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	1. 5592 Accesses	Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
	2. 5375 Accesses	Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
	3. 4126 Accesses	Opinion Spectrum of gluten-related disorders: consensus on new nomenclature and classification Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.
	4. 2418 Accesses	Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
	5. 2413 Accesses	Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
	6. 2369 Accesses	Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
	7. 2290 Accesses	Research article How do autoimmune diseases cluster in families? A systematic review and meta-analysis Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga, Juan-Manuel Anaya BMC Medicine 2013, 11:73 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows autoimmune diseases, particularly autoimmune thyroid disease and systemic lupus erythematosus, aggregate in families, indicating that shared genetic factors may be responsible.
	8. 2113 Accesses	Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
	9. 2019 Accesses	Research article Mental illness related disparities in diabetes prevalence, quality of care and outcomes: a population-based longitudinal study Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery, David B Preen BMC Medicine 2011, 9:118 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Disparities in diabetes prevalence and the quality and outcome of diabetic care of those with mental illness and those without in Australia highlights the need for better, more integrated care for this population.
	10. 1993 Accesses	Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
	11. 1886 Accesses	Research article Cross-national epidemiology of DSM-IV major depressive episode Evelyn Bromet, Laura Andrade, Irving Hwang, Nancy A Sampson, Jordi Alonso, Giovanni de Girolamo, Ron de Graaf, Koen Demyttenaere, Chiyi Hu, Noboru Iwata, Aimee N Karam, Jagdish Kaur, Stanislav Kostyuchenko, Jean-Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Mora, Mark Browne, Jose Posada-Villa, Maria Viana, David R Williams, Ronald C Kessler BMC Medicine 2011, 9:90 (26 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Major depression is a significant public health problem around the globe which affects women twice as commonly as men and is most strongly correlated with being separated, divorced or widowed.
	12. 1815 Accesses	Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
	13. 1741 Accesses	Research article Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates IC McManus, A Keeling, E Paice BMC Medicine 2004, 2:29 (18 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Doctors' stress and career satisfaction are partly determined by their different learning styles and can be predicted by studying their personality and habits at medical school.
	14. 1733 Accesses	Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
	15. 1686 Accesses	Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
	16. 1685 Accesses	Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
	17. 1662 Accesses	Research article Anatomy of open access publishing: a study of longitudinal development and internal structure Mikael Laakso, Bo-Christer Björk BMC Medicine 2012, 10:124 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The landscape of scientific publishing has changed during the last decade due to steady growth of open access (OA) journals, as the volume of scientific articles published between 2000-2011 in full immediate OA journals has grown rapidly in relative annual share of published journal articles.
	18. 1599 Accesses	Research article Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsæter BMC Medicine 2013, 11:42 (19 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caffeine intake from various sources during pregnancy is associated with increased risk of the baby being small for gestational age and decreased birth weight, which may have implications for the recommended consumption of caffeine.
	19. 1592 Accesses	Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
	20. 1592 Accesses	Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
	21. 1565 Accesses	Review Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.
	22. 1552 Accesses	Research article Body mass index and incident coronary heart disease in women: a population-based prospective study Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F. Lucy Wright, Jane Green, Gillian Reeves, Valerie Beral, Million Women Study Collaborators BMC Medicine 2013, 11:87 (2 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Coronary heart disease increases with BMI in over 1 million women and this risk is not confounded by age, smoking, physical activity, alcohol consumption and status, suggesting population changes in BMI will reduce the burden of disease.
	23. 1295 Accesses	Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
	24. 1289 Accesses	Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
	25. 1280 Accesses	Research article Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.