Articles
Volume 11 (2013) - June 2013
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Review
Kresimir Dolic, Adnan H Siddiqui, Yuval Karmon, Karen Marr, Robert Zivadinov BMC Medicine 2013, 11:155 (27 June 2013) There is currently no standard imaging modality used for detecting extra-cranial venous anomalies; Robert Zivadinov and colleagues review the diagnostic imaging techniques in clinical development, concluding that a multimodal approach is necessary. |
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Review
New insights into mechanisms behind miscarriage Elisabeth Larsen, Ole Christiansen, Astrid Kolte, Nick Macklon BMC Medicine 2013, 11:154 (26 June 2013) Nick Macklon and colleagues review recent advances in elucidating the causes of miscarriage, including genetic and lifestyle factors, and discuss how new therapeutic interventions can be developed with improved understanding. |
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Research article
Andrea C Tricco, Ayman Chit, Charlene Soobiah, David Hallett, Genevieve Meier, Maggie H Chen, Mariam Tashkandi, Chris T Bauch, Mark Loeb BMC Medicine 2013, 11:153 (25 June 2013) Evidence from a systematic review and meta-analysis shows that flu vaccination can protect against infection with a different strain of the virus, but protection is most effective when the vaccine antigens and circulating flu strain match. |
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Review
The differential role of androgens in early human sex development Olaf Hiort BMC Medicine 2013, 11:152 (24 June 2013) Olaf Hiort reviews the mechanisms via which androgens affect early human sex development, and proposes that a response index of androgens should be considered due to the time-sensitive processes controlled by the androgen receptor. |
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Minireview
Genetic heterogeneity in breast cancer: the road to personalized medicine? Richard D Baird, Carlos Caldas BMC Medicine 2013, 11:151 (21 June 2013) Richard Baird and Carlos Caldas review recent progress in the molecular profiling of breast cancer, and discuss how genomics studies have shown variability in different patients, leading to the identification of new prognostic biomarkers. |
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Question and Answer
Video Q&A: molecular profiling of breast cancer Carlos Caldas BMC Medicine 2013, 11:150 (21 June 2013) We talk to Carlos Caldas about the identification of distinct breast cancer subtypes through molecular profiling, and discuss the clinical implications for diagnosis and treatment. |
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Review
Special considerations in prognostic research in cancer involving genetic polymorphisms Sevtap Savas, Geoffrey Liu, Wei Xu BMC Medicine 2013, 11:149 (17 June 2013) Analyzing genetic polymorphisms is important for the development of new cancer biomarkers; Wei Xu and colleagues review special considerations that must be taken into account when studying tumor genetics, and highlight the potential problems. |
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Debate
When to start antiretroviral therapy: the need for an evidence base during early HIV infection Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges, James D Neaton BMC Medicine 2013, 11:148 (14 June 2013) Jens Lundgren and colleagues argue for a more cautious approach to starting antiretroviral therapy, highlighting that there is no evidence from randomized trials to suggest the benefits of starting therapy early outweigh the potential harms. |
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Debate
When to start antiretroviral therapy: as soon as possible Ricardo A Franco, Michael S Saag BMC Medicine 2013, 11:147 (14 June 2013) Ricardo Franco and Michael Saag discuss the benefits of starting HIV therapy early, arguing that treatment should be given as soon as possible to reduce viral replication, prevent transmission and avoid the problems associated with inflammation. |
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Research article
Georg Siegel, Torsten Kluba, Ursula Hermanutz-Klein, Karen Bieback, Hinnak Northoff, Richard Schäfer BMC Medicine 2013, 11:146 (11 June 2013) Mesenchymal stromal cells have potential for clinical application in regenerative medicine, but have varying functional properties owing to donor age and gender, suggesting that identification of these factors are important for clinical use. |
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Minireview
Origins of increased airway smooth muscle mass in asthma Rachid Berair, Ruth Saunders, Christopher E Brightling BMC Medicine 2013, 11:145 (6 June 2013) Christopher Brightling and colleagues discuss the contribution of different cell types to airway smooth muscle hyperplasia, and describe how a greater understanding of these mechanisms will guide the development of new therapies for asthma. |
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Research article
Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:144 (5 June 2013) Ipsilateral joint involvement is shown to affect pain and function outcomes after total hip or knee arthroplasty, indicating that arthroplasty outcomes may be improved if these issues are addressed. |
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Review
The collateral circulation of the heart Pascal Meier, Stephan H Schirmer, Alexandra J Lansky, Adam Timmis, Bertram Pitt, Christian Seiler BMC Medicine 2013, 11:143 (4 June 2013) Pascal Meier and colleagues discuss the relevance of collateral arteries in the heart, and describe recent evidence indicating these arteries have a protective role in preserving myocardial function in patients with coronary heart disease. |
