Articles
Volume 11 (2013) - May 2013
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Review
Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis Clive B Beggs BMC Medicine 2013, 11:142 (31 May 2013) Neurological disorders, such as multiple sclerosis (MS) and leukoaraiosis have been associated with venous abnormalities that contribute to the pathophysiology; Clive Beggs reviews the evidence for this, concluding that the role of cerebral flow in MS remains unclear. |
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Research article
Lizzy M Brewster, Yackoob K Seedat BMC Medicine 2013, 11:141 (30 May 2013) Evidence from a systematic review shows pharmacokinetics, plasma renin and genetic polymorphisms are not associated with antihypertensive drug therapy, but African ancestry is the best predictor of individual responses to these drugs. |
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Research article
Peter Hajek, Katie Smith, Al-Rehan Dhanji, Hayden McRobbie BMC Medicine 2013, 11:140 (29 May 2013) In a randomized trial, participants seeking to quit smoking over 12 weeks did not benefit from adding nicotine patch to varenicline, suggesting that although further trials are required, there is no benefit in taking both treatments. |
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Research article
Carolina Belmar-Lopez, Gracia Mendoza, Daniel Oberg, Jerome Burnet, Carlos Simon, Irene Cervello, Maite Iglesias, Juan Ramirez, Pilar Lopez-Larrubia, Miguel Quintanilla, Pilar Martin-Duque BMC Medicine 2013, 11:139 (28 May 2013) Mesenchymal stem cells (MSCs), which could be used as vehicles for anti-cancer agents owing to tumor homing properties, have different migration and recruitment capacities dependent on their lineages, suggesting that clinical characterization to ensure efficacy and safety is vital. |
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Commentary
Tobacco smoking and depression: time to move on to a new research paradigm in medicine? Peter de Jonge, Elisabeth Bos BMC Medicine 2013, 11:138 (24 May 2013) Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data. |
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Research article
Nicola A Maffiuletti, Marc Roig, Eleftherios Karatzanos, Serafim Nanas BMC Medicine 2013, 11:137 (23 May 2013) Critically ill patients in intensive care are prone to muscle weakness and wasting; a systematic review suggests neuromuscular electrical stimulation therapy is effective in preventing muscle weakness, but is inconclusive for muscle wasting. |
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Commentary
Processing of meats and cardiovascular risk: time to focus on preservatives Renata Micha, Georgios Michas, Martin Lajous, Dariush Mozaffarian BMC Medicine 2013, 11:136 (23 May 2013) Dariush Mozaffarian and colleagues comment on a study showing that processed meat is linked to increased mortality risk, and emphasize how health guidance should recommend avoiding processed meat rather than focusing on fat content. |
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Research article
Terry P Haines, Anne-Marie Hill, Keith D Hill, Sandra G Brauer, Tammy Hoffmann, Christopher Etherton-Beer, Steven M McPhail BMC Medicine 2013, 11:135 (22 May 2013) Economic analysis of a clinical trial shows that a patient education program to prevent falls in hospitalized elderly people is effective and cost-saving, provided 4% of these patients would otherwise fall under usual care. |
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Research article
Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack BMC Medicine 2013, 11:134 (21 May 2013) Alloreactive T cells are present in the blood 2 weeks before the onset of acute graft-versus-host disease (GVHD) symptoms in a mouse model, suggesting these cells could be measured to allow early diagnosis and timely therapeutic intervention. |
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Commentary
Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account. |
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Review
Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry. |
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Debate
Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention. |
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Debate
Depression as a non-causal variable risk marker in coronary heart disease Anna Meijer, Marij Zuidersma, Peter de Jonge BMC Medicine 2013, 11:130 (15 May 2013) Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD. |
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Review
Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications. |
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Editorial
The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5. |
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Debate
Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013) Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis. |
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Debate
Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders. |
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Debate
Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders. |
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Review
The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment. |
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Research article
Drug eluting balloons for Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients. |
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Research article
Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance. |
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Research article
Depression, antidepressant medications, and risk of Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients. |
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Review
Novel therapeutic agents in clinical development for systemic lupus erythematosus Natasha Jordan, Pamela MK Lutalo, David P D’Cruz BMC Medicine 2013, 11:120 (3 May 2013) Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials. |
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Opinion
Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations. |
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Question and Answer
Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field. |
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Review
Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD. |
