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	1.	Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
	2.	Research article Apps for asthma self-management: a systematic assessment of content and tools Kit Huckvale, Mate Car, Cecily Morrison, Josip Car BMC Medicine 2012, 10:144 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic assessment of apps for asthma self-management finds that none combine reliable information with appropriate supportive tools, thus physicians considering recommending these should apply caution as some apps may be unsafe.
	3.	Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
	4.	Review Novel aspects of Sjögren’s syndrome in 2012 Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld BMC Medicine 2013, 11:93 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Angela Tincani and colleagues review the latest developments in Sjogren's Syndrome research and therapies, and highlight a possible link between Vitamin D levels and development of the disease.
	5.	Research article Targeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life Riku Nikander, Harri Sievänen, Ari Heinonen, Robin M Daly, Kirsti Uusi-Rasi, Pekka Kannus BMC Medicine 2010, 8:47 (21 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Long-term supervised exercise appears to substantially increase lower extremity bone strength in children, an augmentation not observed in adults, increasing the need for improved studies to more closely examine this phenomenon.
	6.	Review Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.
	7.	Research article Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis Rui Liu, Cai-xia Wu, Dan Zhou, Fan Yang, Shuo Tian, Li Zhang, Tian-tai Zhang, Guan-hua Du BMC Medicine 2012, 10:105 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinocembrin, an approved therapy for stroke, improves cognitive function in a mouse model of Alzheimer's disease by downregulation of receptor for advanced glycation end products (RAGE) expression, so could be a new strategy for neuroprotective therapy.
	8.	Review Using lithium as a neuroprotective agent in patients with cancer Mustafa Khasraw, David Ashley, Greg Wheeler, Michael Berk BMC Medicine 2012, 10:131 (2 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mustafa Khasraw and colleagues review the toxic effects of radiotherapy and chemotherapy, and explore recent evidence which indicates lithium can be used to protect against the neurocognitive decline in cancer patients receiving cranial radiation.
	9.	Commentary Location, location, location: the BRMS1 protein and melanoma progression Adam I Riker, Rajeev S Samant BMC Medicine 2012, 10:19 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Riker and Samant comment on a study in BMC Cancer showing that the intracellular location of BRMS1 determines the metastatic potential of melanoma, and discuss how therapies can be developed to target the location of this important protein.
	10.	Opinion The role of nutrition in integrated programs to control neglected tropical diseases Andrew Hall, Yaobi Zhang, Chad MacArthur, Shawn Baker BMC Medicine 2012, 10:41 (25 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Neglected tropical diseases (NTDs) are prevalent in malnourished populations and are exacerbated by undernutrition; Andrew Hall and colleagues propose that the efficacy of NTD control programs can be increased by including nutritional interventions.
	11.	Opinion Towards a genuinely medical model for psychiatric nosology Randolph M Nesse, Dan J Stein BMC Medicine 2012, 10:5 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary With the imminent release of the DSM-5, Nesse and Stein discuss the ways that classifications of disease in psychiatry still fall short of the ideal, and argue for a more medical approach to this subject.
	12.	Minireview New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids Michel de Lorgeril, Patricia Salen BMC Medicine 2012, 10:50 (21 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary de Lorgeril and Salen review recent findings on the effects of different types of dietary fats on cardiovascular disease and cancer, concluding that low intake of omega-6 reduces disease risk due to its link with breast cancer.
	13.	Research article Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer Robert S Phillips, Ros Wade, Thomas Lehrnbecher, Lesley A Stewart, Alex J Sutton BMC Medicine 2012, 10:6 (18 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis suggests inconclusive predictive value of serum biomarkers for pediatric febrile neutropenic episodes, but further studies for the roles of IL6, IL8 and procalcitonin should be conducted.
	14.	Research article Month of birth, vitamin D and risk of immune-mediated disease: a case control study Giulio Disanto, George Chaplin, Julia M Morahan, Gavin Giovannoni, Elina Hyppönen, George C Ebers, Sreeram V Ramagopalan BMC Medicine 2012, 10:69 (6 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A large study finds a link between month of birth and prevalence of common immune-mediated diseases, which may be mediated by UVB light exposure and vitamin D status during gestation, providing insight for disease prevention strategies.
	15.	Review The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence Rozalia Dimitriou, George I Mataliotakis, Giorgio Calori, Peter V Giannoudis BMC Medicine 2012, 10:81 (26 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Healing of large bone defects is challenging, but barrier membranes are being developed to treat these in a single step; Peter Giannoudis and colleagues review clinical evidence on the regenerative properties of membranes and highlight the need for further research.
	16.	Commentary The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? Eleftherios P Diamandis BMC Medicine 2012, 10:87 (9 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Despite the discovery of many biomarkers for cancer diagnosis and prognosis, very few have been used within the clinical setting; Eleftherios Diamandis explains the reasons behind the incongruity, discussing potential solutions for this issue.
	17.	Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
	18.	Research article Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens BMC Medicine 2013, 11:105 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caregivers’ awareness of dementia as a terminal disease is associated with better patient comfort, suggesting that educating the families of dementia sufferers is important to ensure appropriate planning is undertaken to improve the care of these patients.
	19.	Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
	20.	Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
	21.	Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
	22.	Research article Characteristics, changes and influence of body composition during a 4486km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
	23.	Guideline RAMESES publication standards: meta-narrative reviews Geoff Wong, Trish Greenhalgh, Gill Westhorp, Jeanette Buckingham, Ray Pawson BMC Medicine 2013, 11:20 (29 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Geoff Wong, Trish Greenhalgh et al. propose new publication guidelines for realist synthesis and meta-narrative reviews. The ‘RAMESES’ (Realist and Meta-review Evidence Synthesis: Evolving Standards) statement provides researchers, institutes and journals with guidance on how to conduct these new forms of literature analysis, and adherence to the guidelines will lead to quality assurance and uniform reporting of studies.
	24.	Opinion Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? Michel de Lorgeril, Patricia Salen, Pascal Defaye, Mikael Rabaeus BMC Medicine 2013, 11:5 (4 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Michel de Lorgeril and colleagues review contrasting evidence on the health benefits of omega-3 fatty acids (n-3), and discuss how n-3 may be ineffective in statin users due to complex interactions between the two compounds.
	25.	Guideline Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update Johan Undén, Tor Ingebrigtsen, Bertil Romner, the Scandinavian Neurotrauma Committee (SNC) BMC Medicine 2013, 11:50 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Scandinavian Neurotrauma Committee presents an evidence and consensus-based update of guidelines for the initial management of minimal, mild and moderate head injuries in adults, but highlight that the recommendations also need to be validated in non-Scandinavaian clinical settings.