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		Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
		Research article Income and patient-reported outcomes (PROs) after primary total knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:62 (6 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with a lower income have better pain outcomes and improvement in function after total knee arthroplasty (TKA) than those with a higher income, a finding that needs further research to understand the underlying mechanisms behind this link.
		Research article Summative assessments are more powerful drivers of student learning than resource intensive teaching formats Tobias Raupach, Jamie Brown, Sven Anders, Gerd Hasenfuss, Sigrid Harendza BMC Medicine 2013, 11:61 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Summative assessment of electrocardiogram interpretation in medical students is associated with better examination performance compared with more intense teaching methods, indicating the value of summative assessment in medical education.
		Research article Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Tao Xu, Christina Holzapfel, Xiao Dong, Erik Bader, Zhonghao Yu, Cornelia Prehn, Katrin Perstorfer, Marta Jaremek, Werner Roemisch-Margl, Wolfgang Rathmann, Yixue Li, H -Erich Wichmann, Henri Wallaschofski, Karl H Ladwig, Fabian Theis, Karsten Suhre, Jerzy Adamski, Thomas Illig, Annette Peters, Rui Wang-Sattler BMC Medicine 2013, 11:60 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum metabolite profiles differ between smokers and non-smokers, and these changes are reversible after stopping smoking, suggesting the metabolites could be used as biomarkers to measure success of cessation interventions and evaluate disease risk.
		Research article Worse prognosis of KRAS c.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) Gemma Bruera, Katia Cannita, Daniela Di Giacomo, Aude Lamy, Thierry Frébourg, Jean Christophe Sabourin, Mario Tosi, Edoardo Alesse, Corrado Ficorella, Enrico Ricevuto BMC Medicine 2013, 11:59 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The KRAS mutation in codon 12 (G12D) is associated with poorer survival of metastatic colorectal cancer patients treated with intensive triplet chemotherapy plus bevacizumab compared with patients having wild type or different KRAS genotypes.
		Commentary Do statins lower testosterone and does it matter? Allan D Sniderman, George Thanassoulis BMC Medicine 2013, 11:58 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Allan Sniderman and George Thanassoulis comment on a meta-analysis showing reduction of testosterone by statins, but argue that range of changes rather than average changes need to be considered when measuring the effects of specific drugs.
		Research article The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials C Mary Schooling, Shiu Au Yeung, Guy Freeman, Benjamin J Cowling BMC Medicine 2013, 11:57 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary According to a meta-analysis, treatment with statins, a drug commonly prescribed to patients at risk of cardiovascular disease, can reduce testosterone levels in both men and women, although the cause for this needs to be determined by further studies.
		Commentary Maternal plasma sequencing: a powerful tool towards fetal whole genome recovery Elisavet A Papageorgiou, Philippos C Patsalis BMC Medicine 2013, 11:56 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elisavet Papageorgiou and Philippos Patsalis comment on a novel noninvasive method of fetal haplotype and phenotype analysis, and discuss how this study, published in Genome Medicine, can lead to better prenatal diagnosis of fetal abnormalities.
		Commentary Neural connectivity abnormalities in autism: Insights from the tuberous sclerosis model Charlotte Tye, Patrick Bolton BMC Medicine 2013, 11:55 (27 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Charlotte Tye and Patrick Bolton comment on a study showing that neural networks differ in tuberous sclerosis patients with and without autism spectrum disorder (ASD), and describe how the results support the theory of altered neural circuitry in ASD.
		Research article Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity Jurriaan M Peters, Maxime Taquet, Clemente Vega, Shafali S Jeste, Iván Fernández, Jacqueline Tan, Charles A Nelson, Mustafa Sahin, Simon K Warfield BMC Medicine 2013, 11:54 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Graph theory measurements in autistic patients with and without tuberous sclerosis complex reveal more short-range neural connections compared with non-autistic controls, offering mechanistic insight into the neurobiological mechanisms of autism.
		Commentary Fascin-1 is a novel biomarker of aggressiveness in some carcinomas Vathany Kulasingam, Eleftherios P Diamandis BMC Medicine 2013, 11:53 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vathany Kulasingam and Eleftherios Diamandis comment on a meta-analysis reporting that fascin-1 is associated with cancer mortality and metastasis, and discuss why further research is required before this protein can be used as a biomarker.
		Research article Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis Vanessa Y Tan, Sarah J Lewis, Josephine C Adams, Richard M Martin BMC Medicine 2013, 11:52 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows that fascin-1 is associated with risk of metastasis and mortality in several cancer types, suggesting that it could be developed as a clinical biomarker or therapeutic target for cancer.
		Commentary New guidelines for the initial management of head injury Carolyn M Benson, G Bryan Young BMC Medicine 2013, 11:51 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carolyn Benson and Bryan Young comment on the updated Scandinavian guidelines for initial treatment of head injury, but note that some recommendations cannot be implemented in clinical settings with limited access to specific screening facilities.
		Guideline Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update Johan Undén, Tor Ingebrigtsen, Bertil Romner, the Scandinavian Neurotrauma Committee (SNC) BMC Medicine 2013, 11:50 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Scandinavian Neurotrauma Committee presents an evidence and consensus-based update of guidelines for the initial management of minimal, mild and moderate head injuries in adults, but highlight that the recommendations also need to be validated in non-Scandinavaian clinical settings.
		Commentary Geriatric consultation services - are wards more effective than teams? Ian D Cameron, Susan Kurrle BMC Medicine 2013, 11:49 (22 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Although comprehensive geriatric assessment (CGA) by mobile teams can improve outcomes for mortality in frail older patients, Ian Cameron & Susan Kurrle argue that ward-based CGA is more effective for streaming patients that need complex treatment.
		Research article Impact of geriatric consultation teams on clinical outcome in acute hospitals: a systematic review and meta-analysis Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen, Koen Milisen BMC Medicine 2013, 11:48 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary According to a meta-analysis, comprehensive geriatric assessment (CGA) by mobile teams improves patient mortality rate, but has limited impact on functional status and length of hospital stay, so further research is needed to understand which patients should be targeted.
		Research article Combined impact of traditional and non-traditional health behaviors on mortality: a national prospective cohort study in Spanish older adults David Martínez-Gómez, Pilar Guallar-Castillón, Luz M León-Muñoz, Esther López-García, Fernando Rodríguez-Artalejo BMC Medicine 2013, 11:47 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adherence to non-traditional health behaviors such as interacting with friends, as well as not smoking and eating healthily, could reduce mortality risk in older adults, highlighting the importance of combining these factors for a healthy lifestyle.
		Research article Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study Mora Murri, Isabel Leiva, Juan Miguel Gomez-Zumaquero, Francisco J Tinahones, Fernando Cardona, Federico Soriguer, María Isabel Queipo-Ortuño BMC Medicine 2013, 11:46 (21 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gut microbiota are present at lower quantity and have different composition in children with type 1 diabetes compared with healthy children, possibly due to altered gut permeability, and modification of these bacteria could control diabetes development.
		Research article Shifting from glucose diagnosis to the new HbA1c diagnosis reduces the capability of the Finnish Diabetes Risk Score (FINDRISC) to screen for glucose abnormalities within a real-life primary healthcare preventive strategy Bernardo Costa, Francisco Barrio, Josep L Piñol, Joan J Cabré, Xavier Mundet, Ramon Sagarra, Jordi Salas-Salvadó, Oriol Solà-Morales, the DE-PLAN-CAT/PREDICE Research Group BMC Medicine 2013, 11:45 (21 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The predictive ability of a screening tool for diabetes is reduced when the proposed new hemoglobin-based criteria are used for diagnosis instead of glucose, suggesting that glucose should be measured to assess diabetes risk using this score.
		Research article High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study Flavia Prodam, Roberta Ricotti, Valentina Agarla, Silvia Parlamento, Giulia Genoni, Caterina Balossini, Gillian Walker, Gianluca Aimaretti, Gianni Bona, Simonetta Bellone BMC Medicine 2013, 11:44 (20 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary High levels of adrenocorticotropic hormone and cortisol are associated with distinct cardiovascular disease (CVD) risk factors in obese children, suggesting complex mechanisms underlie interactions between hormones and metabolic impairments in obesity.
		Research article Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List BMC Medicine 2013, 11:43 (20 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In a 102 week trial, addition of dapagliflozin to metformin therapy for type 2 diabetes patients was effective for glycemic control in those who are inadequately controlled by metformin alone, suggesting a novel therapeutic option for those requiring long-term management.
		Research article Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsæter BMC Medicine 2013, 11:42 (19 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caffeine intake from various sources during pregnancy is associated with increased risk of the baby being small for gestational age and decreased birth weight, which may have implications for the recommended consumption of caffeine.
		Opinion Tackling overweight and obesity: does the public health message match the science? Katherine Hafekost, David Lawrence, Francis Mitrou, Therese A O'Sullivan, Stephen R Zubrick BMC Medicine 2013, 11:41 (18 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many weight-loss interventions based on a simple model of energy balance fail to achieve long-term results; Stephen R Zubrick and colleagues recommend that multiple factors affecting energy regulation should be considered in order to tackle obesity.
		Commentary Evidence-based medicine and values-based medicine: partners in clinical education as well as in clinical practice Ed Peile BMC Medicine 2013, 11:40 (15 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Linking values-based and evidence-based medicine in an education strategy promotes better practice; Ed Peile discusses the importance of this for decision processes, highlighting the influence of well designed education strategies.
		Research article Promoting networks between evidence-based medicine and values-based medicine in continuing medical education Myriam M Altamirano-Bustamante, Nelly F Altamirano-Bustamante, Alberto Lifshitz, Ignacio Mora-Magaña, Adalberto de Hoyos, María Ávila-Osorio, Silvia Quintana-Vargas, Jorge A Aguirre, Jorge Méndez, Chiharu Murata, Rodrigo Nava-Diosdado, Oscar Martínez-González, Elisa Calleja, Raúl Vargas, Juan Mejía-Arangure, Araceli Cortez-Domínguez, Fernand Vedrenne-Gutiérrez, Perla Sueiras, Juan Garduño, Sergio Islas-Andrade, Fabio Salamanca, Jesús Kumate-Rodríguez, Alejandro Reyes-Fuentes BMC Medicine 2013, 11:39 (15 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A Continuing Medical Education intervention, aimed at strengthening links between evidence-based and values-based medicine in healthcare personnel, improves high-order values such as openness to change, which are essential for improving medical care.

	All
		Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
		Research article Income and patient-reported outcomes (PROs) after primary total knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:62 (6 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with a lower income have better pain outcomes and improvement in function after total knee arthroplasty (TKA) than those with a higher income, a finding that needs further research to understand the underlying mechanisms behind this link.
		Research article Summative assessments are more powerful drivers of student learning than resource intensive teaching formats Tobias Raupach, Jamie Brown, Sven Anders, Gerd Hasenfuss, Sigrid Harendza BMC Medicine 2013, 11:61 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Summative assessment of electrocardiogram interpretation in medical students is associated with better examination performance compared with more intense teaching methods, indicating the value of summative assessment in medical education.
		Research article Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Tao Xu, Christina Holzapfel, Xiao Dong, Erik Bader, Zhonghao Yu, Cornelia Prehn, Katrin Perstorfer, Marta Jaremek, Werner Roemisch-Margl, Wolfgang Rathmann, Yixue Li, H -Erich Wichmann, Henri Wallaschofski, Karl H Ladwig, Fabian Theis, Karsten Suhre, Jerzy Adamski, Thomas Illig, Annette Peters, Rui Wang-Sattler BMC Medicine 2013, 11:60 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum metabolite profiles differ between smokers and non-smokers, and these changes are reversible after stopping smoking, suggesting the metabolites could be used as biomarkers to measure success of cessation interventions and evaluate disease risk.
		Research article Worse prognosis of KRAS c.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) Gemma Bruera, Katia Cannita, Daniela Di Giacomo, Aude Lamy, Thierry Frébourg, Jean Christophe Sabourin, Mario Tosi, Edoardo Alesse, Corrado Ficorella, Enrico Ricevuto BMC Medicine 2013, 11:59 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The KRAS mutation in codon 12 (G12D) is associated with poorer survival of metastatic colorectal cancer patients treated with intensive triplet chemotherapy plus bevacizumab compared with patients having wild type or different KRAS genotypes.
		Commentary Do statins lower testosterone and does it matter? Allan D Sniderman, George Thanassoulis BMC Medicine 2013, 11:58 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Allan Sniderman and George Thanassoulis comment on a meta-analysis showing reduction of testosterone by statins, but argue that range of changes rather than average changes need to be considered when measuring the effects of specific drugs.
		Research article The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials C Mary Schooling, Shiu Au Yeung, Guy Freeman, Benjamin J Cowling BMC Medicine 2013, 11:57 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary According to a meta-analysis, treatment with statins, a drug commonly prescribed to patients at risk of cardiovascular disease, can reduce testosterone levels in both men and women, although the cause for this needs to be determined by further studies.
		Commentary Maternal plasma sequencing: a powerful tool towards fetal whole genome recovery Elisavet A Papageorgiou, Philippos C Patsalis BMC Medicine 2013, 11:56 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elisavet Papageorgiou and Philippos Patsalis comment on a novel noninvasive method of fetal haplotype and phenotype analysis, and discuss how this study, published in Genome Medicine, can lead to better prenatal diagnosis of fetal abnormalities.
		Commentary Neural connectivity abnormalities in autism: Insights from the tuberous sclerosis model Charlotte Tye, Patrick Bolton BMC Medicine 2013, 11:55 (27 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Charlotte Tye and Patrick Bolton comment on a study showing that neural networks differ in tuberous sclerosis patients with and without autism spectrum disorder (ASD), and describe how the results support the theory of altered neural circuitry in ASD.
		Research article Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity Jurriaan M Peters, Maxime Taquet, Clemente Vega, Shafali S Jeste, Iván Fernández, Jacqueline Tan, Charles A Nelson, Mustafa Sahin, Simon K Warfield BMC Medicine 2013, 11:54 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Graph theory measurements in autistic patients with and without tuberous sclerosis complex reveal more short-range neural connections compared with non-autistic controls, offering mechanistic insight into the neurobiological mechanisms of autism.
		Commentary Fascin-1 is a novel biomarker of aggressiveness in some carcinomas Vathany Kulasingam, Eleftherios P Diamandis BMC Medicine 2013, 11:53 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vathany Kulasingam and Eleftherios Diamandis comment on a meta-analysis reporting that fascin-1 is associated with cancer mortality and metastasis, and discuss why further research is required before this protein can be used as a biomarker.
		Research article Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis Vanessa Y Tan, Sarah J Lewis, Josephine C Adams, Richard M Martin BMC Medicine 2013, 11:52 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows that fascin-1 is associated with risk of metastasis and mortality in several cancer types, suggesting that it could be developed as a clinical biomarker or therapeutic target for cancer.
		Commentary New guidelines for the initial management of head injury Carolyn M Benson, G Bryan Young BMC Medicine 2013, 11:51 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carolyn Benson and Bryan Young comment on the updated Scandinavian guidelines for initial treatment of head injury, but note that some recommendations cannot be implemented in clinical settings with limited access to specific screening facilities.
		Guideline Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update Johan Undén, Tor Ingebrigtsen, Bertil Romner, the Scandinavian Neurotrauma Committee (SNC) BMC Medicine 2013, 11:50 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Scandinavian Neurotrauma Committee presents an evidence and consensus-based update of guidelines for the initial management of minimal, mild and moderate head injuries in adults, but highlight that the recommendations also need to be validated in non-Scandinavaian clinical settings.
		Commentary Geriatric consultation services - are wards more effective than teams? Ian D Cameron, Susan Kurrle BMC Medicine 2013, 11:49 (22 February 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Although comprehensive geriatric assessment (CGA) by mobile teams can improve outcomes for mortality in frail older patients, Ian Cameron & Susan Kurrle argue that ward-based CGA is more effective for streaming patients that need complex treatment.
		Research article Impact of geriatric consultation teams on clinical outcome in acute hospitals: a systematic review and meta-analysis Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen, Koen Milisen BMC Medicine 2013, 11:48 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary According to a meta-analysis, comprehensive geriatric assessment (CGA) by mobile teams improves patient mortality rate, but has limited impact on functional status and length of hospital stay, so further research is needed to understand which patients should be targeted.
		Research article Combined impact of traditional and non-traditional health behaviors on mortality: a national prospective cohort study in Spanish older adults David Martínez-Gómez, Pilar Guallar-Castillón, Luz M León-Muñoz, Esther López-García, Fernando Rodríguez-Artalejo BMC Medicine 2013, 11:47 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adherence to non-traditional health behaviors such as interacting with friends, as well as not smoking and eating healthily, could reduce mortality risk in older adults, highlighting the importance of combining these factors for a healthy lifestyle.
		Research article Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study Mora Murri, Isabel Leiva, Juan Miguel Gomez-Zumaquero, Francisco J Tinahones, Fernando Cardona, Federico Soriguer, María Isabel Queipo-Ortuño BMC Medicine 2013, 11:46 (21 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gut microbiota are present at lower quantity and have different composition in children with type 1 diabetes compared with healthy children, possibly due to altered gut permeability, and modification of these bacteria could control diabetes development.
		Research article Shifting from glucose diagnosis to the new HbA1c diagnosis reduces the capability of the Finnish Diabetes Risk Score (FINDRISC) to screen for glucose abnormalities within a real-life primary healthcare preventive strategy Bernardo Costa, Francisco Barrio, Josep L Piñol, Joan J Cabré, Xavier Mundet, Ramon Sagarra, Jordi Salas-Salvadó, Oriol Solà-Morales, the DE-PLAN-CAT/PREDICE Research Group BMC Medicine 2013, 11:45 (21 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The predictive ability of a screening tool for diabetes is reduced when the proposed new hemoglobin-based criteria are used for diagnosis instead of glucose, suggesting that glucose should be measured to assess diabetes risk using this score.
		Research article High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study Flavia Prodam, Roberta Ricotti, Valentina Agarla, Silvia Parlamento, Giulia Genoni, Caterina Balossini, Gillian Walker, Gianluca Aimaretti, Gianni Bona, Simonetta Bellone BMC Medicine 2013, 11:44 (20 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary High levels of adrenocorticotropic hormone and cortisol are associated with distinct cardiovascular disease (CVD) risk factors in obese children, suggesting complex mechanisms underlie interactions between hormones and metabolic impairments in obesity.
		Research article Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List BMC Medicine 2013, 11:43 (20 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In a 102 week trial, addition of dapagliflozin to metformin therapy for type 2 diabetes patients was effective for glycemic control in those who are inadequately controlled by metformin alone, suggesting a novel therapeutic option for those requiring long-term management.
		Research article Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsæter BMC Medicine 2013, 11:42 (19 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caffeine intake from various sources during pregnancy is associated with increased risk of the baby being small for gestational age and decreased birth weight, which may have implications for the recommended consumption of caffeine.
		Opinion Tackling overweight and obesity: does the public health message match the science? Katherine Hafekost, David Lawrence, Francis Mitrou, Therese A O'Sullivan, Stephen R Zubrick BMC Medicine 2013, 11:41 (18 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many weight-loss interventions based on a simple model of energy balance fail to achieve long-term results; Stephen R Zubrick and colleagues recommend that multiple factors affecting energy regulation should be considered in order to tackle obesity.
		Commentary Evidence-based medicine and values-based medicine: partners in clinical education as well as in clinical practice Ed Peile BMC Medicine 2013, 11:40 (15 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Linking values-based and evidence-based medicine in an education strategy promotes better practice; Ed Peile discusses the importance of this for decision processes, highlighting the influence of well designed education strategies.
		Research article Promoting networks between evidence-based medicine and values-based medicine in continuing medical education Myriam M Altamirano-Bustamante, Nelly F Altamirano-Bustamante, Alberto Lifshitz, Ignacio Mora-Magaña, Adalberto de Hoyos, María Ávila-Osorio, Silvia Quintana-Vargas, Jorge A Aguirre, Jorge Méndez, Chiharu Murata, Rodrigo Nava-Diosdado, Oscar Martínez-González, Elisa Calleja, Raúl Vargas, Juan Mejía-Arangure, Araceli Cortez-Domínguez, Fernand Vedrenne-Gutiérrez, Perla Sueiras, Juan Garduño, Sergio Islas-Andrade, Fabio Salamanca, Jesús Kumate-Rodríguez, Alejandro Reyes-Fuentes BMC Medicine 2013, 11:39 (15 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A Continuing Medical Education intervention, aimed at strengthening links between evidence-based and values-based medicine in healthcare personnel, improves high-order values such as openness to change, which are essential for improving medical care.