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		Research article Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models Parul Gupta, Sanjay K Srivastava BMC Medicine 2012, 10:80 (24 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Phenethyl isothiocyanate (PEITC) has anti-tumor activity in HER2-expressing breast cancer cells and enhances the efficacy of doxorubicin, offering a potential new therapy for HER2-positive breast cancer in those resistant to trastuzumab.
		Editorial Advances in sports nutrition, exercise and medicine: Olympic issues, the legacy and beyond Mike Carmont BMC Medicine 2012, 10:79 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Mike Carmont launches our new article collection 'Advances in Sports Nutrition, Exercise and Medicine', with an editorial, discussing how research in this area has consequences for the general public as well as athletes.
		Technical advance The Transeurope Footrace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486km transcontinental ultramarathon Uwe HW Schütz, Arno Schmidt-Trucksäss, Beat Knechtle, Jürgen Machann, Heike Wiedelbach, Martin Ehrhardt, Wolfgang Freund, Stefan Gröninger, Horst Brunner, Ingo Schulze, Hans-Jürgen Brambs, Christian Billich BMC Medicine 2012, 10:78 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Physiological changes in 44 ultramarathon runners over the course of a 4487 km race can be evaluated using a mobile MRI scanner, as well as metabolic and psychological tests, which could can demonstrate the processes occurring at the limits of endurance
		Commentary Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress Grégoire P Millet, Guillaume Y Millet BMC Medicine 2012, 10:77 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gregoire and Guillaume Millet discuss how the findings of a recent study where physiological changes in ultramarathon runners were assessed by a mobile MRI scanner can shed light on how the body adapts to stress.
		Editorial Born to run. Studying the limits of human performance Andrew Murray, Ricardo JS Costa BMC Medicine 2012, 10:76 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ultramarathon runners Andrew Murray and Ricardo Costa discuss how the Schutz et al. study, which presents methods to assess physiological changes during a 4487 km race as part of the TransEurope Footrace Project, has implications for endurance athletes.
		Research article The effectiveness of neuromuscular warm-up strategies, that require no additional equipment, for preventing lower limb injuries during sports participation: a systematic review Katherine Herman, Christian Barton, Peter Malliaras, Dylan Morrissey BMC Medicine 2012, 10:75 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review and meta-analysis finds that simple neuromuscular warm-up techniques involving no additional equipment can reduce lower extremity injury incidence, so should be considered as part of athletic training.
		Editorial Sport and exercise medicine and the Olympic health legacy Garry A Tew, Robert J Copeland, Simon H Till BMC Medicine 2012, 10:74 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Olympic Legacy aims to use the forthcoming Games as a catalyst for promoting a healthier, more active lifestyle; Simon Till and colleagues highlight how specialists can contribute to this change, as well as the barriers that may prevent success
		Research article Open access versus subscription journals: a comparison of scientific impact Bo-Christer Björk, David Solomon BMC Medicine 2012, 10:73 (17 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology \| Editor’s summary The scientific impact of articles published in open access (OA) and subscription journals are similar when journal discipline, location of publisher and age of publication are compared, which is particularly true in medicine and health, where OA journals founded in the last 10 years receive on average as many citations as subscription journals launched during the same time.
		Research article Antiviral activity of Bifidobacterium adolescentis SPM1005-A on human papillomavirus type 16 Min-Kyeong Cha, Do-Kyung Lee, Hyang-Mi An, Si-Won Lee, Seon-Hee Shin, Jeong-Hyun Kwon, Kyung-Jae Kim, Nam-Joo Ha BMC Medicine 2012, 10:72 (12 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A high risk human papillomavirus (HPV) conducts antiviral activity via suppression of specific oncogenes; a finding which can lead to potential applications for prevention of HPV-associated cervical cancer.
		Research article A cluster randomized trial to assess the effect of clinical pathways for patients with stroke: results of the clinical pathways for effective and appropriate care study Massimiliano Panella, Sara Marchisio, Romeo Brambilla, Kris Vanhaecht, Francesco Di Stanislao BMC Medicine 2012, 10:71 (10 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary The Clinical Pathways for Effective and Appropriate Care (CPEAC) trial shows that ischemic stroke patients have lower 7-day mortality, and are more likely to return to daily life, following structured care treatment compared with usual care.
		Commentary Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke Werner Hacke, Caspar Grond-Ginsbach BMC Medicine 2012, 10:70 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hacke and Grond-Ginsbach comment on a recent GWAS identifying a variant in HDAC9 associated with large vessel stroke, and discuss how different variants associated with distinct stroke subtypes could be used as predictors of risk.
		Research article Month of birth, vitamin D and risk of immune-mediated disease: a case control study Giulio Disanto, George Chaplin, Julia M Morahan, Gavin Giovannoni, Elina Hyppönen, George C Ebers, Sreeram V Ramagopalan BMC Medicine 2012, 10:69 (6 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A large study finds a link between month of birth and prevalence of common immune-mediated diseases, which may be mediated by UVB light exposure and vitamin D status during gestation, providing insight for disease prevention strategies.
		Research article Development and description of measurement properties of an instrument to assess treatment burden among patients with multiple chronic conditions Viet-Thi Tran, Victor M Montori, David T Eton, Dan Baruch, Bruno Falissard, Philippe Ravaud BMC Medicine 2012, 10:68 (4 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Treatment Burden Questionnaire (TBQ) can be used to reliably assess the effect of chronic disease treatment on a patient's quality of life, and could aid in the development of more acceptable regimes, improving patient adherence to treatment.
		Opinion Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression Emanuel Severus, Florian Seemüller, Michael Berger, Sandra Dittmann, Michael Obermeier, Andrea Pfennig, Michael Riedel, Sophia Frangou, Hans-Jürgen Möller, Michael Bauer BMC Medicine 2012, 10:67 (2 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In clinical trials for depression, blinded placebo use could influence outcome; Emanuel Severus et al. propose an alternative design whereby patients can choose to receive treatment and are informed of the benefits, in order to improve trial validity.
		Review Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki, Brian Leonard BMC Medicine 2012, 10:66 (29 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Michael Maes and colleagues review the protective role of inflammation in sickness behavior, in contrast to negative symptoms associated with depression, and suggest these shared immuno-inflammatory pathways can explain the phenomenological similarities between the two conditions.
		Research article A systematic review of the effects of residency training on patient outcomes Renée M van der Leeuw, Kiki MJMH Lombarts, Onyebuchi A Arah, Maas Jan Heineman BMC Medicine 2012, 10:65 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review suggests that patient care is safe and of equal quality when delivered by residents compared with experienced doctors, suggesting that training programs are effective when residents are adequately supervised.
		Research article A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls - a large case control study Frank H Duffy, Heidelise Als BMC Medicine 2012, 10:64 (26 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A large scale study assessing electroencephalography (EEG) patterns in children diagnosed with autism and matched controls identifies differences between these groups, which could be used to provide an EEG signature for autism diagnosis.
		Commentary Attention bias modification: the Emperor's new suit? Paul MG Emmelkamp BMC Medicine 2012, 10:63 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent double-blind RCT reports, contrary to previous studies, that internet-delivered attention bias modification training for social anxiety disorder can be limited by delivery of training; here Paul Emmelkamp comments on other factors which can affect the effectiveness of internet-based therapies.
		Research article Coronary collaterals and risk for restenosis after percutaneous coronary interventions: a meta-analysis Pascal Meier, Andreas Indermuehle, Bertram Pitt, Tobias Traupe, Stefano F de Marchi, Tom Crake, Guido Knapp, Alexandra J Lansky, Christian Seiler BMC Medicine 2012, 10:62 (21 June 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary A meta-analysis finds that increased coronary collateral circulation after a heart attack augments the risk of restenosis after percutaneous coronary interventions (PCI), so could be a useful marker in risk stratification.
		Research article Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population James K Ellis, Toby J Athersuch, Laura DK Thomas, Friederike Teichert, Miriam Pérez-Trujillo, Claus Svendsen, David J Spurgeon, Rajinder Singh, Lars Järup, Jacob G Bundy, Hector C Keun BMC Medicine 2012, 10:61 (19 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Metabolic profiling using nuclear magnetic resonance (NMR) spectroscopy can detect biomarkers of cadmium exposure at levels below the threshold for renal damage, so can be used to assess disease risk in people living near sources of pollution.
		Research article Resitting a high-stakes postgraduate medical examination on multiple occasions: nonlinear multilevel modelling of performance in the MRCP(UK) examinations IC McManus, Katarzyna Ludka BMC Medicine 2012, 10:60 (14 June 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Mathematical modeling shows that performance at MRCP(UK) (Membership of the Royal Colleges of Physicians) medical examinations improves with resits until at least the fourth attempt; should the pass mark increase with multiple attempts to allow only candidates who have improved to succeed?
		Commentary A commentary on TREAT: The trial of early aggressive drug therapy in juvenile idiopathic arthritis Eileen Baildam BMC Medicine 2012, 10:59 (13 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eileen Baildam comments on TREAT, a recent trial on early aggressive treatment of polyarticular juvenile idiopathic arthritis (JIA), where Carol Wallace et al. identifies a crucial timeframe to administer therapy for the best chance of achieving clinical inactive state of the disease.
		Research article Prevalence and prognosis of non-specific chest pain among patients hospitalized for suspected acute coronary syndrome - a systematic literature search Vidar Ruddox, Mariann Mathisen, Jan Otterstad BMC Medicine 2012, 10:58 (12 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that patients diagnosed with non-specific chest pain (NSCP) are a varied group and those with coronary heart disease have the worst prognosis, highlighting the need for guidelines for NSCP management.
		Review Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis Sangita Biswas, Stephen H Benedict, Sharon G Lynch, Steven M LeVine BMC Medicine 2012, 10:57 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Treatments for dyspeptic pain, a common side effect of steroid therapy for multiple sclerosis (MS), may have effects on immunopathogenic mechanisms in MS; Steven LeVine and colleagues discuss these and the implications for MS patients.
		Research article Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure Hongcui Cao, Jinfeng Yang, Jiong Yu, Qiaoling Pan, Jianzhou Li, Pengcheng Zhou, Yanyuan Li, Xiaoping Pan, Jun Li, Yingjie Wang, Lanjuan Li BMC Medicine 2012, 10:56 (6 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells isolated from human placenta can differentiate into hepatocytes and are able to alleviate acute liver failure symptoms in a pig model when transplanted via the portal vein, providing a new therapeutic option for liver disease.

	All
		Research article Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models Parul Gupta, Sanjay K Srivastava BMC Medicine 2012, 10:80 (24 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Phenethyl isothiocyanate (PEITC) has anti-tumor activity in HER2-expressing breast cancer cells and enhances the efficacy of doxorubicin, offering a potential new therapy for HER2-positive breast cancer in those resistant to trastuzumab.
		Editorial Advances in sports nutrition, exercise and medicine: Olympic issues, the legacy and beyond Mike Carmont BMC Medicine 2012, 10:79 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Mike Carmont launches our new article collection 'Advances in Sports Nutrition, Exercise and Medicine', with an editorial, discussing how research in this area has consequences for the general public as well as athletes.
		Technical advance The Transeurope Footrace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486km transcontinental ultramarathon Uwe HW Schütz, Arno Schmidt-Trucksäss, Beat Knechtle, Jürgen Machann, Heike Wiedelbach, Martin Ehrhardt, Wolfgang Freund, Stefan Gröninger, Horst Brunner, Ingo Schulze, Hans-Jürgen Brambs, Christian Billich BMC Medicine 2012, 10:78 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Physiological changes in 44 ultramarathon runners over the course of a 4487 km race can be evaluated using a mobile MRI scanner, as well as metabolic and psychological tests, which could can demonstrate the processes occurring at the limits of endurance
		Commentary Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress Grégoire P Millet, Guillaume Y Millet BMC Medicine 2012, 10:77 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gregoire and Guillaume Millet discuss how the findings of a recent study where physiological changes in ultramarathon runners were assessed by a mobile MRI scanner can shed light on how the body adapts to stress.
		Editorial Born to run. Studying the limits of human performance Andrew Murray, Ricardo JS Costa BMC Medicine 2012, 10:76 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ultramarathon runners Andrew Murray and Ricardo Costa discuss how the Schutz et al. study, which presents methods to assess physiological changes during a 4487 km race as part of the TransEurope Footrace Project, has implications for endurance athletes.
		Research article The effectiveness of neuromuscular warm-up strategies, that require no additional equipment, for preventing lower limb injuries during sports participation: a systematic review Katherine Herman, Christian Barton, Peter Malliaras, Dylan Morrissey BMC Medicine 2012, 10:75 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review and meta-analysis finds that simple neuromuscular warm-up techniques involving no additional equipment can reduce lower extremity injury incidence, so should be considered as part of athletic training.
		Editorial Sport and exercise medicine and the Olympic health legacy Garry A Tew, Robert J Copeland, Simon H Till BMC Medicine 2012, 10:74 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Olympic Legacy aims to use the forthcoming Games as a catalyst for promoting a healthier, more active lifestyle; Simon Till and colleagues highlight how specialists can contribute to this change, as well as the barriers that may prevent success
		Research article Open access versus subscription journals: a comparison of scientific impact Bo-Christer Björk, David Solomon BMC Medicine 2012, 10:73 (17 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology \| Editor’s summary The scientific impact of articles published in open access (OA) and subscription journals are similar when journal discipline, location of publisher and age of publication are compared, which is particularly true in medicine and health, where OA journals founded in the last 10 years receive on average as many citations as subscription journals launched during the same time.
		Research article Antiviral activity of Bifidobacterium adolescentis SPM1005-A on human papillomavirus type 16 Min-Kyeong Cha, Do-Kyung Lee, Hyang-Mi An, Si-Won Lee, Seon-Hee Shin, Jeong-Hyun Kwon, Kyung-Jae Kim, Nam-Joo Ha BMC Medicine 2012, 10:72 (12 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A high risk human papillomavirus (HPV) conducts antiviral activity via suppression of specific oncogenes; a finding which can lead to potential applications for prevention of HPV-associated cervical cancer.
		Research article A cluster randomized trial to assess the effect of clinical pathways for patients with stroke: results of the clinical pathways for effective and appropriate care study Massimiliano Panella, Sara Marchisio, Romeo Brambilla, Kris Vanhaecht, Francesco Di Stanislao BMC Medicine 2012, 10:71 (10 July 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary The Clinical Pathways for Effective and Appropriate Care (CPEAC) trial shows that ischemic stroke patients have lower 7-day mortality, and are more likely to return to daily life, following structured care treatment compared with usual care.
		Commentary Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke Werner Hacke, Caspar Grond-Ginsbach BMC Medicine 2012, 10:70 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hacke and Grond-Ginsbach comment on a recent GWAS identifying a variant in HDAC9 associated with large vessel stroke, and discuss how different variants associated with distinct stroke subtypes could be used as predictors of risk.
		Research article Month of birth, vitamin D and risk of immune-mediated disease: a case control study Giulio Disanto, George Chaplin, Julia M Morahan, Gavin Giovannoni, Elina Hyppönen, George C Ebers, Sreeram V Ramagopalan BMC Medicine 2012, 10:69 (6 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A large study finds a link between month of birth and prevalence of common immune-mediated diseases, which may be mediated by UVB light exposure and vitamin D status during gestation, providing insight for disease prevention strategies.
		Research article Development and description of measurement properties of an instrument to assess treatment burden among patients with multiple chronic conditions Viet-Thi Tran, Victor M Montori, David T Eton, Dan Baruch, Bruno Falissard, Philippe Ravaud BMC Medicine 2012, 10:68 (4 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Treatment Burden Questionnaire (TBQ) can be used to reliably assess the effect of chronic disease treatment on a patient's quality of life, and could aid in the development of more acceptable regimes, improving patient adherence to treatment.
		Opinion Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression Emanuel Severus, Florian Seemüller, Michael Berger, Sandra Dittmann, Michael Obermeier, Andrea Pfennig, Michael Riedel, Sophia Frangou, Hans-Jürgen Möller, Michael Bauer BMC Medicine 2012, 10:67 (2 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In clinical trials for depression, blinded placebo use could influence outcome; Emanuel Severus et al. propose an alternative design whereby patients can choose to receive treatment and are informed of the benefits, in order to improve trial validity.
		Review Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki, Brian Leonard BMC Medicine 2012, 10:66 (29 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Michael Maes and colleagues review the protective role of inflammation in sickness behavior, in contrast to negative symptoms associated with depression, and suggest these shared immuno-inflammatory pathways can explain the phenomenological similarities between the two conditions.
		Research article A systematic review of the effects of residency training on patient outcomes Renée M van der Leeuw, Kiki MJMH Lombarts, Onyebuchi A Arah, Maas Jan Heineman BMC Medicine 2012, 10:65 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A systematic review suggests that patient care is safe and of equal quality when delivered by residents compared with experienced doctors, suggesting that training programs are effective when residents are adequately supervised.
		Research article A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls - a large case control study Frank H Duffy, Heidelise Als BMC Medicine 2012, 10:64 (26 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A large scale study assessing electroencephalography (EEG) patterns in children diagnosed with autism and matched controls identifies differences between these groups, which could be used to provide an EEG signature for autism diagnosis.
		Commentary Attention bias modification: the Emperor's new suit? Paul MG Emmelkamp BMC Medicine 2012, 10:63 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent double-blind RCT reports, contrary to previous studies, that internet-delivered attention bias modification training for social anxiety disorder can be limited by delivery of training; here Paul Emmelkamp comments on other factors which can affect the effectiveness of internet-based therapies.
		Research article Coronary collaterals and risk for restenosis after percutaneous coronary interventions: a meta-analysis Pascal Meier, Andreas Indermuehle, Bertram Pitt, Tobias Traupe, Stefano F de Marchi, Tom Crake, Guido Knapp, Alexandra J Lansky, Christian Seiler BMC Medicine 2012, 10:62 (21 June 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary A meta-analysis finds that increased coronary collateral circulation after a heart attack augments the risk of restenosis after percutaneous coronary interventions (PCI), so could be a useful marker in risk stratification.
		Research article Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population James K Ellis, Toby J Athersuch, Laura DK Thomas, Friederike Teichert, Miriam Pérez-Trujillo, Claus Svendsen, David J Spurgeon, Rajinder Singh, Lars Järup, Jacob G Bundy, Hector C Keun BMC Medicine 2012, 10:61 (19 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Metabolic profiling using nuclear magnetic resonance (NMR) spectroscopy can detect biomarkers of cadmium exposure at levels below the threshold for renal damage, so can be used to assess disease risk in people living near sources of pollution.
		Research article Resitting a high-stakes postgraduate medical examination on multiple occasions: nonlinear multilevel modelling of performance in the MRCP(UK) examinations IC McManus, Katarzyna Ludka BMC Medicine 2012, 10:60 (14 June 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Mathematical modeling shows that performance at MRCP(UK) (Membership of the Royal Colleges of Physicians) medical examinations improves with resits until at least the fourth attempt; should the pass mark increase with multiple attempts to allow only candidates who have improved to succeed?
		Commentary A commentary on TREAT: The trial of early aggressive drug therapy in juvenile idiopathic arthritis Eileen Baildam BMC Medicine 2012, 10:59 (13 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eileen Baildam comments on TREAT, a recent trial on early aggressive treatment of polyarticular juvenile idiopathic arthritis (JIA), where Carol Wallace et al. identifies a crucial timeframe to administer therapy for the best chance of achieving clinical inactive state of the disease.
		Research article Prevalence and prognosis of non-specific chest pain among patients hospitalized for suspected acute coronary syndrome - a systematic literature search Vidar Ruddox, Mariann Mathisen, Jan Otterstad BMC Medicine 2012, 10:58 (12 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review suggests that patients diagnosed with non-specific chest pain (NSCP) are a varied group and those with coronary heart disease have the worst prognosis, highlighting the need for guidelines for NSCP management.
		Review Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis Sangita Biswas, Stephen H Benedict, Sharon G Lynch, Steven M LeVine BMC Medicine 2012, 10:57 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Treatments for dyspeptic pain, a common side effect of steroid therapy for multiple sclerosis (MS), may have effects on immunopathogenic mechanisms in MS; Steven LeVine and colleagues discuss these and the implications for MS patients.
		Research article Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure Hongcui Cao, Jinfeng Yang, Jiong Yu, Qiaoling Pan, Jianzhou Li, Pengcheng Zhou, Yanyuan Li, Xiaoping Pan, Jun Li, Yingjie Wang, Lanjuan Li BMC Medicine 2012, 10:56 (6 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells isolated from human placenta can differentiate into hepatocytes and are able to alleviate acute liver failure symptoms in a pig model when transplanted via the portal vein, providing a new therapeutic option for liver disease.