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1.

80866
Accesses

Research article   Open Access Highly Accessed

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.

2.

73128
Accesses

Opinion   Open Access Highly Accessed

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.

3.

62303
Accesses

Research article   Open Access Highly Accessed

Acetylcysteine for prevention of contrast-induced nephropathy after intravascular angiography: A systematic review and meta-analysis

Sean M Bagshaw, William A Ghali BMC Medicine 2004, 2:38 (22 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A systematic review shows that the efficacy of acetylcysteine for the prevention of contrast-induced nephropathy on patients undergoing angiography remains unclear and highlights the need for a large, multi-center trial.

4.

58668
Accesses

Research article   Open Access Highly Accessed

Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates

IC McManus, A Keeling, E Paice BMC Medicine 2004, 2:29 (18 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

Doctors' stress and career satisfaction are partly determined by their different learning styles and can be predicted by studying their personality and habits at medical school.

5.

56809
Accesses

Research article   Open Access Highly Accessed

Prediction of falls using a risk assessment tool in the acute care setting

Alexandra Papaioannou, William Parkinson, Richard Cook, Nicole Ferko, Esther Coker, Jonathan D Adachi BMC Medicine 2004, 2:1 (21 January 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A study of elderly patients in two hospitals in Ontario has led to modification of a method used to predict the risk of falling in British hospitals. As a result, a predictive risk score for each patient can now be used in Canadian hospitals.

6.

54429
Accesses

Research article   Open Access Highly Accessed

Cross-national epidemiology of DSM-IV major depressive episode

Evelyn Bromet, Laura Andrade, Irving Hwang, Nancy A Sampson, Jordi Alonso, Giovanni de Girolamo, Ron de Graaf, Koen Demyttenaere, Chiyi Hu, Noboru Iwata, Aimee N Karam, Jagdish Kaur, Stanislav Kostyuchenko, Jean-Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Mora, Mark Browne, Jose Posada-Villa, Maria Viana, David R Williams, Ronald C Kessler BMC Medicine 2011, 9:90 (26 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Major depression is a significant public health problem around the globe which affects women twice as commonly as men and is most strongly correlated with being separated, divorced or widowed.

7.

50837
Accesses

Research article   Open Access Highly Accessed

Sudden Infant Death Syndrome and prenatal maternal smoking: rising attributed risk in the Back to Sleep era

Mark E Anderson, Daniel C Johnson, Holly A Batal BMC Medicine 2005, 3:4 (11 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

After a campaign to encourage the supine sleeping position for infants, the attributed risk associating maternal smoking and sudden infant death syndrome increased.

8.

48824
Accesses

Research article   Open Access Highly Accessed

Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001

Liam Smeeth, Claire Cook, Professor Fombonne, Lisa Heavey, Laura C Rodrigues, Peter G Smith, Andrew J Hall BMC Medicine 2004, 2:39 (9 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Data from the UK show that the rate of pervasive developmental disorders has risen substantially in the last decade. Some, but not all, of this increase is likely to be a result of improved diagnosis.

9.

48430
Accesses

Research article   Open Access Highly Accessed

Mental illness related disparities in diabetes prevalence, quality of care and outcomes: a population-based longitudinal study

Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery, David B Preen BMC Medicine 2011, 9:118 (1 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Disparities in diabetes prevalence and the quality and outcome of diabetic care of those with mental illness and those without in Australia highlights the need for better, more integrated care for this population.

10.

46906
Accesses

Research article   Open Access Highly Accessed

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

Nicola Marchi, Kerri L Hallene, Kelly M Kight, Luca Cucullo, Gabriel Moddel, William Bingaman, Gabriele Dini, Annamaria Vezzani, Damir Janigro BMC Medicine 2004, 2:37 (9 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The overexpression of multiple drug resistance protein (MDR1) in cells from the brains of epileptics who are refractory to drug treatment may result in lower penetrance of drugs into active sites and also be associated with higher neuroglial survival and reduced apoptosis.

11.

46670
Accesses

Research article   Open Access Highly Accessed

Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

Maria M Medveczky, Tracy A Sherwood, Thomas W Klein, Herman Friedman, Peter G Medveczky BMC Medicine 2004, 2:34 (15 September 2004)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In cell cultures, the active ingredient of cannabis, delta-9-tetrahydrocannibol (THC), can inhibit the replication and activation of several gamma herpesviruses, including two that are associated with human tumors.

12.

46425
Accesses

Research article   Open Access Highly Accessed

An international comparative study of blood pressure in populations of European vs. African descent

Richard S Cooper, Katharina Wolf-Maier, Amy Luke, Adebowale Adeyemo, José R Banegas, Terrence Forrester, Simona Giampaoli, Michel Joffres, Mika Kastarinen, Paola Primatesta, Birgitta Stegmayr, Michael Thamm BMC Medicine 2005, 3:2 (5 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

International data suggests that high rates of hypertension in African Americans might have more to do with lifestyle and socio-economic background than with racial origin, contradicting previous studies.

13.

46358
Accesses

Research article   Open Access Highly Accessed

Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar, Theodore Mazzone BMC Medicine 2012, 10:3 (10 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The safe reversal of Type 1 diabetes is possible with Stem Cell Educator therapy which uses stem cells from cord blood to re-educate a diabetic's own T cells, restarts pancreatic function, and reduces the need for insulin.

14.

45194
Accesses

Research article   Open Access Highly Accessed

Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management

David R Fleisher, Blake Gornowicz, Kathleen Adams, Richard Burch, Edward J Feldman BMC Medicine 2005, 3:20 (21 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Cyclical Vomiting Syndrome is a little studied but disabling condition, occurring in adults as well as children; appreciation of comorbidities such as migraine, anxiety and inter-episodic dyspeptic nausea may improve diagnosis.

15.

44382
Accesses

Research article   Open Access Highly Accessed

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.

16.

41574
Accesses

Research article   Open Access Highly Accessed

What do evidence-based secondary journals tell us about the publication of clinically important articles in primary healthcare journals?

Kathleen McKibbon, Nancy L Wilczynski, Robert Haynes BMC Medicine 2004, 2:33 (6 September 2004)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

An assessment of 60,000 articles from 170 healthcare journals finds that the majority of clinically useful articles in each discipline are published in a small subset of journals.

17.

41282
Accesses

Commentary   Open Access Highly Accessed

Blood pressure demographics: nature or nurture ... ... genes or environment?

Joseph Tomson, Gregory YH Lip BMC Medicine 2005, 3:3 (7 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

40868
Accesses

Research article   Open Access Highly Accessed

Neoadjuvant or adjuvant therapy for resectable esophageal cancer: a systematic review and meta-analysis

Richard A Malthaner, Rebecca KS Wong, R Bryan Rumble, Lisa Zuraw, Members of the Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care. BMC Medicine 2004, 2:35 (24 September 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A systematic review on the use of adjuvant and neoadjuvant therapy on esophageal cancer shows that surgery alone is the optimal treatment for those patients for whom a complete resection is possible.

19.

40484
Accesses

Research article   Open Access Highly Accessed

What does my patient's coronary artery calcium score mean? Combining information from the coronary artery calcium score with information from conventional risk factors to estimate coronary heart disease risk

Mark J Pletcher, Jeffrey A Tice, Michael Pignone, Charles McCulloch, Tracy Q Callister, Warren S Browner BMC Medicine 2004, 2:31 (24 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The addition of standard risk factors to the coronary artery calcium score can affect the clinical assessment of coronary heart disease risks.

20.

39706
Accesses

Research article   Open Access Highly Accessed

Khat use as risk factor for psychotic disorders: A cross-sectional and case-control study in Somalia

Michael Odenwald, Frank Neuner, Maggie Schauer, Thomas Elbert, Claudia Catani, Birke Lingenfelder, Harald Hinkel, Heinz Häfner, Brigitte Rockstroh BMC Medicine 2005, 3:5 (12 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Specific patterns of khat consumption such as early onset and excessive use are associated with an increased risk of psychotic disorders. Any legal restrictions to khat use should take these into consideration in cultures where consumption is widespread.

21.

38915
Accesses

Minireview   Open Access Highly Accessed

Understanding the benefit of metformin use in cancer treatment

Ryan JO Dowling, Pamela J Goodwin, Vuk Stambolic BMC Medicine 2011, 9:33 (6 April 2011)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Metformin has long been known to combat diabetes, but its mechanisms of action are now known to also provide potent anti-tumor action, reviewed here by Stambolic and colleagues.

22.

38577
Accesses

Research article   Open Access Highly Accessed

A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology

John McGrath, Sukanta Saha, Joy Welham, Ossama El Saadi, Clare MacCauley, David Chant BMC Medicine 2004, 2:13 (28 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A systematic review shows that reported rates of schizophrenia are more widely distributed in men than in women. Studies of urban and migrant populations also show wide variability.

23.

36805
Accesses

Research article   Open Access Highly Accessed

Recurrent cardiac events in patients with idiopathic ventricular fibrillation, excluding patients with the Brugada syndrome

Jean Champagne, Peter Geelen, François Philippon, Pedro Brugada BMC Medicine 2005, 3:1 (1 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

After exclusion of those suffering from Brugada syndrome, patients with idiopathic ventricular fibrillation still show a high recurrence of potentially fatal ventricular arrhythmias. Treatment with implantable cardioverter defibrillator prevents sudden cardiac death but can result in inappropriate shocks during follow-up.

24.

34763
Accesses

Research article   Open Access Highly Accessed

The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393]

Heart Protection Study Collaborative Group BMC Medicine 2005, 3:6 (16 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A large trial of simvastatin treatment on patients with vascular disease or diabetes has shown that a reduction in cholesterol is not associated with adverse effects on non-vascular mortality or cancer incidence.

25.

33987
Accesses

Research article   Open Access Highly Accessed

Graduates of different UK medical schools show substantial differences in performance on MRCP(UK) Part 1, Part 2 and PACES examinations

IC McManus, Andrew T Elder, Andre de Champlain, Jane E Dacre, Jennifer Mollon, Liliana Chis BMC Medicine 2008, 6:5 (14 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

Graduates from different UK medical schools vary in their performance on the postgraduate MRCP and PACES examinations; therefore the authors call for the introduction of a national medical licensing examination.

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