BMC Medicine | Vol 11 | 2013

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Medicine

Advertisement

Articles

Volume 11 (2013) - August 2013

next >

< previous

Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP BMC Medicine 2013, 11:192 (30 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.

Systematic review of clinical practice guidelines in the diagnosis and management of thyroid nodules and cancer

Tsai-Wei Huang, Jun-Hung Lai, Mei-Yi Wu, Shiah-Lian Chen, Chih-Hsiung Wu, Ka-Wai Tam BMC Medicine 2013, 11:191 (29 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Although clinical practice guidelines (CPGs) are used to diagnose and manage thyroid nodules and cancer, a systematic review finds that recommendations across international CPGs vary in methodological quality, highlighting the need for improvement in the quality of these guidelines.

Rapid diagnostics of tuberculosis and drug resistance in the industrialized world: clinical and public health benefits and barriers to implementation

Francis Drobniewski, Vladyslav Nikolayevskyy, Horst Maxeiner, Yanina Balabanova, Nicola Casali, Irina Kontsevaya, Olga Ignatyeva BMC Medicine 2013, 11:190 (29 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Francis Drobniewski and colleagues review new technologies for the diagnosis of tuberculosis (TB) and drug resistance of immunocompetent patients in the industrialized world, and consider cost-effectiveness, implementation and impact on public health.

Procalcitonin beyond the acute phase: novel biomediator properties?

Carolina Panico, Eric Nylen BMC Medicine 2013, 11:189 (28 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Nylen and Panico comment on recent research indicating that procalcitonin is linked to all-cause mortality and cancer mortality in healthy men, and discuss the potential role of procalcitonin as both a novel biomarker and a biomediator.

A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways

Robert P Anderson, Margaret J Henry, Roberta Taylor, Emma L Duncan, Patrick Danoy, Marylia J Costa, Kathryn Addison, Jason A Tye-Din, Mark A Kotowicz, Ross E Knight, Wendy Pollock, Geoffrey C Nicholson, Ban-Hock Toh, Matthew A Brown, Julie A Pasco BMC Medicine 2013, 11:188 (28 August 2013)

Abstract | Full text | PDF | Editor’s summary

A novel screening approach involving human leukocyte antigen (HLA)-DQ gene testing and confirmatory serology accurately estimates the prevalence of celiac disease (CD), and could help to reduce the number of unnecessary gastroscopies.

Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III

Xinqing Deng, Yiqing Song, JoAnn E Manson, Lisa B Signorello, Shumin M Zhang, Martha J Shrubsole, Reid M Ness, Douglas L Seidner, Qi Dai BMC Medicine 2013, 11:187 (27 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Evidence from the National Health and Nutrition Examination Surveys shows high intake of magnesium is inversely associated with vitamin D insufficiency, and may protect against mortality, although confirmation from clinical trials is needed.

Challenges and opportunities for oral pre-exposure prophylaxis in the prevention of HIV infection: where are we in Europe?

Jean-Michel Molina, Claire Pintado, Caroline Gatey, Diane Ponscarme, Pierre Charbonneau, Benedicte Loze, Willy Rozenbaum, Constance Delaugerre BMC Medicine 2013, 11:186 (23 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Pre-exposure prophylaxis (PrEP) with antiretroviral therapy is thought to help prevent HIV transmission; Jean-Michel Molina and colleagues discuss the controversy surrounding PrEP in Europe, and highlight the issues that need to be addressed.

The Hyperferritinemic Syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome

Cristina Rosário, Gisele Zandman-Goddard, Esther G Meyron-Holtz, David P D’Cruz, Yehuda Shoenfeld BMC Medicine 2013, 11:185 (22 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Yehuda Shoenfeld and colleagues discuss the similar features in macrophage activation syndrome, Still’s disease, antiphospholipid syndrome and septic shock, and propose that they should be grouped together as the Hyperferritinemic Syndrome.

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

George M Warimwe, Helen A Fletcher, Ally Olotu, Selidji T Agnandji, Adrian VS Hill, Kevin Marsh, Philip Bejon BMC Medicine 2013, 11:184 (21 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Variation in RTS,S malaria vaccine efficacy between individuals can be attributed to differences in peripheral blood monocyte-to-lymphocyte ratio measured before vaccination, indicating that individuals most receptive to RTS,S can be targeted.

Pharmacological treatments in ARDS; a state-of-the-art update

Andrew Boyle, Rob Sweeney, Daniel McAuley BMC Medicine 2013, 11:166 (20 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Current treatment of acute respiratory distress syndrome (ARDS) is limited to minimizing potentially harmful ventilation; Daniel McAuley and colleagues review clinical trials of new agents for ARDS and discuss emerging pharmacological therapies.

Therapeutic benefits of an oral vitamin B1 derivative for HAM/TSP

Jun-Ichi Kira BMC Medicine 2013, 11:183 (15 August 2013)

Abstract | Provisional PDF | PubMed | Editor’s summary

Jun-Ichi Kira comments on a recent trial indicating a potentially novel treatment for Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with oral prosultiamine, and discusses its potential to inform future larger trials.

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial

Tatsufumi Nakamura, Tomohiro Matsuo, Taku Fukuda, Shinji Yamato, Kentaro Yamaguchi, Ikuo Kinoshita, Toshio Matsuzaki, Yoshihiro Nishiura, Kunihiko Nagasato, Tomoko Narita-Masuda, Hideki Nakamura, Katsuya Satoh, Hitoshi Sasaki, Hideki Sakai, Atsushi Kawakami BMC Medicine 2013, 11:182 (15 August 2013)

Abstract | Provisional PDF | PubMed | Editor’s summary

A clinical trial shows that prosultiamine has positive effects on both motor and urinary function, and reduces virus levels in patients with Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

Jadwiga A Wedzicha, Simon E Brill, James P Allinson, Gavin C Donaldson BMC Medicine 2013, 11:181 (14 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

The frequent exacerbator phenotype is a distinct clinical subgroup in chronic obstructive pulmonary disease (COPD) patients; Jadwiga Wedzicha and colleagues review the pathophysiology of this phenotype and its interaction with other comorbidities.

Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study

Ovidiu S Cotoi, Jonas Manjer, Bo Hedblad, Gunnar Engström, Olle Melander, Alexandru Schiopu BMC Medicine 2013, 11:180 (13 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Elevated levels of plasma procalcitonin are linked to all-cause mortality and cancer mortality in men with no history of cancer, indicating that procalcitonin could be used as a biomarker to identify healthy men at risk of cancer.

Personalizing health care: feasibility and future implications

Brian Godman, Alexander E Finlayson, Parneet K Cheema, Eva Zebedin-Brandl, Inaki Gutiérrez-Ibarluzea, Jan Jones, Rickard E Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrario, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan Haycox, Harald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Ake Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh et al. BMC Medicine 2013, 11:179 (13 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Brian Godman and colleagues review the challenges and concerns associated with personalized medicine, emphasizing that it has the potential to revolutionize care, but knowledge from a payer’s perspective must be integrated to move forwards.

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

Amarjargal Dashdorj, Jyothi KR, Sangbin Lim, Ara Jo, Minh Nguyen, Joohun Ha, Kyung-Sik Yoon, Hyo Kim, Jae-Hoon Park, Michael P Murphy, Sung Kim BMC Medicine 2013, 11:178 (6 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

The antioxidant MitoQ improves colitis symptoms and reduces inflammation in a mouse model of inflammatory bowel disease (IBD), suggesting that MitoQ could represent a new therapeutic agent for the treatment of acute IBD.

Prehypertension and incidence of cardiovascular disease: a meta-analysis

Yuli Huang, Sheng Wang, Xiaoyan Cai, Weiyi Mai, Yunzhao Hu, Hongfeng Tang, Dingli Xu BMC Medicine 2013, 11:177 (2 August 2013)

A meta-analysis indicates that even low range prehypertension increases the risk of cardiovascular disease (CVD), suggesting that it may be appropriate to subdivide prehypertension in order to identify those most at risk of CVD.

Serum concentrations of 25-hydroxyvitamin D and immunoglobulins in an older Swiss cohort: results of the Senior Labor Study

Benjamin Sakem, Cristina Nock, Zeno Stanga, Pedro Medina, Urs E Nydegger, Martin Risch, Lorenz Risch BMC Medicine 2013, 11:176 (1 August 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Approximately two-thirds of healthy Swiss older people have vitamin D insufficiency, and low levels of vitamin D are associated with changes in humoral immunity, providing further evidence for the role of vitamin D in the immune system.