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	1. 2503 Accesses	Opinion Spectrum of gluten-related disorders: consensus on new nomenclature and classification Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.
	2. 2241 Accesses	Research article Lifestyle interventions for overweight and obese pregnant women to improve pregnancy outcome: systematic review and meta-analysis Eugene Oteng-Ntim, Rajesh Varma, Helen Croker, Lucilla Poston, Pat Doyle BMC Medicine 2012, 10:47 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis suggests that lifestyle intervention during pregnancy can reduce the risk of gestational diabetes and weight gain in obese women, highlighting the importance of intervention at this crucial time.
	3. 1783 Accesses	Research article Mental illness related disparities in diabetes prevalence, quality of care and outcomes: a population-based longitudinal study Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery, David B Preen BMC Medicine 2011, 9:118 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Disparities in diabetes prevalence and the quality and outcome of diabetic care of those with mental illness and those without in Australia highlights the need for better, more integrated care for this population.
	4. 1672 Accesses	Minireview Understanding the benefit of metformin use in cancer treatment Ryan JO Dowling, Pamela J Goodwin, Vuk Stambolic BMC Medicine 2011, 9:33 (6 April 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Metformin has long been known to combat diabetes, but its mechanisms of action are now known to also provide potent anti-tumor action, reviewed here by Stambolic and colleagues.
	5. 1651 Accesses	Research article Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar, Theodore Mazzone BMC Medicine 2012, 10:3 (10 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The safe reversal of Type 1 diabetes is possible with Stem Cell Educator therapy which uses stem cells from cord blood to re-educate a diabetic's own T cells, restarts pancreatic function, and reduces the need for insulin.
	6. 1645 Accesses	Research article Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores Nobutake Yamamichi, Satoshi Mochizuki, Itsuko Asada-Hirayama, Rie Mikami-Matsuda, Takeshi Shimamoto, Maki Konno-Shimizu, Yu Takahashi, Chihiro Takeuchi, Keiko Niimi, Satoshi Ono, Shinya Kodashima, Chihiro Minatsuki, Mitsuhiro Fujishiro, Toru Mitsushima, Kazuhiko Koike BMC Medicine 2012, 10:45 (3 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A large scale study finds that lifestyle factors such as sleep and diet correlate with gastroesophageal reflux disease (GERD) symptoms, which cannot be fully relieved by drugs, so changing daily activities could reduce the severity of GERD.
	7. 1597 Accesses	Minireview New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids Michel DE Lorgeril, Patricia Salen BMC Medicine 2012, 10:50 (21 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary de Lorgeril and Salen review recent findings on the effects of different types of dietary fats on cardiovascular disease and cancer, concluding that low intake of omega-6 reduces disease risk due to its link with breast cancer.
	8. 1509 Accesses	Research article Cross-national epidemiology of DSM-IV major depressive episode Evelyn Bromet, Laura Andrade, Irving Hwang, Nancy A Sampson, Jordi Alonso, Giovanni de Girolamo, Ron de Graaf, Koen Demyttenaere, Chiyi Hu, Noboru Iwata, Aimee N Karam, Jagdish Kaur, Stanislav Kostyuchenko, Jean-Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Mora, Mark Browne, Jose Posada-Villa, Maria Viana, David R Williams, Ronald C Kessler BMC Medicine 2011, 9:90 (26 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Major depression is a significant public health problem around the globe which affects women twice as commonly as men and is most strongly correlated with being separated, divorced or widowed.
	9. 1310 Accesses	Commentary A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer Silvia von der Heyde, Tim Beissbarth BMC Medicine 2012, 10:43 (1 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A new method published in BMC Genomics identifies gene expression changes downstream of EGFR; von der Heyde and Beissbarth comment on the importance of this method to identify changes associated with cetuximab resistance in head and neck cancer.
	10. 1297 Accesses	Commentary The regulation of mobile health applications Amy J Barton BMC Medicine 2012, 10:46 (8 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Medical applications on mobile phones are increasingly being used, and some are associated with safety concerns; Amy Barton comments on the regulation of mobile heath applications by the FDA, and discusses implications for the future.
	11. 1293 Accesses	Commentary Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold? Jasvinder A Singh BMC Medicine 2012, 10:44 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jasvinder Singh discusses emerging novel therapies for osteoarthritis (OA), and comments on clinical implications of a recent study in BMC Musculoskeletal Disorders, where injected stem cells had reparative effects on damaged cartilage in an animal model of OA.
	12. 1182 Accesses	Technical advance Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery Ioannis Prassas, Caitlin C Chrystoja, Shalini Makawita, Eleftherios P Diamandis BMC Medicine 2012, 10:39 (19 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A novel bioinformatics strategy that mines publicly available databases identifies tissue-specific proteins that are candidates for cancer serum biomarkers, overcoming the limitations of current biomarkers, which lack tissue specificity.
	13. 1154 Accesses	Research article Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.
	14. 1138 Accesses	Review Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.
	15. 1078 Accesses	Review Clinical trials for stem cell therapies Alan Trounson, Rahul G Thakar, Geoff Lomax, Don Gibbons BMC Medicine 2011, 9:52 (10 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Trounson and colleagues review recent developments and future prospects of clinical trials for stem cell therapies, highlighting usage of mesenchymal and neural stem cells, and reporting on the start of trials involving lines derived from pluripotent cells.
	16. 1010 Accesses	Opinion The role of nutrition in integrated programs to control neglected tropical diseases Andrew Hall, Yaobi Zhang, Chad MacArthur, Shawn Baker BMC Medicine 2012, 10:41 (25 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Neglected tropical diseases (NTDs) are prevalent in malnourished populations and are exacerbated by undernutrition; Andrew Hall and colleagues propose that the efficacy of NTD control programs can be increased by including nutritional interventions.
	17. 964 Accesses	Research article Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility Guixiang Ji, Aihua Gu, Yan Long, Yong Zhou, Cong Huang, Xinru Wang BMC Medicine 2012, 10:49 (17 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Single nucleotide polymorphisms in mismatch repair (MMR) genes are associated with sperm deficiency, and patients with MMR variants and normal sperm levels have increased sperm DNA damage, revealing new genetic risk factors for male infertility.
	18. 865 Accesses	Research article Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function Yingmei Zhang, Sara A Babcock, Nan Hu, Jacalyn R Maris, Haichang Wang, Jun Ren BMC Medicine 2012, 10:40 (23 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mitochondrial aldehyde dehydrogenase (ALDH2) protects against diabetes-induced cardiovascular disease (CVD) by regulating mitochondrial function and GSK3β signaling, providing therapeutic promise in the management of diabetic complications.
	19. 862 Accesses	Correspondence CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials Kenneth F Schulz, Douglas G Altman, David Moher, the CONSORT Group BMC Medicine 2010, 8:18 (24 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The latest version of the CONSORT statement, used worldwide to help improve the reporting of randomized controlled trials, updates the reporting guidelines based on new methodological evidence and amassed experience.
	20. 779 Accesses	Minireview Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis Niels Høiby BMC Medicine 2011, 9:32 (4 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hoiby reviews recent advances in treatment of chronic Pseudomonas aeruginosa lung infection due to biofilm formation in cystic fibrosis patients, with a focus on inhalation therapy targeted towards prophylaxis and chronic suppressive therapy.
	21. 777 Accesses	Review Novel regulatory therapies for prevention of Graft-versus-host disease Joseph Leventhal, Yiming Huang, Hong Xu, Idona Goode, Suzanne T Ildstad BMC Medicine 2012, 10:48 (15 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Complications arising during allogeneic hematopoietic stem cell transplantation include onset of graft-versus-host disease (GVHD); here Joseph Leventhal et al. review the promising advances made with cell-based therapies which can potentially prevent GVHD and promote engraftment.
	22. 773 Accesses	Research article Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis Atle Fretheim, Jan Odgaard-Jensen, Odd Brørs, Steinar Madsen, Inger Njølstad, Ole F Norheim, Arne Svilaas, Ivar S Kristiansen, Hanne Thürmer, Signe Flottorp BMC Medicine 2012, 10:33 (5 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the primary prevention of cardiovascular disease (CVD), there is little difference between the effectiveness of various commonly used antihypertensive drugs in people at risk of CVD, according to a recent systematic review and meta-analysis.
	23. 762 Accesses	Research article Problematic internet usage in US college students: a pilot study Dimitri A Christakis, Megan M Moreno, Lauren Jelenchick, Mon T Myaing, Chuan Zhou BMC Medicine 2011, 9:77 (22 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Problematic internet usage is prevalent among US college students, suggesting that colleges should consider preventative measures including awareness campaigns and, as internet usage starts at a young age, pediatricians should also assess this as part of preventative practice.
	24. 735 Accesses	Review Novel therapeutic strategies targeting HIV integrase Peter K Quashie, Richard D Sloan, Mark A Wainberg BMC Medicine 2012, 10:34 (12 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Replication of HIV can be inhibited by viral integrase enzyme inhibitors, and the therapeutic potential of these compounds, as well as the development of novel antiviral drugs are reviewed here by Mark A Wainberg and colleagues.
	25. 731 Accesses	Research article Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab Gang Chen, Peter Kronenberger, Erik Teugels, Ijeoma Umelo, Jacques De Grève BMC Medicine 2012, 10:28 (21 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary siRNA enhances the anti-cancer effects of chemotherapy drugs targeting the EGF receptor in lung cancer cells with drug resistance mutations, highlighting the potential of drug-siRNA combination therapy to overcome resistance.