesses	Research article Body mass index and incident coronary heart disease in women: a population-based prospective study Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F Wright, Jane Green, Gillian Reeves, Valerie Beral, the Million Women Study Collaborators BMC Medicine 2013, 11:87 (2 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Coronary heart disease increases with BMI in over 1 million women and this risk is not confounded by age, smoking, physical activity, alcohol consumption and status, suggesting population changes in BMI will reduce the burden of disease.
	20. 1516 Accesses	Research article Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsæter BMC Medicine 2013, 11:42 (19 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caffeine intake from various sources during pregnancy is associated with increased risk of the baby being small for gestational age and decreased birth weight, which may have implications for the recommended consumption of caffeine.
	21. 1417 Accesses	Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
	22. 1374 Accesses	Review Novel therapeutic agents in clinical development for Systemic Lupus Erythematosus Natasha Jordan, Pamela M K Lutalo, David P D'Cruz BMC Medicine 2013, 11:120 (3 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials.
	23. 1368 Accesses	Research article Characteristics, changes and influence of body composition during a 4486km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
	24. 1355 Accesses	Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
	25. 1332 Accesses	Research article Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.
	26. 1336 Accesses	Review The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment.
	27. 1326 Accesses	Debate Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders.
	28. 1311 Accesses	Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
	29. 1247 Accesses	Opinion Tackling overweight and obesity: does the public health message match the science? Katherine Hafekost, David Lawrence, Francis Mitrou, Therese A O'Sullivan, Stephen R Zubrick BMC Medicine 2013, 11:41 (18 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many weight-loss interventions based on a simple model of energy balance fail to achieve long-term results; Stephen R Zubrick and colleagues recommend that multiple factors affecting energy regulation should be considered in order to tackle obesity.
	30. 1200 Accesses	Research article Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten BMC Medicine 2013, 11:112 (26 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary When compared with universal rotavirus (RV) vaccination, targeted vaccination of high-risk children is highly cost-effective in the Netherlands, suggesting that targeted strategies should be used to reduce RV hospitalizations in Europe.
	31. 1167 Accesses	Review Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.
	32. 1146 Accesses	Review Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.
	33. 1127 Accesses	Research article Effects of breastfeeding on body composition and maturational tempo in the rat Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg BMC Medicine 2013, 11:114 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaning from lactation at an early age leads to faster development and leaner, longer bodies in comparison to late-weaned rats, and these effects are transmitted through generations as early-weaned progeny reach sexual maturation at an earlier age.
	34. 1123 Accesses	Debate Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders.
	35. 1118 Accesses	Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.
	36. 1096 Accesses	Review Novel aspects of Sjögren’s syndrome in 2012 Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld BMC Medicine 2013, 11:93 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Angela Tincani and colleagues review the latest developments in Sjogren's Syndrome research and therapies, and highlight a possible link between Vitamin D levels and development of the disease.
	37. 1061 Accesses	Correspondence CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials Kenneth F Schulz, Douglas G Altman, David Moher, the CONSORT Group BMC Medicine 2010, 8:18 (24 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The latest version of the CONSORT statement, used worldwide to help improve the reporting of randomized controlled trials, updates the reporting guidelines based on new methodological evidence and amassed experience.
	38. 1046 Accesses	Minireview Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis Niels Høiby BMC Medicine 2011, 9:32 (4 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hoiby reviews recent advances in treatment of chronic Pseudomonas aeruginosa lung infection due to biofilm formation in cystic fibrosis patients, with a focus on inhalation therapy targeted towards prophylaxis and chronic suppressive therapy.
	39. 1028 Accesses	Research article Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar, Theodore Mazzone BMC Medicine 2012, 10:3 (10 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The safe reversal of Type 1 diabetes is possible with Stem Cell Educator therapy which uses stem cells from cord blood to re-educate a diabetic's own T cells, restarts pancreatic function, and reduces the need for insulin.
	40. 1005 Accesses	Research article Apps for asthma self-management: a systematic assessment of content and tools Kit Huckvale, Mate Car, Cecily Morrison, Josip Car BMC Medicine 2012, 10:144 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic assessment of apps for asthma self-management finds that none combine reliable information with appropriate supportive tools, thus physicians considering recommending these should apply caution as some apps may be unsafe.
	41. 1007 Accesses	Research article Open access versus subscription journals: a comparison of scientific impact Bo-Christer Björk, David Solomon BMC Medicine 2012, 10:73 (17 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology \| Editor’s summary The scientific impact of articles published in open access (OA) and subscription journals are similar when journal discipline, location of publisher and age of publication are compared, which is particularly true in medicine and health, where OA journals founded in the last 10 years receive on average as many citations as subscription journals launched during the same time.
	42. 986 Accesses	Research article The Alvarado score for predicting acute appendicitis: a systematic review Robert Ohle, Fran O'Reilly, Kirsty K O'Brien, Tom Fahey, Borislav D Dimitrov BMC Medicine 2011, 9:139 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Alvarado score is a ten-point clinical scoring system used to stratify patients with suspected appendicitis, and a systematic review shows that in all patient groups, the score is useful in ruling out appendicitis at a cut point of 5 five or below.
	43. 977 Accesses	Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
	44. 948 Accesses	Minireview Understanding the benefit of metformin use in cancer treatment Ryan JO Dowling, Pamela J Goodwin, Vuk Stambolic BMC Medicine 2011, 9:33 (6 April 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Metformin has long been known to combat diabetes, but its mechanisms of action are now known to also provide potent anti-tumor action, reviewed here by Stambolic and colleagues.
	45. 949 Accesses	Editorial The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5.
	46. 945 Accesses	Debate Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.
	47. 935 Accesses	Commentary Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS) Paul N Goldwater, Karl A Bettelheim BMC Medicine 2012, 10:12 (2 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In light of the verotoxigenic E. coli (VTEC) European epidemic in 2011, Goldwater and Bettelheim comment on the complex pathogenesis of these strains and recommend a multi-targeted approach to current and future treatment strategies.
	48. 938 Accesses	Opinion Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne ONeil, Christopher G Davey, Livia Sanna, Michael Maes BMC Medicine 2013, 11:74 (18 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.
	49. 921 Accesses	Minireview Advances in understanding and treating ADHD Kevin M Antshel, Teresa M Hargrave, Mihai Simonescu, Prashant Kaul, Kaitlin Hendricks, Stephen V Faraone BMC Medicine 2011, 9:72 (10 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Antshel and colleagues review the advances over the past decade in the understanding and treatment of Attention Deficit Hyperactivity Disorder (ADHD), which comprise both tailored stimulant formulations and cognitive behavioral interventions.
	50. 920 Accesses	Commentary Patient advocacy and DSM-5 Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.