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		Research article Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis Rui Liu, Cai-xia Wu, Dan Zhou, Fan Yang, Shuo Tian, Li Zhang, Tian-tai Zhang, Guan-hua Du BMC Medicine 2012, 10:105 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinocembrin, an approved therapy for stroke, improves cognitive function in a mouse model of Alzheimer's disease by downregulation of receptor for advanced glycation end products (RAGE) expression, so could be a new strategy for neuroprotective therapy.
		Review New treatments for influenza Sailen Barik BMC Medicine 2012, 10:104 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is a continuing need for new influenza therapy due to the rapid evolution of viral resistance to treatment; Sailen Barik reviews the development of novel anti-influenza drugs based on molecular targets and genomic advances.
		Correspondence A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas Caroline Kampf, Julia Bergman, Per Oksvold, Anna Asplund, Sanjay Navani, Mikaela Wiking, Emma Lundberg, Mathias Uhlén, Fredrik Ponten BMC Medicine 2012, 10:103 (12 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fredrik Ponten and colleagues highlight how a tissue dictionary recently developed to accompany the Human Protein Atlas (HPA), can be used by clinicians for diagnostic and biomarker studies in cancer pathology.
		Research article Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study Bernd Kronenberger, Ina Rudloff, Malte Bachmann, Friederike Brunner, Lisa Kapper, Natalie Filmann, Oliver Waidmann, Eva Herrmann, Josef Pfeilschifter, Stefan Zeuzem, Albrecht Piiper, Heiko Mühl BMC Medicine 2012, 10:102 (11 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elevated interleukin-22 (IL-22) levels predict reduced survival in patients with advanced liver cirrhosis independently from age, C-reactive protein, disease severity and complications, suggesting that IL-22 could be used as a prognostic marker.
		Research article Transforming growth factor β₁inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? Sabrina Ehnert, Jian Zhao, Stefan Pscherer, Thomas Freude, Steven Dooley, Andreas Kolk, Ulrich Stöckle, Andreas Nussler, Robert Hube BMC Medicine 2012, 10:101 (7 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bone morphogenic proteins (BMPs), used to aid fracture healing, do not work on some patients due to an increase in histone deacetylase (HDAC) activity, so inhibiting HDAC activity in combination with BMP therapy may aid healing.
		Debate Integrating pathology and radiology disciplines: an emerging opportunity? James Sorace, Denise R Aberle, Dena Elimam, Silvana Lawvere, Ossama Tawfik, W Dean Wallace BMC Medicine 2012, 10:100 (5 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pathology and radiology are central to cancer diagnosis, but the two disciplines are often separated; James Sorace and colleagues suggest development of an integrated diagnostic system combining the two specialties to improve quality of patient care.
		Research article A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment Monica Shaw, Paul Hodgkins, Hervé Caci, Susan Young, Jennifer Kahle, Alisa G Woods, L Eugene Arnold BMC Medicine 2012, 10:99 (4 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a systematic review, Monica Shaw et al analyse the effects of treatment on long-term functional improvement of attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults, and show that those on treatment exhibit improved outcomes when compared to their untreated counterparts.
		Research article Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Shan-Shan Zhang, Jing Hou, Yan Liu, Rong Li, Lu Gao, Xue Zhao, Qiu-Dong Zhao, Meng-Chao Wu, Li-Xin Wei BMC Medicine 2012, 10:98 (31 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Toll-like receptor 4 is required for lipopolysaccharide-induced metastasis in hepatocellular carcinoma cells and is associated with poor survival in patients, signifying its potential as a prognostic marker and therapeutic target.
		Research article Intracranial hemorrhage in adult patients with hematological malignancies Chien-Yuan Chen, Chan-Hwei Tai, Aristine Cheng, Hung-Chang Wu, Woei Tsay, Jia-Hau Liu, Pey-Ying Chen, Shang-Yi Huang, Ming Yao, Jih-Luh Tang, Hwei-Fang Tien BMC Medicine 2012, 10:97 (29 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intracranial hemorrhage (ICH) is more common in patients with acute myeloid leukemia compared with other hematological malignancies, suggesting that these patients should be monitored for ICH to assess prognosis and guide treatment strategies.
		Research article Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review Frank Kunath, Bastian Keck, Gerd Antes, Bernd Wullich, Joerg J Meerpohl BMC Medicine 2012, 10:96 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that tamoxifen is effective for the prevention and treatment of breast events in men undergoing anti-androgen treatment for prostate cancer, although dose and long-term adverse effects need to be determined.
		Review Physiopathology of intratendinous calcific deposition Francesco Oliva, Alessio Via, Nicola Maffulli BMC Medicine 2012, 10:95 (23 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The etiopathogenesis of calcific tendinopathy is controversial and therapeutic development relies on further research; Nicola Maffulli and colleagues review the current theories and recent evidence to explain the underlying causes of this complex condition.
		Research article Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model Bum Kim, So Chun, Jong Lee, Hyun Lim, Jae-sung Bae, Ho-Yun Chung, Anthony Atala, Shay Soker, James J Yoo, Tae Kwon BMC Medicine 2012, 10:94 (21 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human amniotic fluid stem cells can differentiate into muscle cells and restore urethral sphincter function in a mouse model of stress urinary incontinence (SUI), suggesting that they could be a new non-invasive therapeutic option for SUI.
		Review Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences Witold Czyz, Julia M Morahan, George C Ebers, Sreeram V Ramagopalan BMC Medicine 2012, 10:93 (17 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Monozygotic twins inherit identical genomes, but they can have phenotypic differences, traditionally explained by non-shared environmental factors; George Ebers and colleagues review other reasons behind discordance, focusing on epigenetics.
		Debate Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits Bjørn H Ebdrup, Filip K Knop, Pelle L Ishøy, Egill Rostrup, Birgitte Fagerlund, Henrik Lublin, Birte Glenthøj BMC Medicine 2012, 10:92 (15 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Overweight is a major side effect of antipsychotic drugs so Bjørn H Ebdrup et al. propose analogs of glucagon-like peptide-1, which cause weight loss in diabetics, can be used to treat antipsychotic-induced weight gain in schizophrenic patients.
		Research article Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial Michael Berk, Olivia M Dean, Sue M Cotton, Clarissa S Gama, Flavio Kapczinski, Brisa Fernandes, Kristy Kohlmann, Susan Jeavons, Karen Hewitt, Kirsteen Moss, Christine Allwang, Ian Schapkaitz, Heidi Cobb, Ashley I Bush, Seetal Dodd, Gin S Malhi BMC Medicine 2012, 10:91 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a clinical trial suggests that N-acetyl cysteine, which has previously demonstrated antidepressant properties, does not have long-term efficacy for bipolar disorder, in contrast to the results of a previous trial.
		Commentary A mathematical model to guide antibiotic treatment strategies Albert Sotto, Jean-Philippe Lavigne BMC Medicine 2012, 10:90 (13 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sotto and Lavigne comment on a study showing that mechanisms of antibiotic resistance should be taken into account to guide treatment strategies, and discuss how a multidisciplinary approach should be used to overcome multidrug-resistant infections.
		Research article Implications of stress-induced genetic variation for minimizing multidrug resistance in bacteria Uri Obolski, Lilach Hadany BMC Medicine 2012, 10:89 (13 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A mathematical model shows that cycling and mixing strategies are effective against antibiotic-resistant infection when resistance occurs via horizontal gene transfer, suggesting that resistance mechanism should be considered in treatment decisions.
		Review State of progress in treating cystic fibrosis respiratory disease Patrick A Flume, Donald R Van Devanter BMC Medicine 2012, 10:88 (10 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patrick Flume and Donald VanDevanter review the latest developments in determining the pathophysiology of cystic fibrosis (CF), and highlight the improved therapies targeted towards treating lung disease in CF patients.
		Commentary The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? Eleftherios P Diamandis BMC Medicine 2012, 10:87 (9 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Despite the discovery of many biomarkers for cancer diagnosis and prognosis, very few have been used within the clinical setting; Eleftherios Diamandis explains the reasons behind the incongruity, discussing potential solutions for this issue.
		Research article Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review Sileny N Han, Anouk Lotgerink, Mina Gziri, Kristel Van Calsteren, Myriam Hanssens, Frédéric Amant BMC Medicine 2012, 10:86 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that gynecological tumor marker levels can increase during normal pregnancy, indicating that elevated markers alone should not lead to invasive diagnostic procedures that could put the fetus at risk.
		Research article CD133⁺CXCR4⁺colon cancer cells exhibit metastatic potential and predict poor prognosis of patients Shan-shan Zhang, Zhi-peng Han, Ying-ying Jing, Shuang-fen Tao, Tie-jun Li, Hao Wang, Yang Wang, Rong Li, Yang Yang, Xue Zhao, Xiao-dong Xu, En-da Yu, Yao-cheng Rui, Hou-jia Liu, Li Zhang, Li-xin Wei BMC Medicine 2012, 10:85 (7 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Colon cancer cells expressing CD133 and CXCR4 are associated with metastasis and reduced survival in patients, and blocking CXCR4 in a mouse model inhibits tumor growth, which suggests that these proteins could be targeted in colon cancer therapy.
		Research article Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker Der-Yuan Chen, Huai-Chia Chuang, Joung-Liang Lan, Yi-Ming Chen, Wei-Ting Hung, Kuo-Lung Lai, Tse-Hua Tan BMC Medicine 2012, 10:84 (6 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Disease activity of adult-onset Still's disease, a rare form of inflammatory arthritis, can be measured by using levels of germinal center kinase-like kinase (GLK) as a biomarker for pathogenesis, which can be useful in establishing therapy efficacy.
		Commentary Medicine, morality and health care social media Farris K Timimi BMC Medicine 2012, 10:83 (2 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Farris Timimi comments on the growing popularity of social media, and discusses how this can be used as an effective tool for physicians to help patients gain better understanding about clinical research.
		Research article Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study Nienke Lesuis, Ragnar Befrits, Filippa Nyberg, Ronald F van Vollenhoven BMC Medicine 2012, 10:82 (1 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women have more severe disease than men before treatment for rheumatoid arthritis, psoriasis and inflammatory bowel disease, suggesting that immune-mediated diseases have a greater effect on women, which could inform future treatment decisions.
		Review The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence Rozalia Dimitriou, George I Mataliotakis, Giorgio Calori, Peter V Giannoudis BMC Medicine 2012, 10:81 (26 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Healing of large bone defects is challenging, but barrier membranes are being developed to treat these in a single step; Peter Giannoudis and colleagues review clinical evidence on the regenerative properties of membranes and highlight the need for further research.

	All
		Research article Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis Rui Liu, Cai-xia Wu, Dan Zhou, Fan Yang, Shuo Tian, Li Zhang, Tian-tai Zhang, Guan-hua Du BMC Medicine 2012, 10:105 (18 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinocembrin, an approved therapy for stroke, improves cognitive function in a mouse model of Alzheimer's disease by downregulation of receptor for advanced glycation end products (RAGE) expression, so could be a new strategy for neuroprotective therapy.
		Review New treatments for influenza Sailen Barik BMC Medicine 2012, 10:104 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is a continuing need for new influenza therapy due to the rapid evolution of viral resistance to treatment; Sailen Barik reviews the development of novel anti-influenza drugs based on molecular targets and genomic advances.
		Correspondence A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas Caroline Kampf, Julia Bergman, Per Oksvold, Anna Asplund, Sanjay Navani, Mikaela Wiking, Emma Lundberg, Mathias Uhlén, Fredrik Ponten BMC Medicine 2012, 10:103 (12 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fredrik Ponten and colleagues highlight how a tissue dictionary recently developed to accompany the Human Protein Atlas (HPA), can be used by clinicians for diagnostic and biomarker studies in cancer pathology.
		Research article Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study Bernd Kronenberger, Ina Rudloff, Malte Bachmann, Friederike Brunner, Lisa Kapper, Natalie Filmann, Oliver Waidmann, Eva Herrmann, Josef Pfeilschifter, Stefan Zeuzem, Albrecht Piiper, Heiko Mühl BMC Medicine 2012, 10:102 (11 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elevated interleukin-22 (IL-22) levels predict reduced survival in patients with advanced liver cirrhosis independently from age, C-reactive protein, disease severity and complications, suggesting that IL-22 could be used as a prognostic marker.
		Research article Transforming growth factor β₁inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? Sabrina Ehnert, Jian Zhao, Stefan Pscherer, Thomas Freude, Steven Dooley, Andreas Kolk, Ulrich Stöckle, Andreas Nussler, Robert Hube BMC Medicine 2012, 10:101 (7 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bone morphogenic proteins (BMPs), used to aid fracture healing, do not work on some patients due to an increase in histone deacetylase (HDAC) activity, so inhibiting HDAC activity in combination with BMP therapy may aid healing.
		Debate Integrating pathology and radiology disciplines: an emerging opportunity? James Sorace, Denise R Aberle, Dena Elimam, Silvana Lawvere, Ossama Tawfik, W Dean Wallace BMC Medicine 2012, 10:100 (5 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pathology and radiology are central to cancer diagnosis, but the two disciplines are often separated; James Sorace and colleagues suggest development of an integrated diagnostic system combining the two specialties to improve quality of patient care.
		Research article A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment Monica Shaw, Paul Hodgkins, Hervé Caci, Susan Young, Jennifer Kahle, Alisa G Woods, L Eugene Arnold BMC Medicine 2012, 10:99 (4 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a systematic review, Monica Shaw et al analyse the effects of treatment on long-term functional improvement of attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults, and show that those on treatment exhibit improved outcomes when compared to their untreated counterparts.
		Research article Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Shan-Shan Zhang, Jing Hou, Yan Liu, Rong Li, Lu Gao, Xue Zhao, Qiu-Dong Zhao, Meng-Chao Wu, Li-Xin Wei BMC Medicine 2012, 10:98 (31 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Toll-like receptor 4 is required for lipopolysaccharide-induced metastasis in hepatocellular carcinoma cells and is associated with poor survival in patients, signifying its potential as a prognostic marker and therapeutic target.
		Research article Intracranial hemorrhage in adult patients with hematological malignancies Chien-Yuan Chen, Chan-Hwei Tai, Aristine Cheng, Hung-Chang Wu, Woei Tsay, Jia-Hau Liu, Pey-Ying Chen, Shang-Yi Huang, Ming Yao, Jih-Luh Tang, Hwei-Fang Tien BMC Medicine 2012, 10:97 (29 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intracranial hemorrhage (ICH) is more common in patients with acute myeloid leukemia compared with other hematological malignancies, suggesting that these patients should be monitored for ICH to assess prognosis and guide treatment strategies.
		Research article Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review Frank Kunath, Bastian Keck, Gerd Antes, Bernd Wullich, Joerg J Meerpohl BMC Medicine 2012, 10:96 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that tamoxifen is effective for the prevention and treatment of breast events in men undergoing anti-androgen treatment for prostate cancer, although dose and long-term adverse effects need to be determined.
		Review Physiopathology of intratendinous calcific deposition Francesco Oliva, Alessio Via, Nicola Maffulli BMC Medicine 2012, 10:95 (23 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The etiopathogenesis of calcific tendinopathy is controversial and therapeutic development relies on further research; Nicola Maffulli and colleagues review the current theories and recent evidence to explain the underlying causes of this complex condition.
		Research article Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model Bum Kim, So Chun, Jong Lee, Hyun Lim, Jae-sung Bae, Ho-Yun Chung, Anthony Atala, Shay Soker, James J Yoo, Tae Kwon BMC Medicine 2012, 10:94 (21 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human amniotic fluid stem cells can differentiate into muscle cells and restore urethral sphincter function in a mouse model of stress urinary incontinence (SUI), suggesting that they could be a new non-invasive therapeutic option for SUI.
		Review Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences Witold Czyz, Julia M Morahan, George C Ebers, Sreeram V Ramagopalan BMC Medicine 2012, 10:93 (17 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Monozygotic twins inherit identical genomes, but they can have phenotypic differences, traditionally explained by non-shared environmental factors; George Ebers and colleagues review other reasons behind discordance, focusing on epigenetics.
		Debate Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits Bjørn H Ebdrup, Filip K Knop, Pelle L Ishøy, Egill Rostrup, Birgitte Fagerlund, Henrik Lublin, Birte Glenthøj BMC Medicine 2012, 10:92 (15 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Overweight is a major side effect of antipsychotic drugs so Bjørn H Ebdrup et al. propose analogs of glucagon-like peptide-1, which cause weight loss in diabetics, can be used to treat antipsychotic-induced weight gain in schizophrenic patients.
		Research article Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial Michael Berk, Olivia M Dean, Sue M Cotton, Clarissa S Gama, Flavio Kapczinski, Brisa Fernandes, Kristy Kohlmann, Susan Jeavons, Karen Hewitt, Kirsteen Moss, Christine Allwang, Ian Schapkaitz, Heidi Cobb, Ashley I Bush, Seetal Dodd, Gin S Malhi BMC Medicine 2012, 10:91 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a clinical trial suggests that N-acetyl cysteine, which has previously demonstrated antidepressant properties, does not have long-term efficacy for bipolar disorder, in contrast to the results of a previous trial.
		Commentary A mathematical model to guide antibiotic treatment strategies Albert Sotto, Jean-Philippe Lavigne BMC Medicine 2012, 10:90 (13 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sotto and Lavigne comment on a study showing that mechanisms of antibiotic resistance should be taken into account to guide treatment strategies, and discuss how a multidisciplinary approach should be used to overcome multidrug-resistant infections.
		Research article Implications of stress-induced genetic variation for minimizing multidrug resistance in bacteria Uri Obolski, Lilach Hadany BMC Medicine 2012, 10:89 (13 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A mathematical model shows that cycling and mixing strategies are effective against antibiotic-resistant infection when resistance occurs via horizontal gene transfer, suggesting that resistance mechanism should be considered in treatment decisions.
		Review State of progress in treating cystic fibrosis respiratory disease Patrick A Flume, Donald R Van Devanter BMC Medicine 2012, 10:88 (10 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patrick Flume and Donald VanDevanter review the latest developments in determining the pathophysiology of cystic fibrosis (CF), and highlight the improved therapies targeted towards treating lung disease in CF patients.
		Commentary The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? Eleftherios P Diamandis BMC Medicine 2012, 10:87 (9 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Despite the discovery of many biomarkers for cancer diagnosis and prognosis, very few have been used within the clinical setting; Eleftherios Diamandis explains the reasons behind the incongruity, discussing potential solutions for this issue.
		Research article Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review Sileny N Han, Anouk Lotgerink, Mina Gziri, Kristel Van Calsteren, Myriam Hanssens, Frédéric Amant BMC Medicine 2012, 10:86 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that gynecological tumor marker levels can increase during normal pregnancy, indicating that elevated markers alone should not lead to invasive diagnostic procedures that could put the fetus at risk.
		Research article CD133⁺CXCR4⁺colon cancer cells exhibit metastatic potential and predict poor prognosis of patients Shan-shan Zhang, Zhi-peng Han, Ying-ying Jing, Shuang-fen Tao, Tie-jun Li, Hao Wang, Yang Wang, Rong Li, Yang Yang, Xue Zhao, Xiao-dong Xu, En-da Yu, Yao-cheng Rui, Hou-jia Liu, Li Zhang, Li-xin Wei BMC Medicine 2012, 10:85 (7 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Colon cancer cells expressing CD133 and CXCR4 are associated with metastasis and reduced survival in patients, and blocking CXCR4 in a mouse model inhibits tumor growth, which suggests that these proteins could be targeted in colon cancer therapy.
		Research article Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker Der-Yuan Chen, Huai-Chia Chuang, Joung-Liang Lan, Yi-Ming Chen, Wei-Ting Hung, Kuo-Lung Lai, Tse-Hua Tan BMC Medicine 2012, 10:84 (6 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Disease activity of adult-onset Still's disease, a rare form of inflammatory arthritis, can be measured by using levels of germinal center kinase-like kinase (GLK) as a biomarker for pathogenesis, which can be useful in establishing therapy efficacy.
		Commentary Medicine, morality and health care social media Farris K Timimi BMC Medicine 2012, 10:83 (2 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Farris Timimi comments on the growing popularity of social media, and discusses how this can be used as an effective tool for physicians to help patients gain better understanding about clinical research.
		Research article Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study Nienke Lesuis, Ragnar Befrits, Filippa Nyberg, Ronald F van Vollenhoven BMC Medicine 2012, 10:82 (1 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women have more severe disease than men before treatment for rheumatoid arthritis, psoriasis and inflammatory bowel disease, suggesting that immune-mediated diseases have a greater effect on women, which could inform future treatment decisions.
		Review The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence Rozalia Dimitriou, George I Mataliotakis, Giorgio Calori, Peter V Giannoudis BMC Medicine 2012, 10:81 (26 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Healing of large bone defects is challenging, but barrier membranes are being developed to treat these in a single step; Peter Giannoudis and colleagues review clinical evidence on the regenerative properties of membranes and highlight the need for further research.