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	1.	Research article Alcohol intake, wine consumption and the development of depression: the PREDIMED study Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP BMC Medicine 2013, 11:192 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.
	2.	Opinion Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics Gerwyn Morris, Michael Maes BMC Medicine 2013, 11:205 (17 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary As multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and neuro-immune characteristics, Gerwyn Morris and Michael Maes suggest that CFS should be considered as a neuro-immune disease and that MS patients may be susceptible to develop CFS symptoms.
	3.	Research article A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways Robert P Anderson, Margaret J Henry, Roberta Taylor, Emma L Duncan, Patrick Danoy, Marylia J Costa, Kathryn Addison, Jason A Tye-Din, Mark A Kotowicz, Ross E Knight, Wendy Pollock, Geoffrey C Nicholson, Ban-Hock Toh, Matthew A Brown, Julie A Pasco BMC Medicine 2013, 11:188 (28 August 2013) Abstract \| Full text \| PDF \| Editor’s summary A novel screening approach involving human leukocyte antigen (HLA)-DQ gene testing and confirmatory serology accurately estimates the prevalence of celiac disease (CD), and could help to reduce the number of unnecessary gastroscopies.
	4.	Minireview What is next after the genes for autoimmunity? John Castiblanco, Mauricio Arcos-Burgos, Juan-Manuel Anaya BMC Medicine 2013, 11:197 (4 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Autoimmune diseases have complex etiology and are known to aggregate in families; Juan-Manuel Anaya and colleagues review the genetic components of autoimmunity and discuss the challenges associated with genetic analysis and disease prediction.
	5.	Research article Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review Nicola A Maffiuletti, Marc Roig, Eleftherios Karatzanos, Serafim Nanas BMC Medicine 2013, 11:137 (23 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Critically ill patients in intensive care are prone to muscle weakness and wasting; a systematic review suggests neuromuscular electrical stimulation therapy is effective in preventing muscle weakness, but is inconclusive for muscle wasting.
	6.	Review Personalizing health care: feasibility and future implications Brian Godman, Alexander E Finlayson, Parneet K Cheema, Eva Zebedin-Brandl, Inaki Gutiérrez-Ibarluzea, Jan Jones, Rickard E Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrario, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan Haycox, Harald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Ake Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh et al. BMC Medicine 2013, 11:179 (13 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Brian Godman and colleagues review the challenges and concerns associated with personalized medicine, emphasizing that it has the potential to revolutionize care, but knowledge from a payer’s perspective must be integrated to move forwards.
	7.	Opinion The Hyperferritinemic Syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome Cristina Rosário, Gisele Zandman-Goddard, Esther G Meyron-Holtz, David P D’Cruz, Yehuda Shoenfeld BMC Medicine 2013, 11:185 (22 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yehuda Shoenfeld and colleagues discuss the similar features in macrophage activation syndrome, Still’s disease, antiphospholipid syndrome and septic shock, and propose that they should be grouped together as the Hyperferritinemic Syndrome.
	8.	Commentary Increasing the dose of acute rehabilitation: is there a benefit? Ann M Parker, Robert K Lord, Dale M Needham BMC Medicine 2013, 11:199 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Dale Needham and colleagues comment on results from a clinical trial showing that additional Saturday rehabilitation improves outcome in hospitalized patients, and discuss the motivational benefits of physiotherapy and occupational therapy.
	9.	Opinion So depression is an inflammatory disease, but where does the inflammation come from? Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes BMC Medicine 2013, 11:200 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Depression is associated with a low-grade inflammatory response; Michael Berk and colleagues discuss the sources of inflammation, oxidative and nitrosative stress in depression and emphasize that these factors can be treated or prevented.
	10.	Research article Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management David R Fleisher, Blake Gornowicz, Kathleen Adams, Richard Burch, Edward J Feldman BMC Medicine 2005, 3:20 (21 December 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cyclical Vomiting Syndrome is a little studied but disabling condition, occurring in adults as well as children; appreciation of comorbidities such as migraine, anxiety and inter-episodic dyspeptic nausea may improve diagnosis.
	11.	Research article Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis Rui Liu, Cai-xia Wu, Dan Zhou, Fan Yang, Shuo Tian, Li Zhang, Tian-tai Zhang, Guan-hua Du BMC Medicine 2012, 10:105 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinocembrin, an approved therapy for stroke, improves cognitive function in a mouse model of Alzheimer's disease by downregulation of receptor for advanced glycation end products (RAGE) expression, so could be a new strategy for neuroprotective therapy.
	12.	Opinion Spectrum of gluten-related disorders: consensus on new nomenclature and classification Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.
	13.	Research article Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial Khosrow S Houschyar, Rainer Lüdtke, Gustav J Dobos, Ulrich Kalus, Martina Broecker-Preuss, Thomas Rampp, Benno Brinkhaus, Andreas Michalsen BMC Medicine 2012, 10:54 (30 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Iron reduction by phlebotomy lowers blood pressure and increases insulin sensitivity in patients with metabolic syndrome, suggesting that blood donation can benefit these people by reducing the risk of diabetes and cardiovascular disease.
	14.	Minireview The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department Christian H Nickel, Roland Bingisser, Nils G Morgenthaler BMC Medicine 2012, 10:7 (20 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Morgenthaler and colleagues review the recent progress in determining the prognostic and diagnostic value of copeptin, which is released in response to stress, as a biomarker for risk stratification in the emergency department.
	15.	Review State of progress in treating cystic fibrosis respiratory disease Patrick A Flume, Donald R Van Devanter BMC Medicine 2012, 10:88 (10 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patrick Flume and Donald VanDevanter review the latest developments in determining the pathophysiology of cystic fibrosis (CF), and highlight the improved therapies targeted towards treating lung disease in CF patients.
	16.	Research article Ipsilateral lower extremity joint involvement increases the risk of poor pain and function outcomes after hip or knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:144 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ipsilateral joint involvement is shown to affect pain and function outcomes after total hip or knee arthroplasty, indicating that arthroplasty outcomes may be improved if these issues are addressed.
	17.	Research article Factors associated with patient, and diagnostic delays in Chinese TB patients: a systematic review and meta-analysis Ying Li, John Ehiri, Shenglan Tang, Daikun Li, Yongqiao Bian, Hui Lin, Caitlin Marshall, Jia Cao BMC Medicine 2013, 11:156 (2 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Delays in diagnosing tuberculosis (TB) in China are a major barrier to effective management; a meta-analysis finds these delays are mediated by individual and health system factors, suggesting interventions to raise TB awareness will be useful.
	18.	Review Pharmacological treatments in ARDS; a state-of-the-art update Andrew Boyle, Rob Sweeney, Daniel McAuley BMC Medicine 2013, 11:166 (20 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Current treatment of acute respiratory distress syndrome (ARDS) is limited to minimizing potentially harmful ventilation; Daniel McAuley and colleagues review clinical trials of new agents for ARDS and discuss emerging pharmacological therapies.
	19.	Review Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease Jadwiga A Wedzicha, Simon E Brill, James P Allinson, Gavin C Donaldson BMC Medicine 2013, 11:181 (14 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The frequent exacerbator phenotype is a distinct clinical subgroup in chronic obstructive pulmonary disease (COPD) patients; Jadwiga Wedzicha and colleagues review the pathophysiology of this phenotype and its interaction with other comorbidities.
	20.	Research article Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts, Nicholas F Taylor BMC Medicine 2013, 11:198 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In a clinical trial, additional Saturday rehabilitation improves functional independence and quality of life in hospitalized patients, and could reduce length of hospital stay, suggesting extra rehabilitation should be given to improve patient outcome.
	21.	Research article Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial Estefania Toledo, Frank B Hu, Ramon Estruch, Pilar Buil-Cosiales, Dolores Corella, Jordi Salas-Salvadó, M Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Jose Lapetra, Luis Serra-Majem, Xavier Pinto, Rosa M Lamuela-Raventós, Guillermo Saez, Mònica Bulló, Valentina Ruiz-Gutiérrez, Emilio Ros, José V Sorli, Miguel Martinez-Gonzalez BMC Medicine 2013, 11:207 (19 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In individuals with high cardiovascular disease risk, eating a Mediterranean diet supplemented with olive oil or nuts reduces diastolic blood pressure (BP) more than a low-fat diet, suggesting the Mediterranean diet could be beneficial for BP control.
	22.	Research article Perineal Assessment and Repair Longitudinal Study (PEARLS): a matched-pair cluster randomized trial Khaled M K Ismail, Christine Kettle, Sue E Macdonald, Sue Tohill, Peter W Thomas, Debra Bick BMC Medicine 2013, 11:209 (23 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women with perineal trauma after childbirth have lower risk of wound infection when managed by healthcare practitioners who undergo evidence-based perineal trauma training, suggesting that this training may improve some maternal clinical outcomes.
	23.	Guideline Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update Johan Undén, Tor Ingebrigtsen, Bertil Romner, the Scandinavian Neurotrauma Committee (SNC) BMC Medicine 2013, 11:50 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Scandinavian Neurotrauma Committee presents an evidence and consensus-based update of guidelines for the initial management of minimal, mild and moderate head injuries in adults, but highlight that the recommendations also need to be validated in non-Scandinavaian clinical settings.
	24.	Commentary Do statins lower testosterone and does it matter? Allan D Sniderman, George Thanassoulis BMC Medicine 2013, 11:58 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Allan Sniderman and George Thanassoulis comment on a meta-analysis showing reduction of testosterone by statins, but argue that range of changes rather than average changes need to be considered when measuring the effects of specific drugs.
	25.	Research article A bibliometric analysis of childhood immunization research productivity in Africa since the onset of the Expanded Program on Immunization in 1974 Charles S Wiysonge, Olalekan A Uthman, Peter M Ndumbe, Gregory D Hussey BMC Medicine 2013, 11:66 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Since the onset of the Expanded Program on Immunization, vaccine research productivity in Africa has skewed towards those funded privately, with minimal research input from African authors, suggesting a need for better communication between all stakeholders.