Articles
Volume 10 (2012) - March 2012
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Opinion
Viral hemorrhagic fevers: advancing the level of treatment Giuseppe Ippolito, Heinz Feldmann, Simone Lanini, Francesco Vairo, Antonino Di Caro, Maria Capobianchi, Emanuele Nicastri BMC Medicine 2012, 10:31 (29 March 2012) Giuseppe Ippolito et al. propose clinical management of viral hemorrhagic fevers (VHFs) should develop beyond simple infection control, and focus on early diagnosis and intervention to improve outcome of patients suffering from this life-threatening disease.
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Research article
Yan Cheng, Wenyuan Wu, Wei Feng, Jiaqi Wang, You Chen, Yuan Shen, Qingwei Li, Xu Zhang, Chunbo Li BMC Medicine 2012, 10:30 (27 March 2012) In healthy elderly people, multi-domain cognitive training can improve memory, reasoning & attention to a greater extent than single-domain training, so could be used to help maintain mental functioning in those at risk of developing dementia.
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Commentary
Sufficient blood, safe blood: can we have both? Halvard Bönig, Michael Schmidt, Kai Hourfar, Jörg Schüttrumpf, Erhard Seifried BMC Medicine 2012, 10:29 (23 March 2012) Blood donor eligibility criteria were relaxed in 2011 to include abstinent men who have sex with men, but should we focus on relaxing the criteria or better recruitment of the eligible non-donor pool? Halvard Bonig et al. discuss the implications.
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Research article
Gang Chen, Peter Kronenberger, Erik Teugels, Ijeoma Umelo, Jacques De Grève BMC Medicine 2012, 10:28 (21 March 2012) siRNA enhances the anti-cancer effects of chemotherapy drugs targeting the EGF receptor in lung cancer cells with drug resistance mutations, highlighting the potential of drug-siRNA combination therapy to overcome resistance.
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Review
Viruses exacerbating chronic pulmonary disease: the role of immune modulation Aran Singanayagam, Priya V Joshi, Patrick Mallia, Sebastian L Johnston BMC Medicine 2012, 10:27 (15 March 2012) Understanding the pathology of chronic pulmonary diseases is needed to develop novel therapeutic strategies; Sebastian Johnston and colleagues discuss the role of immune modulation by respiratory viruses in exacerbating these conditions.
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Research article
Insufficient maintenance DNA methylation is associated with abnormal embryonic development Li-Jun Yin, Yu Zhang, Ping-Ping Lv, Wei-Hua He, Yan-Ting Wu, Ai-Xia Liu, Guo-Lian Ding, Min-Yue Dong, Fan Qu, Chen-Ming Xu, Xiao-Ming Zhu, He-Feng Huang BMC Medicine 2012, 10:26 (13 March 2012) Embryonic, but not maternal, defects in DNA methylation are associated with early pregnancy loss (EPL), and disrupting DNA methylation in mice causes impaired embryonic development, providing new insight into the mechanisms behind EPL.
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Minireview
Advances in using PARP inhibitors to treat cancer Shivaani Kummar, Alice Chen, Ralph E Parchment, Robert J Kinders, Jay Ji, Joseph E Tomaszewski, James H Doroshow BMC Medicine 2012, 10:25 (9 March 2012) Doroshow and colleagues review the clinical development, mechanism of action and efficacy of new therapies for breast and ovarian cancer targeting PARP family DNA repair enzymes, and discuss their use in combination with other cancer drugs.
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Research article
Melissa Bowerman, Lyndsay M Murray, Justin G Boyer, Carrie L Anderson, Rashmi Kothary BMC Medicine 2012, 10:24 (7 March 2012) Fasudil, a ROCK inhibitor already clinically approved for trials in other conditions, improves survival of a spinal muscular atrophy (SMA) mouse model via muscle-specific mechanisms, and may be a promising form of therapy for this incurable disease.
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Review
Therapy for metastatic melanoma: the past, present, and future Laura Finn, Svetomir N Markovic, Richard W Joseph BMC Medicine 2012, 10:23 (2 March 2012) Vemurafenib and ipilimumab have recently been approved to treat metastatic melanoma; here Markovic and colleagues review the mode of action as well as limitations of these agents, and the implications on future clinical trials.
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