BMC Medicine | All articles

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Medicine

Advertisement

Articles

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
		Research article Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis Spyridon Arampatzis, Georg-Christian Funk, Alexander Leichtle, Georg-Martin Fiedler, Christoph Schwarz, Heinz Zimmermann, Aristomenis Exadaktylos, Gregor Lindner BMC Medicine 2013, 11:83 (27 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients on diuretics have a high prevalence of electrolyte disorders on admission to the emergency room and diuretic therapy is associated with in-hospital mortality, suggesting alternative treatment could be considered for at-risk patients.
		Commentary Potential repurposing of oncology drugs for the treatment of Alzheimer's disease Wataru Araki BMC Medicine 2013, 11:82 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There are currently no therapies that target the underlying cause of Alzheimer’s disease (AD); Wataru Araki comments on research showing carmustine reduces amyloid plaques in a mouse model, and discusses the potential of oncology drugs for AD treatment.
		Research article Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine Crystal D Hayes, Debleena Dey, Juan Palavicini, Hongjie Wang, Kshitij A Patkar, Dimitriy Minond, Adel Nefzi, Madepalli K Lakshmana BMC Medicine 2013, 11:81 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The oncology drug carmustine reduces beta amyloid generation and plaque burden in a mouse model of Alzheimer’s disease (AD), possibly through interference with intracellular trafficking, indicating the therapeutic potential of carmustine for AD.
		Guideline Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement Don Husereau, Michael Drummond, Stavros Petrou, Chris Carswell, David Moher, Dan Greenberg, Federico Augustovski, Andrew H Briggs, Josephine Mauskopf, Elizabeth Loder, on behalf of the CHEERS Task Force BMC Medicine 2013, 11:80 (25 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Don Husereau et al. present the Consolidated Health Economic Evaluation Reporting Standards (CHEERS), a consolidated and updated version of current guidelines, which aims to provide clear recommendations for the reporting of health economic evaluations; the statement has been published in 10 journals including BMC Medicine and Cost Effectiveness and Resource Allocation.
		Opinion Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, Daniel F Hermens BMC Medicine 2013, 11:79 (22 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is a need for specific therapies for major depression; Ian Hickie and colleagues recommend that sleep-wake cycles and circadian systems should be targets for mood disorders to provide a personalized approach to patient treatment.
		Review Hypersomnia and depressive symptoms: methodological and clinical aspects Yves Dauvilliers, Régis Lopez, Maurice Ohayon, Sophie Bayard BMC Medicine 2013, 11:78 (21 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yves Dauvilliers and colleagues review the quality and breadth of studies linking hypersomnia and depression, and highlight that interventional studies are needed to ascertain if management of sleep disorders can improve mood disorders and vice versa.
		Technical advance Quantifiable diagnosis of muscular dystrophies and neurogenic atrophies through network analysis Aurora Sáez, Eloy Rivas, Adoración Montero-Sánchez, Carmen Paradas, Begoña Acha, Alberto Pascual, Carmen Serrano, Luis M Escudero BMC Medicine 2013, 11:77 (20 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new diagnostic tool based on a network science analysis captures information in muscle biopsies and helps to diagnose muscular dystrophies and neurogenic atrophies, indicating its potential for use in both clinical and pre-clinical settings.
		Opinion Drug-induced dyskinesia in Parkinson's disease. Should success in clinical management be a function of improvement of motor repertoire rather than amplitude of dyskinesia? Jean-Francois Daneault, Benoit Carignan, Abbas F Sadikot, Michel Panisset, Christian Duval BMC Medicine 2013, 11:76 (20 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Dyskinesia is a major complication in the treatment of Parkinson’s Disease; Christian Duval and colleagues propose a new approach to manage the level and type of these motor symptoms and help improve patients’ quality of life
		Research article Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis Nicola Hobbs, Alan Godfrey, Jose Lara, Linda Errington, Thomas D Meyer, Lynn Rochester, Martin White, John C Mathers, Falko F Sniehotta BMC Medicine 2013, 11:75 (19 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary It is important to remain active in retirement to reduce the risk of age-related diseases; evidence from a systematic review and meta-analysis shows interventions improve physical activity in older adults, so could have significant health benefits.
		Opinion Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne ONeil, Christopher G Davey, Livia Sanna, Michael Maes BMC Medicine 2013, 11:74 (18 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.
		Research article How do autoimmune diseases cluster in families? A systematic review and meta-analysis Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga, Juan-Manuel Anaya BMC Medicine 2013, 11:73 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows autoimmune diseases, particularly autoimmune thyroid disease and systemic lupus erythematosus, aggregate in families, indicating that shared genetic factors may be responsible.
		Editorial Medicine for global health: can “simple interventions” improve the worldwide burden of disease? Gretchen Birbeck BMC Medicine 2013, 11:72 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gretchen Birbeck launches our new article collection, Medicine for Global Health, with an editorial, discussing the relevance of medicine in resource-limited settings, highlighting that simple interventions may help to lessen the global burden of disease.
		Question and Answer Q&A - Economic analyses for vaccine introduction decisions in low- and middle- income countries Raymond Hutubessy BMC Medicine 2013, 11:71 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For the launch of our new article collection, Medicine for Global Health, Raymond Hutubessy, a health economist, discusses the importance of economic analyses for vaccine introduction decisions in low- and middle-income countries.
		Question and Answer Q&A - Global challenges of epilepsy management - an interview with Gretchen Birbeck Gretchen Birbeck BMC Medicine 2013, 11:70 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gretchen Birbeck, a neurologist based in southern Africa, answers our questions on the challenges associated with managing epilepsy in resource-limited settings, as part of our new article collection; Medicine for Global Health.
		Question and Answer Ethical considerations in the globalization of medicine – an interview with James Giordano James Giordano BMC Medicine 2013, 11:69 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Neuroscientist and neuroethicist, James Giordano discusses the ethical issues associated with global health research, and highlights the challenges of conducting such research in low- and middle- income countries.
		Research article Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial Kathryn Maitland, Elizabeth C George, Jennifer A Evans, Sarah Kiguli, Peter Olupot-Olupot, Samuel O Akech, Robert O Opoka, Charles Engoru, Richard Nyeko, George Mtove, Hugh Reyburn, Bernadette Brent, Julius Nteziyaremye, Ayub Mpoya, Natalie Prevatt, Cornelius M Dambisya, Daniel Semakula, Ahmed Ddungu, Vicent Okuuny, Ronald Wokulira, Molline Timbwa, Benedict Otii, Michael Levin, Jane Crawley, Abdel G Babiker, Diana M Gibb, for the FEAST trial group BMC Medicine 2013, 11:68 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Children suffering from sepsis in the FEAST trial given fluid boluses exhibited excess mortality; analysis of the data suggests that this was due to cardiovascular collapse, which should prompt a re-evaluation of fluid resuscitation practice.
		Commentary Causes of death after fluid bolus resuscitation: new insights from FEAST John Myburgh, Simon Finfer BMC Medicine 2013, 11:67 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of the FEAST trial explored the mechanisms behind excess mortality in African sepsis patients given fluid boluses; John Myburgh and Simon Finfer discuss the broader relevance of this result for other populations of critically ill patients.
		Research article A bibliometric analysis of childhood immunization research productivity in Africa since the onset of the Expanded Program on Immunization in 1974 Charles S Wiysonge, Olalekan A Uthman, Peter M Ndumbe, Gregory D Hussey BMC Medicine 2013, 11:66 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Since the onset of the Expanded Program on Immunization, vaccine research productivity in Africa has skewed towards those funded privately, with minimal research input from African authors, suggesting a need for better communication between all stakeholders.
		Research article A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial Ian D Cameron, Nicola Fairhall, Colleen Langron, Keri Lockwood, Noeline Monaghan, Christina Aggar, Catherine Sherrington, Stephen R Lord, Susan E Kurrle BMC Medicine 2013, 11:65 (11 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary In a randomized trial, frail older people on a 12-month multifactorial interdisciplinary program show reduced frailty and improved mobility compared with the group on usual care, indicating that the intervention can be used to treat frailty.
		Review A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk, Michael Maes BMC Medicine 2013, 11:64 (8 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Michael Maes and colleagues review the similarities and differences between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior, concluding that the two disorders have shared pathways, but are distinct conditions.
		Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
		Research article Income and patient-reported outcomes (PROs) after primary total knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:62 (6 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with a lower income have better pain outcomes and improvement in function after total knee arthroplasty (TKA) than those with a higher income, a finding that needs further research to understand the underlying mechanisms behind this link.
		Research article Summative assessments are more powerful drivers of student learning than resource intensive teaching formats Tobias Raupach, Jamie Brown, Sven Anders, Gerd Hasenfuss, Sigrid Harendza BMC Medicine 2013, 11:61 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Summative assessment of electrocardiogram interpretation in medical students is associated with better examination performance compared with more intense teaching methods, indicating the value of summative assessment in medical education.
		Research article Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Tao Xu, Christina Holzapfel, Xiao Dong, Erik Bader, Zhonghao Yu, Cornelia Prehn, Katrin Perstorfer, Marta Jaremek, Werner Roemisch-Margl, Wolfgang Rathmann, Yixue Li, H -Erich Wichmann, Henri Wallaschofski, Karl H Ladwig, Fabian Theis, Karsten Suhre, Jerzy Adamski, Thomas Illig, Annette Peters, Rui Wang-Sattler BMC Medicine 2013, 11:60 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum metabolite profiles differ between smokers and non-smokers, and these changes are reversible after stopping smoking, suggesting the metabolites could be used as biomarkers to measure success of cessation interventions and evaluate disease risk.
		Research article Worse prognosis of KRAS c.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) Gemma Bruera, Katia Cannita, Daniela Di Giacomo, Aude Lamy, Thierry Frébourg, Jean Christophe Sabourin, Mario Tosi, Edoardo Alesse, Corrado Ficorella, Enrico Ricevuto BMC Medicine 2013, 11:59 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The KRAS mutation in codon 12 (G12D) is associated with poorer survival of metastatic colorectal cancer patients treated with intensive triplet chemotherapy plus bevacizumab compared with patients having wild type or different KRAS genotypes.

	All
		Research article Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis Spyridon Arampatzis, Georg-Christian Funk, Alexander Leichtle, Georg-Martin Fiedler, Christoph Schwarz, Heinz Zimmermann, Aristomenis Exadaktylos, Gregor Lindner BMC Medicine 2013, 11:83 (27 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients on diuretics have a high prevalence of electrolyte disorders on admission to the emergency room and diuretic therapy is associated with in-hospital mortality, suggesting alternative treatment could be considered for at-risk patients.
		Commentary Potential repurposing of oncology drugs for the treatment of Alzheimer's disease Wataru Araki BMC Medicine 2013, 11:82 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There are currently no therapies that target the underlying cause of Alzheimer’s disease (AD); Wataru Araki comments on research showing carmustine reduces amyloid plaques in a mouse model, and discusses the potential of oncology drugs for AD treatment.
		Research article Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine Crystal D Hayes, Debleena Dey, Juan Palavicini, Hongjie Wang, Kshitij A Patkar, Dimitriy Minond, Adel Nefzi, Madepalli K Lakshmana BMC Medicine 2013, 11:81 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The oncology drug carmustine reduces beta amyloid generation and plaque burden in a mouse model of Alzheimer’s disease (AD), possibly through interference with intracellular trafficking, indicating the therapeutic potential of carmustine for AD.
		Guideline Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement Don Husereau, Michael Drummond, Stavros Petrou, Chris Carswell, David Moher, Dan Greenberg, Federico Augustovski, Andrew H Briggs, Josephine Mauskopf, Elizabeth Loder, on behalf of the CHEERS Task Force BMC Medicine 2013, 11:80 (25 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Don Husereau et al. present the Consolidated Health Economic Evaluation Reporting Standards (CHEERS), a consolidated and updated version of current guidelines, which aims to provide clear recommendations for the reporting of health economic evaluations; the statement has been published in 10 journals including BMC Medicine and Cost Effectiveness and Resource Allocation.
		Opinion Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, Daniel F Hermens BMC Medicine 2013, 11:79 (22 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is a need for specific therapies for major depression; Ian Hickie and colleagues recommend that sleep-wake cycles and circadian systems should be targets for mood disorders to provide a personalized approach to patient treatment.
		Review Hypersomnia and depressive symptoms: methodological and clinical aspects Yves Dauvilliers, Régis Lopez, Maurice Ohayon, Sophie Bayard BMC Medicine 2013, 11:78 (21 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yves Dauvilliers and colleagues review the quality and breadth of studies linking hypersomnia and depression, and highlight that interventional studies are needed to ascertain if management of sleep disorders can improve mood disorders and vice versa.
		Technical advance Quantifiable diagnosis of muscular dystrophies and neurogenic atrophies through network analysis Aurora Sáez, Eloy Rivas, Adoración Montero-Sánchez, Carmen Paradas, Begoña Acha, Alberto Pascual, Carmen Serrano, Luis M Escudero BMC Medicine 2013, 11:77 (20 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new diagnostic tool based on a network science analysis captures information in muscle biopsies and helps to diagnose muscular dystrophies and neurogenic atrophies, indicating its potential for use in both clinical and pre-clinical settings.
		Opinion Drug-induced dyskinesia in Parkinson's disease. Should success in clinical management be a function of improvement of motor repertoire rather than amplitude of dyskinesia? Jean-Francois Daneault, Benoit Carignan, Abbas F Sadikot, Michel Panisset, Christian Duval BMC Medicine 2013, 11:76 (20 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Dyskinesia is a major complication in the treatment of Parkinson’s Disease; Christian Duval and colleagues propose a new approach to manage the level and type of these motor symptoms and help improve patients’ quality of life
		Research article Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis Nicola Hobbs, Alan Godfrey, Jose Lara, Linda Errington, Thomas D Meyer, Lynn Rochester, Martin White, John C Mathers, Falko F Sniehotta BMC Medicine 2013, 11:75 (19 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary It is important to remain active in retirement to reduce the risk of age-related diseases; evidence from a systematic review and meta-analysis shows interventions improve physical activity in older adults, so could have significant health benefits.
		Opinion Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne ONeil, Christopher G Davey, Livia Sanna, Michael Maes BMC Medicine 2013, 11:74 (18 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Michael Berk and colleagues review the potential of aspirin as a therapeutic agent in neurological and psychiatric disorders, based on the role it may play in regulating inflammation, oxidative and nitrosative stress in the brain.
		Research article How do autoimmune diseases cluster in families? A systematic review and meta-analysis Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga, Juan-Manuel Anaya BMC Medicine 2013, 11:73 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a systematic review and meta-analysis shows autoimmune diseases, particularly autoimmune thyroid disease and systemic lupus erythematosus, aggregate in families, indicating that shared genetic factors may be responsible.
		Editorial Medicine for global health: can “simple interventions” improve the worldwide burden of disease? Gretchen Birbeck BMC Medicine 2013, 11:72 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gretchen Birbeck launches our new article collection, Medicine for Global Health, with an editorial, discussing the relevance of medicine in resource-limited settings, highlighting that simple interventions may help to lessen the global burden of disease.
		Question and Answer Q&A - Economic analyses for vaccine introduction decisions in low- and middle- income countries Raymond Hutubessy BMC Medicine 2013, 11:71 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For the launch of our new article collection, Medicine for Global Health, Raymond Hutubessy, a health economist, discusses the importance of economic analyses for vaccine introduction decisions in low- and middle-income countries.
		Question and Answer Q&A - Global challenges of epilepsy management - an interview with Gretchen Birbeck Gretchen Birbeck BMC Medicine 2013, 11:70 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gretchen Birbeck, a neurologist based in southern Africa, answers our questions on the challenges associated with managing epilepsy in resource-limited settings, as part of our new article collection; Medicine for Global Health.
		Question and Answer Ethical considerations in the globalization of medicine – an interview with James Giordano James Giordano BMC Medicine 2013, 11:69 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Neuroscientist and neuroethicist, James Giordano discusses the ethical issues associated with global health research, and highlights the challenges of conducting such research in low- and middle- income countries.
		Research article Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial Kathryn Maitland, Elizabeth C George, Jennifer A Evans, Sarah Kiguli, Peter Olupot-Olupot, Samuel O Akech, Robert O Opoka, Charles Engoru, Richard Nyeko, George Mtove, Hugh Reyburn, Bernadette Brent, Julius Nteziyaremye, Ayub Mpoya, Natalie Prevatt, Cornelius M Dambisya, Daniel Semakula, Ahmed Ddungu, Vicent Okuuny, Ronald Wokulira, Molline Timbwa, Benedict Otii, Michael Levin, Jane Crawley, Abdel G Babiker, Diana M Gibb, for the FEAST trial group BMC Medicine 2013, 11:68 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Children suffering from sepsis in the FEAST trial given fluid boluses exhibited excess mortality; analysis of the data suggests that this was due to cardiovascular collapse, which should prompt a re-evaluation of fluid resuscitation practice.
		Commentary Causes of death after fluid bolus resuscitation: new insights from FEAST John Myburgh, Simon Finfer BMC Medicine 2013, 11:67 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of the FEAST trial explored the mechanisms behind excess mortality in African sepsis patients given fluid boluses; John Myburgh and Simon Finfer discuss the broader relevance of this result for other populations of critically ill patients.
		Research article A bibliometric analysis of childhood immunization research productivity in Africa since the onset of the Expanded Program on Immunization in 1974 Charles S Wiysonge, Olalekan A Uthman, Peter M Ndumbe, Gregory D Hussey BMC Medicine 2013, 11:66 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Since the onset of the Expanded Program on Immunization, vaccine research productivity in Africa has skewed towards those funded privately, with minimal research input from African authors, suggesting a need for better communication between all stakeholders.
		Research article A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial Ian D Cameron, Nicola Fairhall, Colleen Langron, Keri Lockwood, Noeline Monaghan, Christina Aggar, Catherine Sherrington, Stephen R Lord, Susan E Kurrle BMC Medicine 2013, 11:65 (11 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary In a randomized trial, frail older people on a 12-month multifactorial interdisciplinary program show reduced frailty and improved mobility compared with the group on usual care, indicating that the intervention can be used to treat frailty.
		Review A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk, Michael Maes BMC Medicine 2013, 11:64 (8 March 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Michael Maes and colleagues review the similarities and differences between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior, concluding that the two disorders have shared pathways, but are distinct conditions.
		Research article Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.
		Research article Income and patient-reported outcomes (PROs) after primary total knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:62 (6 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients with a lower income have better pain outcomes and improvement in function after total knee arthroplasty (TKA) than those with a higher income, a finding that needs further research to understand the underlying mechanisms behind this link.
		Research article Summative assessments are more powerful drivers of student learning than resource intensive teaching formats Tobias Raupach, Jamie Brown, Sven Anders, Gerd Hasenfuss, Sigrid Harendza BMC Medicine 2013, 11:61 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Summative assessment of electrocardiogram interpretation in medical students is associated with better examination performance compared with more intense teaching methods, indicating the value of summative assessment in medical education.
		Research article Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Tao Xu, Christina Holzapfel, Xiao Dong, Erik Bader, Zhonghao Yu, Cornelia Prehn, Katrin Perstorfer, Marta Jaremek, Werner Roemisch-Margl, Wolfgang Rathmann, Yixue Li, H -Erich Wichmann, Henri Wallaschofski, Karl H Ladwig, Fabian Theis, Karsten Suhre, Jerzy Adamski, Thomas Illig, Annette Peters, Rui Wang-Sattler BMC Medicine 2013, 11:60 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum metabolite profiles differ between smokers and non-smokers, and these changes are reversible after stopping smoking, suggesting the metabolites could be used as biomarkers to measure success of cessation interventions and evaluate disease risk.
		Research article Worse prognosis of KRAS c.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) Gemma Bruera, Katia Cannita, Daniela Di Giacomo, Aude Lamy, Thierry Frébourg, Jean Christophe Sabourin, Mario Tosi, Edoardo Alesse, Corrado Ficorella, Enrico Ricevuto BMC Medicine 2013, 11:59 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The KRAS mutation in codon 12 (G12D) is associated with poorer survival of metastatic colorectal cancer patients treated with intensive triplet chemotherapy plus bevacizumab compared with patients having wild type or different KRAS genotypes.