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		Review Using lithium as a neuroprotective agent in patients with cancer Mustafa Khasraw, David Ashley, Greg Wheeler, Michael Berk BMC Medicine 2012, 10:131 (2 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mustafa Khasraw and colleagues review the toxic effects of radiotherapy and chemotherapy, and explore recent evidence which indicates lithium can be used to protect against the neurocognitive decline in cancer patients receiving cranial radiation.
		Research article How evidence-based is an 'evidence-based parenting program'? A PRISMA systematic review and meta-analysis of Triple P Philip Wilson, Robert Rush, Susan Hussey, Christine Puckering, Fiona Sim, Clare S Allely, Paul Doku, Alex McConnachie, Christopher Gillberg BMC Medicine 2012, 10:130 (2 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A systematic review and meta-analysis on the outcomes of the Triple P positive parenting programme, indicates long-term effectiveness has not been adequately assessed, and highlights a thorough review of the system is needed before further implementation of the programme is approved.
		Research article Perinatal nicotine exposure induces asthma in second generation offspring Virender K Rehan, Jie Liu, Erum Naeem, Jia Tian, Reiko Sakurai, Kenny Kwong, Omid Akbari, John S Torday BMC Medicine 2012, 10:129 (30 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Smoking during pregnancy induces asthma in offspring, and the effects are permanently transmitted to subsequent generations via epigenetic changes in germ cells, providing a breakthrough in studying transgenerational effects of toxins.
		Research article Prevalence and incidence density rates of chronic comorbidity in type 2 diabetes patients: an exploratory cohort study Hilde Luijks, Tjard Schermer, Hans Bor, Chris van Weel, Toine Lagro-Janssen, Marion Biermans, Wim de Grauw BMC Medicine 2012, 10:128 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comorbidities such as cardiovascular, musculoskeletal and mental diseases are common among those suffering from type 2 diabetes and could interfere with disease management, so diabetes guidelines should take these comorbidities into account.
		Opinion Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals Maciej J Lazarczyk, Patrick R Hof, Constantin Bouras, Panteleimon Giannakopoulos BMC Medicine 2012, 10:127 (25 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Giannakopoulos and colleagues review the latest advances in biomarker discovery for diagnosis of preclinical Alzheimer's disease (AD), but caution against an assumption of AD development, as some subjects who test positive for the biomarkers may never go on to develop AD-related dementia.
		Commentary Health surveillance of deployed military personnel occasionally leads to unexpected findings Alexander C McFarlane BMC Medicine 2012, 10:126 (24 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alexander McFarlane discusses the need for military personnel with serious medical illness to receive equal psychiatric monitoring as those who suffer from combat injuries, as a recent study shows that both groups have a similar risk of developing post-traumatic stress disorder.
		Research article Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis Xuefeng B Ling, Claudia Macaubas, Heather C Alexander, Qiaojun Wen, Edward Chen, Sihua Peng, Yue Sun, Chetan Deshpande, Kuang-Hung Pan, Richard Lin, Chih-Jian Lih, Sheng-Yung P Chang, Tzielan Lee, Christy Sandborg, Ann B Begovich, Stanley N Cohen, Elizabeth D Mellins BMC Medicine 2012, 10:125 (23 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genes related to inflammation are differentially expressed in systemic and polyarticular juvenile idiopathic arthritis, suggesting that distinct immunobiology underlies their clinical phenotypes, which may aid in finding disease-tailored therapy.
		Research article Anatomy of open access publishing: a study of longitudinal development and internal structure Mikael Laakso, Bo-Christer Björk BMC Medicine 2012, 10:124 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The landscape of scientific publishing has changed during the last decade due to steady growth of open access (OA) journals, as the volume of scientific articles published between 2000-2011 in full immediate OA journals has grown rapidly in relative annual share of published journal articles.
		Research article Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies Steven Moylan, Felice N Jacka, Julie A Pasco, Michael Berk BMC Medicine 2012, 10:123 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review shows that smoking and nicotine dependence increase an individual?s risk of panic disorder and generalized anxiety disorder, but inconsistent evidence exists on whether increased anxiety is associated with these behaviors.
		Research article Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation Pedro Bullon, Mario Cordero, José Quiles, Maria Ramirez-Tortosa, Adrian Gonzalez-Alonso, Simona Alfonsi, Rocio García-Marín, Manuel de Miguel, Maurizio Battino BMC Medicine 2012, 10:122 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with periodontitis exhibit reactive oxidation species mediated autophagy, suggesting that autophagy may play a key role in the progression of inflammatory diseases.
		Commentary Making mobility-related disability better: a complex response to a complex problem Kenneth Rockwood BMC Medicine 2012, 10:121 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mobility-related disability in frail older people has been found to be reduced in a recent clinical trial; Kenneth Rockwood comments on understanding the complex needs of these individuals to provide effective treatment and a better quality of life.
		Research article Effect of a multifactorial interdisciplinary intervention on mobility-related disability in frail older people: randomised controlled trial Nicola Fairhall, Catherine Sherrington, Susan E Kurrle, Stephen R Lord, Keri Lockwood, Ian D Cameron BMC Medicine 2012, 10:120 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Frail elderly participants on a 12-month multifactorial interdisciplinary program experience reduced mobility-related disability at both the participation and activity levels, and can therefore be more independent than those who receive only usual care.
		Research article Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis Wei Bao, Ying Rong, Shuang Rong, Liegang Liu BMC Medicine 2012, 10:119 (10 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review and meta-analysis finds increased body iron stores and higher heme iron intake are linked to a higher risk of type 2 diabetes, while non-heme iron intake is not, suggesting that caution needs to be applied in the type and amount of iron supplementation.
		Commentary Toward unbiased assessment of treatment and prevention: modeling household transmission of pandemic influenza Gerardo Chowell, Hiroshi Nishiura BMC Medicine 2012, 10:118 (9 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Accounting for high household variability in a new mathematical model better predicts influenza spread; Gerardo Chowell and Hiroshi Nishiura discuss how unbiased modeling can lead to improved design and delivery of the interventions needed to control an outbreak.
		Research article Estimation of outbreak severity and transmissibility: Influenza A(H1N1)pdm09 in households Thomas House, Nadia Inglis, Joshua V Ross, Fay Wilson, Shakeel Suleman, Obaghe Edeghere, Gillian Smith, Babatunde Olowokure, Matt J Keeling BMC Medicine 2012, 10:117 (9 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new mathematical model to estimate influenza spread accounts for high variability in outcomes by assessing differences in household size and transmissibility rates, therefore providing more comprehensive information to public health policy makers.
		Minireview Personalized medicine in multiple sclerosis: hope or reality? Tobias Derfuss BMC Medicine 2012, 10:116 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tobias Derfuss reviews the progress made in biomarker discovery for multiple sclerosis and discusses how this can help develop a more personalized approach towards treatment of this highly heterogeneous disease.
		Minireview ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients? Christie M Lee, Eddy Fan BMC Medicine 2012, 10:115 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intensive care unit-acquired weakness (ICUAW) is a problem for critical care patients and is exacerbated by barriers against rehabilitation; Eddy Fan and Christie Lee discuss the risk factors for ICUAW, as well as the benefits of early mobility.
		Commentary Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication Eric J Arts BMC Medicine 2012, 10:114 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eric Arts comments on the findings of a recent study which can have major implications on the treatment strategy for newly infected HIV patients carrying highly virulent strains of the virus.
		Review Stroke genetics: prospects for personalized medicine Hugh S Markus BMC Medicine 2012, 10:113 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hugh Markus reviews the latest developments in stroke genetics, highlighting how the variants identified confer only a small risk of disease, and describes how pharmacogenomic approaches can be applied for patient-tailored therapy.
		Review Renal cancer biomarkers: the promise of personalized care Naveen S Vasudev, Peter J Selby, Rosamonde E Banks BMC Medicine 2012, 10:112 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rosamonde Banks and colleagues review recent advances in the genetics and epigenetics of renal cell carcinoma, and discuss how personalized care is being developed through the characterization of biomarkers in the clinic.
		Commentary Is diagnosis enough to guide interventions in mental health? Using case formulation in clinical practice Craig A Macneil, Melissa K Hasty, Philippe Conus, Michael Berk BMC Medicine 2012, 10:111 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Craig Macneil and colleagues comment on the need for clinicians to take a personalized approach when treating patients with mental health disorders, so that the most appropriate intervention can be selected for patients by taking their individual factors into account.
		Commentary Individual differences and evidence-based psychopharmacology RH Belmaker, Yuly Bersudsky, Galila Agam BMC Medicine 2012, 10:110 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Robert Belmaker and colleagues comment on the importance of understanding individual differences for effective drug treatment of psychiatric disorders, and emphasize that patient heterogeneity should be reported in randomised clinical trials.
		Commentary The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention Giovanni Lughezzani BMC Medicine 2012, 10:109 (25 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Obese patients with prostate cancer have altered gene expression in periprostatic adipose tissue compared to patients who are lean; Giovanni Lughezzani comments on this, suggesting that the resultant change in microenvironment may influence cancer progression.
		Research article Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue Ricardo Ribeiro, Cátia Monteiro, Victoria Catalán, Pingzhao Hu, Virgínia Cunha, Amaia Rodríguez, Javier Gómez-Ambrosi, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vitor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Carlos Lopes, Rui Medeiros, Gema Frühbeck BMC Medicine 2012, 10:108 (25 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Obese patients with prostate cancer (PC) have different gene expression in their periprostatic adipose tissue compared to lean patients, which promotes a favorable environment for tumor progression by crosstalk between this tissue and the cancer cells.
		Minireview Epilepsy care guidelines for low- and middle- income countries: From WHO mental health GAP to national programs Juri Katchanov, Gretchen L Birbeck BMC Medicine 2012, 10:107 (24 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Juri Katchanov and Gretchen Birbeck discuss the differing needs of low- and middle-income countries for epilepsy care guidelines compared with higher income countries, and describe how successful execution requires local adaptation.

	All
		Review Using lithium as a neuroprotective agent in patients with cancer Mustafa Khasraw, David Ashley, Greg Wheeler, Michael Berk BMC Medicine 2012, 10:131 (2 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mustafa Khasraw and colleagues review the toxic effects of radiotherapy and chemotherapy, and explore recent evidence which indicates lithium can be used to protect against the neurocognitive decline in cancer patients receiving cranial radiation.
		Research article How evidence-based is an 'evidence-based parenting program'? A PRISMA systematic review and meta-analysis of Triple P Philip Wilson, Robert Rush, Susan Hussey, Christine Puckering, Fiona Sim, Clare S Allely, Paul Doku, Alex McConnachie, Christopher Gillberg BMC Medicine 2012, 10:130 (2 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A systematic review and meta-analysis on the outcomes of the Triple P positive parenting programme, indicates long-term effectiveness has not been adequately assessed, and highlights a thorough review of the system is needed before further implementation of the programme is approved.
		Research article Perinatal nicotine exposure induces asthma in second generation offspring Virender K Rehan, Jie Liu, Erum Naeem, Jia Tian, Reiko Sakurai, Kenny Kwong, Omid Akbari, John S Torday BMC Medicine 2012, 10:129 (30 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Smoking during pregnancy induces asthma in offspring, and the effects are permanently transmitted to subsequent generations via epigenetic changes in germ cells, providing a breakthrough in studying transgenerational effects of toxins.
		Research article Prevalence and incidence density rates of chronic comorbidity in type 2 diabetes patients: an exploratory cohort study Hilde Luijks, Tjard Schermer, Hans Bor, Chris van Weel, Toine Lagro-Janssen, Marion Biermans, Wim de Grauw BMC Medicine 2012, 10:128 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comorbidities such as cardiovascular, musculoskeletal and mental diseases are common among those suffering from type 2 diabetes and could interfere with disease management, so diabetes guidelines should take these comorbidities into account.
		Opinion Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals Maciej J Lazarczyk, Patrick R Hof, Constantin Bouras, Panteleimon Giannakopoulos BMC Medicine 2012, 10:127 (25 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Giannakopoulos and colleagues review the latest advances in biomarker discovery for diagnosis of preclinical Alzheimer's disease (AD), but caution against an assumption of AD development, as some subjects who test positive for the biomarkers may never go on to develop AD-related dementia.
		Commentary Health surveillance of deployed military personnel occasionally leads to unexpected findings Alexander C McFarlane BMC Medicine 2012, 10:126 (24 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alexander McFarlane discusses the need for military personnel with serious medical illness to receive equal psychiatric monitoring as those who suffer from combat injuries, as a recent study shows that both groups have a similar risk of developing post-traumatic stress disorder.
		Research article Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis Xuefeng B Ling, Claudia Macaubas, Heather C Alexander, Qiaojun Wen, Edward Chen, Sihua Peng, Yue Sun, Chetan Deshpande, Kuang-Hung Pan, Richard Lin, Chih-Jian Lih, Sheng-Yung P Chang, Tzielan Lee, Christy Sandborg, Ann B Begovich, Stanley N Cohen, Elizabeth D Mellins BMC Medicine 2012, 10:125 (23 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genes related to inflammation are differentially expressed in systemic and polyarticular juvenile idiopathic arthritis, suggesting that distinct immunobiology underlies their clinical phenotypes, which may aid in finding disease-tailored therapy.
		Research article Anatomy of open access publishing: a study of longitudinal development and internal structure Mikael Laakso, Bo-Christer Björk BMC Medicine 2012, 10:124 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The landscape of scientific publishing has changed during the last decade due to steady growth of open access (OA) journals, as the volume of scientific articles published between 2000-2011 in full immediate OA journals has grown rapidly in relative annual share of published journal articles.
		Research article Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies Steven Moylan, Felice N Jacka, Julie A Pasco, Michael Berk BMC Medicine 2012, 10:123 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review shows that smoking and nicotine dependence increase an individual?s risk of panic disorder and generalized anxiety disorder, but inconsistent evidence exists on whether increased anxiety is associated with these behaviors.
		Research article Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation Pedro Bullon, Mario Cordero, José Quiles, Maria Ramirez-Tortosa, Adrian Gonzalez-Alonso, Simona Alfonsi, Rocio García-Marín, Manuel de Miguel, Maurizio Battino BMC Medicine 2012, 10:122 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with periodontitis exhibit reactive oxidation species mediated autophagy, suggesting that autophagy may play a key role in the progression of inflammatory diseases.
		Commentary Making mobility-related disability better: a complex response to a complex problem Kenneth Rockwood BMC Medicine 2012, 10:121 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mobility-related disability in frail older people has been found to be reduced in a recent clinical trial; Kenneth Rockwood comments on understanding the complex needs of these individuals to provide effective treatment and a better quality of life.
		Research article Effect of a multifactorial interdisciplinary intervention on mobility-related disability in frail older people: randomised controlled trial Nicola Fairhall, Catherine Sherrington, Susan E Kurrle, Stephen R Lord, Keri Lockwood, Ian D Cameron BMC Medicine 2012, 10:120 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Frail elderly participants on a 12-month multifactorial interdisciplinary program experience reduced mobility-related disability at both the participation and activity levels, and can therefore be more independent than those who receive only usual care.
		Research article Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis Wei Bao, Ying Rong, Shuang Rong, Liegang Liu BMC Medicine 2012, 10:119 (10 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review and meta-analysis finds increased body iron stores and higher heme iron intake are linked to a higher risk of type 2 diabetes, while non-heme iron intake is not, suggesting that caution needs to be applied in the type and amount of iron supplementation.
		Commentary Toward unbiased assessment of treatment and prevention: modeling household transmission of pandemic influenza Gerardo Chowell, Hiroshi Nishiura BMC Medicine 2012, 10:118 (9 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Accounting for high household variability in a new mathematical model better predicts influenza spread; Gerardo Chowell and Hiroshi Nishiura discuss how unbiased modeling can lead to improved design and delivery of the interventions needed to control an outbreak.
		Research article Estimation of outbreak severity and transmissibility: Influenza A(H1N1)pdm09 in households Thomas House, Nadia Inglis, Joshua V Ross, Fay Wilson, Shakeel Suleman, Obaghe Edeghere, Gillian Smith, Babatunde Olowokure, Matt J Keeling BMC Medicine 2012, 10:117 (9 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new mathematical model to estimate influenza spread accounts for high variability in outcomes by assessing differences in household size and transmissibility rates, therefore providing more comprehensive information to public health policy makers.
		Minireview Personalized medicine in multiple sclerosis: hope or reality? Tobias Derfuss BMC Medicine 2012, 10:116 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tobias Derfuss reviews the progress made in biomarker discovery for multiple sclerosis and discusses how this can help develop a more personalized approach towards treatment of this highly heterogeneous disease.
		Minireview ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients? Christie M Lee, Eddy Fan BMC Medicine 2012, 10:115 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intensive care unit-acquired weakness (ICUAW) is a problem for critical care patients and is exacerbated by barriers against rehabilitation; Eddy Fan and Christie Lee discuss the risk factors for ICUAW, as well as the benefits of early mobility.
		Commentary Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication Eric J Arts BMC Medicine 2012, 10:114 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eric Arts comments on the findings of a recent study which can have major implications on the treatment strategy for newly infected HIV patients carrying highly virulent strains of the virus.
		Review Stroke genetics: prospects for personalized medicine Hugh S Markus BMC Medicine 2012, 10:113 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hugh Markus reviews the latest developments in stroke genetics, highlighting how the variants identified confer only a small risk of disease, and describes how pharmacogenomic approaches can be applied for patient-tailored therapy.
		Review Renal cancer biomarkers: the promise of personalized care Naveen S Vasudev, Peter J Selby, Rosamonde E Banks BMC Medicine 2012, 10:112 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rosamonde Banks and colleagues review recent advances in the genetics and epigenetics of renal cell carcinoma, and discuss how personalized care is being developed through the characterization of biomarkers in the clinic.
		Commentary Is diagnosis enough to guide interventions in mental health? Using case formulation in clinical practice Craig A Macneil, Melissa K Hasty, Philippe Conus, Michael Berk BMC Medicine 2012, 10:111 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Craig Macneil and colleagues comment on the need for clinicians to take a personalized approach when treating patients with mental health disorders, so that the most appropriate intervention can be selected for patients by taking their individual factors into account.
		Commentary Individual differences and evidence-based psychopharmacology RH Belmaker, Yuly Bersudsky, Galila Agam BMC Medicine 2012, 10:110 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Robert Belmaker and colleagues comment on the importance of understanding individual differences for effective drug treatment of psychiatric disorders, and emphasize that patient heterogeneity should be reported in randomised clinical trials.
		Commentary The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention Giovanni Lughezzani BMC Medicine 2012, 10:109 (25 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Obese patients with prostate cancer have altered gene expression in periprostatic adipose tissue compared to patients who are lean; Giovanni Lughezzani comments on this, suggesting that the resultant change in microenvironment may influence cancer progression.
		Research article Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue Ricardo Ribeiro, Cátia Monteiro, Victoria Catalán, Pingzhao Hu, Virgínia Cunha, Amaia Rodríguez, Javier Gómez-Ambrosi, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vitor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Carlos Lopes, Rui Medeiros, Gema Frühbeck BMC Medicine 2012, 10:108 (25 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Obese patients with prostate cancer (PC) have different gene expression in their periprostatic adipose tissue compared to lean patients, which promotes a favorable environment for tumor progression by crosstalk between this tissue and the cancer cells.
		Minireview Epilepsy care guidelines for low- and middle- income countries: From WHO mental health GAP to national programs Juri Katchanov, Gretchen L Birbeck BMC Medicine 2012, 10:107 (24 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Juri Katchanov and Gretchen Birbeck discuss the differing needs of low- and middle-income countries for epilepsy care guidelines compared with higher income countries, and describe how successful execution requires local adaptation.