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		Review Special considerations in prognostic research in cancer involving genetic polymorphisms Sevtap Savas, Geoffrey Liu, Wei Xu BMC Medicine 2013, 11:149 (17 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analyzing genetic polymorphisms is important for the development of new cancer biomarkers; Wei Xu and colleagues review special considerations that must be taken into account when studying tumor genetics, and highlight the potential problems.
		Debate When to start antiretroviral therapy: the need for an evidence base during early HIV infection Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges, James D Neaton BMC Medicine 2013, 11:148 (14 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jens Lundgren and colleagues argue for a more cautious approach to starting antiretroviral therapy, highlighting that there is no evidence from randomized trials to suggest the benefits of starting therapy early outweigh the potential harms.
		Debate When to start antiretroviral therapy: as soon as possible Ricardo A Franco, Michael S Saag BMC Medicine 2013, 11:147 (14 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ricardo Franco and Michael Saag discuss the benefits of starting HIV therapy early, arguing that treatment should be given as soon as possible to reduce viral replication, prevent transmission and avoid the problems associated with inflammation.
		Research article Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells Georg Siegel, Torsten Kluba, Ursula Hermanutz-Klein, Karen Bieback, Hinnak Northoff, Richard Schäfer BMC Medicine 2013, 11:146 (11 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Mesenchymal stromal cells have potential for clinical application in regenerative medicine, but have varying functional properties owing to donor age and gender, suggesting that identification of these factors are important for clinical use.
		Minireview Origins of increased airway smooth muscle mass in asthma Rachid Berair, Ruth Saunders, Christopher E Brightling BMC Medicine 2013, 11:145 (6 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Christopher Brightling and colleagues discuss the contribution of different cell types to airway smooth muscle hyperplasia, and describe how a greater understanding of these mechanisms will guide the development of new therapies for asthma.
		Research article Ipsilateral lower extremity joint involvement increases the risk of poor pain and function outcomes after hip or knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:144 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ipsilateral joint involvement is shown to affect pain and function outcomes after total hip or knee arthroplasty, indicating that arthroplasty outcomes may be improved if these issues are addressed.
		Review The collateral circulation of the heart Pascal Meier, Stephan H Schirmer, Alexandra J Lansky, Adam Timmis, Bertram Pitt, Christian Seiler BMC Medicine 2013, 11:143 (4 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Pascal Meier and colleagues discuss the relevance of collateral arteries in the heart, and describe recent evidence indicating these arteries have a protective role in preserving myocardial function in patients with coronary heart disease.
		Review Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis Clive B Beggs BMC Medicine 2013, 11:142 (31 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Neurological disorders, such as multiple sclerosis (MS) and leukoaraiosis have been associated with venous abnormalities that contribute to the pathophysiology; Clive Beggs reviews the evidence for this, concluding that the role of cerebral flow in MS remains unclear.
		Research article Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A systematic review Lizzy M Brewster, Yackoob K Seedat BMC Medicine 2013, 11:141 (30 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review shows pharmacokinetics, plasma renin and genetic polymorphisms are not associated with antihypertensive drug therapy, but African ancestry is the best predictor of individual responses to these drugs.
		Research article Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial Peter Hajek, Katie Smith, Al-Rehan Dhanji, Hayden McRobbie BMC Medicine 2013, 11:140 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In a randomized trial, participants seeking to quit smoking over 12 weeks did not benefit from adding nicotine patch to varenicline, suggesting that although further trials are required, there is no benefit in taking both treatments.
		Research article Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth Carolina Belmar-Lopez, Gracia Mendoza, Daniel Oberg, Jerome Burnet, Carlos Simon, Irene Cervello, Maite Iglesias, Juan Ramirez, Pilar Lopez-Larrubia, Miguel Quintanilla, Pilar Martin-Duque BMC Medicine 2013, 11:139 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs), which could be used as vehicles for anti-cancer agents owing to tumor homing properties, have different migration and recruitment capacities dependent on their lineages, suggesting that clinical characterization to ensure efficacy and safety is vital.
		Commentary Tobacco smoking and depression: time to move on to a new research paradigm in medicine? Peter de Jonge, Elisabeth Bos BMC Medicine 2013, 11:138 (24 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data.
		Research article Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review Nicola A Maffiuletti, Marc Roig, Eleftherios Karatzanos, Serafim Nanas BMC Medicine 2013, 11:137 (23 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Critically ill patients in intensive care are prone to muscle weakness and wasting; a systematic review suggests neuromuscular electrical stimulation therapy is effective in preventing muscle weakness, but is inconclusive for muscle wasting.
		Commentary Processing of meats and cardiovascular risk: time to focus on preservatives Renata Micha, Georgios Michas, Martin Lajous, Dariush Mozaffarian BMC Medicine 2013, 11:136 (23 May 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Dariush Mozaffarian and colleagues comment on a study showing that processed meat is linked to increased mortality risk, and emphasize how health guidance should recommend avoiding processed meat rather than focusing on fat content.
		Research article Cost effectiveness of patient education for the prevention of falls in hospital: economic evaluation from a randomized controlled trial Terry P Haines, Anne-Marie Hill, Keith D Hill, Sandra G Brauer, Tammy Hoffmann, Christopher Etherton-Beer, Steven M McPhail BMC Medicine 2013, 11:135 (22 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Economic analysis of a clinical trial shows that a patient education program to prevent falls in hospitalized elderly people is effective and cost-saving, provided 4% of these patients would otherwise fall under usual care.
		Research article A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack BMC Medicine 2013, 11:134 (21 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alloreactive T cells are present in the blood 2 weeks before the onset of acute graft-versus-host disease (GVHD) symptoms in a mouse model, suggesting these cells could be measured to allow early diagnosis and timely therapeutic intervention.
		Commentary Patient advocacy and DSM-5 Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.
		Review Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.
		Debate Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.
		Debate Depression as a non-causal variable risk marker in coronary heart disease Anna Meijer, Marij Zuidersma, Peter de Jonge BMC Medicine 2013, 11:130 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD.
		Review Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.
		Editorial The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5.
		Debate Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis.
		Debate Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders.
		Debate Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders.
		Review The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment.
		Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
		Research article Characteristics, changes and influence of body composition during a 4486 km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
		Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
		Review Novel therapeutic agents in clinical development for systemic lupus erythematosus Natasha Jordan, Pamela MK Lutalo, David P D’Cruz BMC Medicine 2013, 11:120 (3 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials.
		Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
		Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
		Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
		Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
		Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
		Research article Effects of breastfeeding on body composition and maturational tempo in the rat Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg BMC Medicine 2013, 11:114 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaning from lactation at an early age leads to faster development and leaner, longer bodies in comparison to late-weaned rats, and these effects are transmitted through generations as early-weaned progeny reach sexual maturation at an earlier age.
		Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
		Research article Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten BMC Medicine 2013, 11:112 (26 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary When compared with universal rotavirus (RV) vaccination, targeted vaccination of high-risk children is highly cost-effective in the Netherlands, suggesting that targeted strategies should be used to reduce RV hospitalizations in Europe.
		Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
		Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.
		Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
		Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
		Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
		Research article Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens BMC Medicine 2013, 11:105 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caregivers’ awareness of dementia as a terminal disease is associated with better patient comfort, suggesting that educating the families of dementia sufferers is important to ensure appropriate planning is undertaken to improve the care of these patients.
		Minireview Advances in bladder cancer imaging Shaista Hafeez, Robert Huddart BMC Medicine 2013, 11:104 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shaista Hafeez and Robert Huddart discuss recent advances in bladder cancer imaging and review progress in functional imaging techniques which, upon further development and validation, may lead to tumor mapping and personalized patient therapies.
		Research article ‘You can’t just hit a button’: an ethnographic study of strategies to repurpose data from advanced clinical information systems for clinical process improvement Cecily Morrison, Matthew Jones, Rachel Jones, Alain Vuylsteke BMC Medicine 2013, 11:103 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Clinical information systems (CIS) are used in current healthcare policies to improve clinical processes; new evidence shows that redistribution of extra work, sufficient time, financial support and motivation are needed to deliver CIS efficiently in ICU.
		Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
		Editorial Novel pebbles in the mosaic of autoimmunity Carlo Perricone, Nancy Agmon-Levin, Yehuda Shoenfeld BMC Medicine 2013, 11:101 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yehuda Shoenfeld and colleagues launch our new article collection, Autoimmunity, with an editorial discussing the evolution of autoimmunity research and emerging concepts in the pathology of autoimmune diseases.
		Review Requirements for innate immune pathways in environmentally induced autoimmunity Kenneth Pollard, Dwight H Kono BMC Medicine 2013, 11:100 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Kenneth Pollard and Dwight Kono review the immune pathways involved in idiopathic and environmentally induced autoimmunity, and highlight that further investigation is needed to understand the mechanistic pathways underlying this elusive condition.

	All
		Review Special considerations in prognostic research in cancer involving genetic polymorphisms Sevtap Savas, Geoffrey Liu, Wei Xu BMC Medicine 2013, 11:149 (17 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analyzing genetic polymorphisms is important for the development of new cancer biomarkers; Wei Xu and colleagues review special considerations that must be taken into account when studying tumor genetics, and highlight the potential problems.
		Debate When to start antiretroviral therapy: the need for an evidence base during early HIV infection Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges, James D Neaton BMC Medicine 2013, 11:148 (14 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jens Lundgren and colleagues argue for a more cautious approach to starting antiretroviral therapy, highlighting that there is no evidence from randomized trials to suggest the benefits of starting therapy early outweigh the potential harms.
		Debate When to start antiretroviral therapy: as soon as possible Ricardo A Franco, Michael S Saag BMC Medicine 2013, 11:147 (14 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ricardo Franco and Michael Saag discuss the benefits of starting HIV therapy early, arguing that treatment should be given as soon as possible to reduce viral replication, prevent transmission and avoid the problems associated with inflammation.
		Research article Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells Georg Siegel, Torsten Kluba, Ursula Hermanutz-Klein, Karen Bieback, Hinnak Northoff, Richard Schäfer BMC Medicine 2013, 11:146 (11 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Mesenchymal stromal cells have potential for clinical application in regenerative medicine, but have varying functional properties owing to donor age and gender, suggesting that identification of these factors are important for clinical use.
		Minireview Origins of increased airway smooth muscle mass in asthma Rachid Berair, Ruth Saunders, Christopher E Brightling BMC Medicine 2013, 11:145 (6 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Christopher Brightling and colleagues discuss the contribution of different cell types to airway smooth muscle hyperplasia, and describe how a greater understanding of these mechanisms will guide the development of new therapies for asthma.
		Research article Ipsilateral lower extremity joint involvement increases the risk of poor pain and function outcomes after hip or knee arthroplasty Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:144 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ipsilateral joint involvement is shown to affect pain and function outcomes after total hip or knee arthroplasty, indicating that arthroplasty outcomes may be improved if these issues are addressed.
		Review The collateral circulation of the heart Pascal Meier, Stephan H Schirmer, Alexandra J Lansky, Adam Timmis, Bertram Pitt, Christian Seiler BMC Medicine 2013, 11:143 (4 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Pascal Meier and colleagues discuss the relevance of collateral arteries in the heart, and describe recent evidence indicating these arteries have a protective role in preserving myocardial function in patients with coronary heart disease.
		Review Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis Clive B Beggs BMC Medicine 2013, 11:142 (31 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Neurological disorders, such as multiple sclerosis (MS) and leukoaraiosis have been associated with venous abnormalities that contribute to the pathophysiology; Clive Beggs reviews the evidence for this, concluding that the role of cerebral flow in MS remains unclear.
		Research article Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A systematic review Lizzy M Brewster, Yackoob K Seedat BMC Medicine 2013, 11:141 (30 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review shows pharmacokinetics, plasma renin and genetic polymorphisms are not associated with antihypertensive drug therapy, but African ancestry is the best predictor of individual responses to these drugs.
		Research article Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial Peter Hajek, Katie Smith, Al-Rehan Dhanji, Hayden McRobbie BMC Medicine 2013, 11:140 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In a randomized trial, participants seeking to quit smoking over 12 weeks did not benefit from adding nicotine patch to varenicline, suggesting that although further trials are required, there is no benefit in taking both treatments.
		Research article Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth Carolina Belmar-Lopez, Gracia Mendoza, Daniel Oberg, Jerome Burnet, Carlos Simon, Irene Cervello, Maite Iglesias, Juan Ramirez, Pilar Lopez-Larrubia, Miguel Quintanilla, Pilar Martin-Duque BMC Medicine 2013, 11:139 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs), which could be used as vehicles for anti-cancer agents owing to tumor homing properties, have different migration and recruitment capacities dependent on their lineages, suggesting that clinical characterization to ensure efficacy and safety is vital.
		Commentary Tobacco smoking and depression: time to move on to a new research paradigm in medicine? Peter de Jonge, Elisabeth Bos BMC Medicine 2013, 11:138 (24 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data.
		Research article Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review Nicola A Maffiuletti, Marc Roig, Eleftherios Karatzanos, Serafim Nanas BMC Medicine 2013, 11:137 (23 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Critically ill patients in intensive care are prone to muscle weakness and wasting; a systematic review suggests neuromuscular electrical stimulation therapy is effective in preventing muscle weakness, but is inconclusive for muscle wasting.
		Commentary Processing of meats and cardiovascular risk: time to focus on preservatives Renata Micha, Georgios Michas, Martin Lajous, Dariush Mozaffarian BMC Medicine 2013, 11:136 (23 May 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Dariush Mozaffarian and colleagues comment on a study showing that processed meat is linked to increased mortality risk, and emphasize how health guidance should recommend avoiding processed meat rather than focusing on fat content.
		Research article Cost effectiveness of patient education for the prevention of falls in hospital: economic evaluation from a randomized controlled trial Terry P Haines, Anne-Marie Hill, Keith D Hill, Sandra G Brauer, Tammy Hoffmann, Christopher Etherton-Beer, Steven M McPhail BMC Medicine 2013, 11:135 (22 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Economic analysis of a clinical trial shows that a patient education program to prevent falls in hospitalized elderly people is effective and cost-saving, provided 4% of these patients would otherwise fall under usual care.
		Research article A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack BMC Medicine 2013, 11:134 (21 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alloreactive T cells are present in the blood 2 weeks before the onset of acute graft-versus-host disease (GVHD) symptoms in a mouse model, suggesting these cells could be measured to allow early diagnosis and timely therapeutic intervention.
		Commentary Patient advocacy and DSM-5 Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.
		Review Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.
		Debate Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.
		Debate Depression as a non-causal variable risk marker in coronary heart disease Anna Meijer, Marij Zuidersma, Peter de Jonge BMC Medicine 2013, 11:130 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD.
		Review Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.
		Editorial The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5.
		Debate Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis.
		Debate Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders.
		Debate Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders.
		Review The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment.
		Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
		Research article Characteristics, changes and influence of body composition during a 4486 km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
		Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
		Review Novel therapeutic agents in clinical development for systemic lupus erythematosus Natasha Jordan, Pamela MK Lutalo, David P D’Cruz BMC Medicine 2013, 11:120 (3 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials.
		Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
		Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
		Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
		Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
		Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
		Research article Effects of breastfeeding on body composition and maturational tempo in the rat Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg BMC Medicine 2013, 11:114 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaning from lactation at an early age leads to faster development and leaner, longer bodies in comparison to late-weaned rats, and these effects are transmitted through generations as early-weaned progeny reach sexual maturation at an earlier age.
		Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
		Research article Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten BMC Medicine 2013, 11:112 (26 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary When compared with universal rotavirus (RV) vaccination, targeted vaccination of high-risk children is highly cost-effective in the Netherlands, suggesting that targeted strategies should be used to reduce RV hospitalizations in Europe.
		Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
		Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.
		Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
		Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
		Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
		Research article Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens BMC Medicine 2013, 11:105 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caregivers’ awareness of dementia as a terminal disease is associated with better patient comfort, suggesting that educating the families of dementia sufferers is important to ensure appropriate planning is undertaken to improve the care of these patients.
		Minireview Advances in bladder cancer imaging Shaista Hafeez, Robert Huddart BMC Medicine 2013, 11:104 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shaista Hafeez and Robert Huddart discuss recent advances in bladder cancer imaging and review progress in functional imaging techniques which, upon further development and validation, may lead to tumor mapping and personalized patient therapies.
		Research article ‘You can’t just hit a button’: an ethnographic study of strategies to repurpose data from advanced clinical information systems for clinical process improvement Cecily Morrison, Matthew Jones, Rachel Jones, Alain Vuylsteke BMC Medicine 2013, 11:103 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Clinical information systems (CIS) are used in current healthcare policies to improve clinical processes; new evidence shows that redistribution of extra work, sufficient time, financial support and motivation are needed to deliver CIS efficiently in ICU.
		Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
		Editorial Novel pebbles in the mosaic of autoimmunity Carlo Perricone, Nancy Agmon-Levin, Yehuda Shoenfeld BMC Medicine 2013, 11:101 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yehuda Shoenfeld and colleagues launch our new article collection, Autoimmunity, with an editorial discussing the evolution of autoimmunity research and emerging concepts in the pathology of autoimmune diseases.
		Review Requirements for innate immune pathways in environmentally induced autoimmunity Kenneth Pollard, Dwight H Kono BMC Medicine 2013, 11:100 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Kenneth Pollard and Dwight Kono review the immune pathways involved in idiopathic and environmentally induced autoimmunity, and highlight that further investigation is needed to understand the mechanistic pathways underlying this elusive condition.