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		Research article Transmission potential of influenza A/H7N9, February to May 2013, China Gerardo Chowell, Lone Simonsen, Sherry Towers, Mark A Miller, Cécile Viboud BMC Medicine 2013, 11:214 (2 October 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical models suggest the novel influenza A/H7N9 virus has low transmission potential in China, but continued monitoring is warranted as changing seasonal factors and relaxed interventional measures might promote its spread.
		Research article Development and evaluation of the feasibility and effects on staff, patients, and families of a new tool, the Psychosocial Assessment and Communication Evaluation (PACE), to improve communication and palliative care in intensive care and during clinical uncertainty Irene J Higginson, Jonathan Koffman, Philip Hopkins, Wendy Prentice, Rachel Burman, Sara Leonard, Caroline Rumble, Jo Noble, Odette Dampier, William Bernal, Sue Hall, Myfanwy Morgan, Cathy Shipman BMC Medicine 2013, 11:213 (1 October 2013) Abstract \| Provisional PDF \| Editor’s summary A new tool, Psychosocial Assessment and Communication Evaluation (PACE), shows promising results in improving communication and palliative care for both patients and their families during clinical uncertainty in intensive care units (ICU).
		Research article Hypnotics and mortality in an elderly general population: a 12-year prospective study Isabelle Jaussent, Marie-Laure Ancelin, Claudine Berr, Karine Pérès, Jacqueline Scali, Alain Besset, Karen Ritchie, Yves Dauvilliers BMC Medicine 2013, 11:212 (26 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary When adjusting for a range of confounders, the use of hypnotics is not significantly associated with increased mortality risk in older people, suggesting that underlying comorbidities could explain previous controversial findings.
		Commentary Pre-hypertension: another ‘pseudodisease’? Pascal Meier, Franz H Messerli, Andreas Baumbach, Alexandra J Lansky BMC Medicine 2013, 11:211 (25 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary Pascal Meier and colleagues comment on a recent meta-analysis indicating that prehypertension is a risk factor for cardiovascular disease (CVD), and discuss the implications of reclassifying hypertension ranges to incorporate prehypertensive patients.
		Research article Patients with osteoarthritis and avascular necrosis have better functional outcomes and those with avascular necrosis worse pain outcomes compared to rheumatoid arthritis after primary hip arthroplasty: a cohort study Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:210 (24 September 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Patients with osteoarthritis, avascular necrosis and rheumatoid arthritis have different functional and pain outcomes following total hip arthroplasty, meaning that more realistic post-surgery expectations can now be made for each patient group.
		Research article Perineal Assessment and Repair Longitudinal Study (PEARLS): a matched-pair cluster randomized trial Khaled M K Ismail, Christine Kettle, Sue E Macdonald, Sue Tohill, Peter W Thomas, Debra Bick BMC Medicine 2013, 11:209 (23 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women with perineal trauma after childbirth have lower risk of wound infection when managed by healthcare practitioners who undergo evidence-based perineal trauma training, suggesting that this training may improve some maternal clinical outcomes.
		Research article Mediterranean dietary pattern and depression: the PREDIMED randomized trial Almudena Sánchez-Villegas, Miguel Martínez-González, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Maria Covas, Fernando Arós, Dora Romaguera, Enrique Gómez-Gracia, José Lapetra, Xavier Pintó, Jose Martínez, Rosa Lamuela-Raventós, Emilio Ros, Alfredo Gea, Julia Wärnberg, Lluis Serra-Majem BMC Medicine 2013, 11:208 (20 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Patients with high cardiovascular disease risk and type 2 diabetes on a Mediterranean diet supplemented with nuts have lower risk of depression than those on a low-fat diet, suggesting nuts have a beneficial effect on mental health in this population.
		Research article Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial Estefania Toledo, Frank B Hu, Ramon Estruch, Pilar Buil-Cosiales, Dolores Corella, Jordi Salas-Salvadó, M Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Jose Lapetra, Luis Serra-Majem, Xavier Pinto, Rosa M Lamuela-Raventós, Guillermo Saez, Mònica Bulló, Valentina Ruiz-Gutiérrez, Emilio Ros, José V Sorli, Miguel Martinez-Gonzalez BMC Medicine 2013, 11:207 (19 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In individuals with high cardiovascular disease risk, eating a Mediterranean diet supplemented with olive oil or nuts reduces diastolic blood pressure (BP) more than a low-fat diet, suggesting the Mediterranean diet could be beneficial for BP control.
		Research article Comparing sociocultural features of cholera in three endemic African settings Christian Schaetti, Neisha Sundaram, Sonja Merten, Said M Ali, Erick O Nyambedha, Bruno Lapika, Claire-Lise Chaignat, Raymond Hutubessy, Mitchell G Weiss BMC Medicine 2013, 11:206 (18 September 2013) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Investigation into sociocultural features of endemic cholera in three African countries finds both common and distinct health-seeking and knowledge patterns, which could be used to guide planning for future cholera control and elimination.
		Opinion Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics Gerwyn Morris, Michael Maes BMC Medicine 2013, 11:205 (17 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary As multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and neuro-immune characteristics, Gerwyn Morris and Michael Maes suggest that CFS should be considered as a neuro-immune disease and that MS patients may be susceptible to develop CFS symptoms.
		Question and Answer DSM-5 and ADHD – an interview with Eric Taylor Eric Taylor BMC Medicine 2013, 11:204 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In this Q&A audio podcast, we interview child and adolescent psychiatrist Eric Taylor about the revisions to the diagnosis of attention deficit hyperactivity disorder (ADHD) in DSM-5, and explore how these changes will affect clinical practice.
		Question and Answer The DSM-5 - an interview with David Kupfer David Kupfer BMC Medicine 2013, 11:203 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In this Q&A audio podcast, we interview David Kupfer, chair of the task force for the fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), on the challenges and future directions of psychiatric diagnosis.
		Forum DSM-5: a collection of psychiatrist views on the changes, controversies, and future directions Charles B Nemeroff, Daniel Weinberger, Michael Rutter, Harriet L MacMillan, Richard A Bryant, Simon Wessely, Dan J Stein, Carmine M Pariante, Florian Seemüller, Michael Berk, Gin S Malhi, Martin Preisig, Martin Brüne, Paul Lysaker BMC Medicine 2013, 11:202 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Our Editorial Board Members and their colleagues discuss their personal views on the newly released fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), specifically with regard to how it may, or may not, affect their specific areas of psychiatric medicine.
		Commentary Diagnostic heterogeneity in psychiatry: towards an empirical solution Klaas J Wardenaar, Peter de Jonge BMC Medicine 2013, 11:201 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Given the current challenges in psychiatric medicine, Klaas Wardenaar and Peter de Jonge argue that evidence-based diagnostic methods should be developed by using multimode analysis and modelling to assess heterogeneity across persons and symptoms over time, to accurately identify optimal homogeneous subgroups.
		Opinion So depression is an inflammatory disease, but where does the inflammation come from? Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes BMC Medicine 2013, 11:200 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Depression is associated with a low-grade inflammatory response; Michael Berk and colleagues discuss the sources of inflammation, oxidative and nitrosative stress in depression and emphasize that these factors can be treated or prevented.
		Commentary Increasing the dose of acute rehabilitation: is there a benefit? Ann M Parker, Robert K Lord, Dale M Needham BMC Medicine 2013, 11:199 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Dale Needham and colleagues comment on results from a clinical trial showing that additional Saturday rehabilitation improves outcome in hospitalized patients, and discuss the motivational benefits of physiotherapy and occupational therapy.
		Research article Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts, Nicholas F Taylor BMC Medicine 2013, 11:198 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In a clinical trial, additional Saturday rehabilitation improves functional independence and quality of life in hospitalized patients, and could reduce length of hospital stay, suggesting extra rehabilitation should be given to improve patient outcome.
		Minireview What is next after the genes for autoimmunity? John Castiblanco, Mauricio Arcos-Burgos, Juan-Manuel Anaya BMC Medicine 2013, 11:197 (4 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Autoimmune diseases have complex etiology and are known to aggregate in families; Juan-Manuel Anaya and colleagues review the genetic components of autoimmunity and discuss the challenges associated with genetic analysis and disease prediction.
		Commentary Is it smoking or related lifestyle variables that increase metabolic syndrome risk? Mikael Rabaeus, Patricia Salen, Michel de Lorgeril BMC Medicine 2013, 11:196 (3 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Michel de Lorgeril and colleagues comment on a study showing that smoking is associated with metabolic syndrome (MetS), and discuss how other lifestyle factors such as physical inactivity and alcohol consumption could explain the link.
		Research article Associations between smoking, components of metabolic syndrome and lipoprotein particle size Sandra N Slagter, Jana Vliet-Ostaptchouk, Judith M Vonk, H Boezen, Robin PF Dullaart, Anneke C Muller Kobold, Edith J Feskens, André Beek, Melanie Klauw, Bruce HR Wolffenbuttel BMC Medicine 2013, 11:195 (3 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Smoking is associated with increased prevalence of metabolic syndrome irrespective of sex or body mass index, and the association is related to lipid changes, providing a mechanism linking smoking to increased risk of cardiovascular disease.
		Research article A method for inferring medical diagnoses from patient similarities Assaf Gottlieb, Gideon Y Stein, Eytan Ruppin, Russ B Altman, Roded Sharan BMC Medicine 2013, 11:194 (2 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new method using detailed population based information in electronic health records, can accurately predict discharge diagnosis of patients with acute and chronic diseases and can assist physicians with medical decisions.
		Correction Correction: Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List BMC Medicine 2013, 11:193 (2 September 2013) Abstract \| Full text \| PDF
		Research article Alcohol intake, wine consumption and the development of depression: the PREDIMED study Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP BMC Medicine 2013, 11:192 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.
		Research article Systematic review of clinical practice guidelines in the diagnosis and management of thyroid nodules and cancer Tsai-Wei Huang, Jun-Hung Lai, Mei-Yi Wu, Shiah-Lian Chen, Chih-Hsiung Wu, Ka-Wai Tam BMC Medicine 2013, 11:191 (29 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Although clinical practice guidelines (CPGs) are used to diagnose and manage thyroid nodules and cancer, a systematic review finds that recommendations across international CPGs vary in methodological quality, highlighting the need for improvement in the quality of these guidelines.
		Review Rapid diagnostics of tuberculosis and drug resistance in the industrialized world: clinical and public health benefits and barriers to implementation Francis Drobniewski, Vladyslav Nikolayevskyy, Horst Maxeiner, Yanina Balabanova, Nicola Casali, Irina Kontsevaya, Olga Ignatyeva BMC Medicine 2013, 11:190 (29 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Francis Drobniewski and colleagues review new technologies for the diagnosis of tuberculosis (TB) and drug resistance of immunocompetent patients in the industrialized world, and consider cost-effectiveness, implementation and impact on public health.

	All
		Research article Transmission potential of influenza A/H7N9, February to May 2013, China Gerardo Chowell, Lone Simonsen, Sherry Towers, Mark A Miller, Cécile Viboud BMC Medicine 2013, 11:214 (2 October 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical models suggest the novel influenza A/H7N9 virus has low transmission potential in China, but continued monitoring is warranted as changing seasonal factors and relaxed interventional measures might promote its spread.
		Research article Development and evaluation of the feasibility and effects on staff, patients, and families of a new tool, the Psychosocial Assessment and Communication Evaluation (PACE), to improve communication and palliative care in intensive care and during clinical uncertainty Irene J Higginson, Jonathan Koffman, Philip Hopkins, Wendy Prentice, Rachel Burman, Sara Leonard, Caroline Rumble, Jo Noble, Odette Dampier, William Bernal, Sue Hall, Myfanwy Morgan, Cathy Shipman BMC Medicine 2013, 11:213 (1 October 2013) Abstract \| Provisional PDF \| Editor’s summary A new tool, Psychosocial Assessment and Communication Evaluation (PACE), shows promising results in improving communication and palliative care for both patients and their families during clinical uncertainty in intensive care units (ICU).
		Research article Hypnotics and mortality in an elderly general population: a 12-year prospective study Isabelle Jaussent, Marie-Laure Ancelin, Claudine Berr, Karine Pérès, Jacqueline Scali, Alain Besset, Karen Ritchie, Yves Dauvilliers BMC Medicine 2013, 11:212 (26 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary When adjusting for a range of confounders, the use of hypnotics is not significantly associated with increased mortality risk in older people, suggesting that underlying comorbidities could explain previous controversial findings.
		Commentary Pre-hypertension: another ‘pseudodisease’? Pascal Meier, Franz H Messerli, Andreas Baumbach, Alexandra J Lansky BMC Medicine 2013, 11:211 (25 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary Pascal Meier and colleagues comment on a recent meta-analysis indicating that prehypertension is a risk factor for cardiovascular disease (CVD), and discuss the implications of reclassifying hypertension ranges to incorporate prehypertensive patients.
		Research article Patients with osteoarthritis and avascular necrosis have better functional outcomes and those with avascular necrosis worse pain outcomes compared to rheumatoid arthritis after primary hip arthroplasty: a cohort study Jasvinder A Singh, David G Lewallen BMC Medicine 2013, 11:210 (24 September 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Patients with osteoarthritis, avascular necrosis and rheumatoid arthritis have different functional and pain outcomes following total hip arthroplasty, meaning that more realistic post-surgery expectations can now be made for each patient group.
		Research article Perineal Assessment and Repair Longitudinal Study (PEARLS): a matched-pair cluster randomized trial Khaled M K Ismail, Christine Kettle, Sue E Macdonald, Sue Tohill, Peter W Thomas, Debra Bick BMC Medicine 2013, 11:209 (23 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women with perineal trauma after childbirth have lower risk of wound infection when managed by healthcare practitioners who undergo evidence-based perineal trauma training, suggesting that this training may improve some maternal clinical outcomes.
		Research article Mediterranean dietary pattern and depression: the PREDIMED randomized trial Almudena Sánchez-Villegas, Miguel Martínez-González, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Maria Covas, Fernando Arós, Dora Romaguera, Enrique Gómez-Gracia, José Lapetra, Xavier Pintó, Jose Martínez, Rosa Lamuela-Raventós, Emilio Ros, Alfredo Gea, Julia Wärnberg, Lluis Serra-Majem BMC Medicine 2013, 11:208 (20 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Patients with high cardiovascular disease risk and type 2 diabetes on a Mediterranean diet supplemented with nuts have lower risk of depression than those on a low-fat diet, suggesting nuts have a beneficial effect on mental health in this population.
		Research article Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial Estefania Toledo, Frank B Hu, Ramon Estruch, Pilar Buil-Cosiales, Dolores Corella, Jordi Salas-Salvadó, M Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Jose Lapetra, Luis Serra-Majem, Xavier Pinto, Rosa M Lamuela-Raventós, Guillermo Saez, Mònica Bulló, Valentina Ruiz-Gutiérrez, Emilio Ros, José V Sorli, Miguel Martinez-Gonzalez BMC Medicine 2013, 11:207 (19 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In individuals with high cardiovascular disease risk, eating a Mediterranean diet supplemented with olive oil or nuts reduces diastolic blood pressure (BP) more than a low-fat diet, suggesting the Mediterranean diet could be beneficial for BP control.
		Research article Comparing sociocultural features of cholera in three endemic African settings Christian Schaetti, Neisha Sundaram, Sonja Merten, Said M Ali, Erick O Nyambedha, Bruno Lapika, Claire-Lise Chaignat, Raymond Hutubessy, Mitchell G Weiss BMC Medicine 2013, 11:206 (18 September 2013) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Investigation into sociocultural features of endemic cholera in three African countries finds both common and distinct health-seeking and knowledge patterns, which could be used to guide planning for future cholera control and elimination.
		Opinion Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics Gerwyn Morris, Michael Maes BMC Medicine 2013, 11:205 (17 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary As multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and neuro-immune characteristics, Gerwyn Morris and Michael Maes suggest that CFS should be considered as a neuro-immune disease and that MS patients may be susceptible to develop CFS symptoms.
		Question and Answer DSM-5 and ADHD – an interview with Eric Taylor Eric Taylor BMC Medicine 2013, 11:204 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In this Q&A audio podcast, we interview child and adolescent psychiatrist Eric Taylor about the revisions to the diagnosis of attention deficit hyperactivity disorder (ADHD) in DSM-5, and explore how these changes will affect clinical practice.
		Question and Answer The DSM-5 - an interview with David Kupfer David Kupfer BMC Medicine 2013, 11:203 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In this Q&A audio podcast, we interview David Kupfer, chair of the task force for the fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), on the challenges and future directions of psychiatric diagnosis.
		Forum DSM-5: a collection of psychiatrist views on the changes, controversies, and future directions Charles B Nemeroff, Daniel Weinberger, Michael Rutter, Harriet L MacMillan, Richard A Bryant, Simon Wessely, Dan J Stein, Carmine M Pariante, Florian Seemüller, Michael Berk, Gin S Malhi, Martin Preisig, Martin Brüne, Paul Lysaker BMC Medicine 2013, 11:202 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Our Editorial Board Members and their colleagues discuss their personal views on the newly released fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), specifically with regard to how it may, or may not, affect their specific areas of psychiatric medicine.
		Commentary Diagnostic heterogeneity in psychiatry: towards an empirical solution Klaas J Wardenaar, Peter de Jonge BMC Medicine 2013, 11:201 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Given the current challenges in psychiatric medicine, Klaas Wardenaar and Peter de Jonge argue that evidence-based diagnostic methods should be developed by using multimode analysis and modelling to assess heterogeneity across persons and symptoms over time, to accurately identify optimal homogeneous subgroups.
		Opinion So depression is an inflammatory disease, but where does the inflammation come from? Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes BMC Medicine 2013, 11:200 (12 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Depression is associated with a low-grade inflammatory response; Michael Berk and colleagues discuss the sources of inflammation, oxidative and nitrosative stress in depression and emphasize that these factors can be treated or prevented.
		Commentary Increasing the dose of acute rehabilitation: is there a benefit? Ann M Parker, Robert K Lord, Dale M Needham BMC Medicine 2013, 11:199 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Dale Needham and colleagues comment on results from a clinical trial showing that additional Saturday rehabilitation improves outcome in hospitalized patients, and discuss the motivational benefits of physiotherapy and occupational therapy.
		Research article Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts, Nicholas F Taylor BMC Medicine 2013, 11:198 (10 September 2013) Abstract \| Full text \| PDF \| Editor’s summary In a clinical trial, additional Saturday rehabilitation improves functional independence and quality of life in hospitalized patients, and could reduce length of hospital stay, suggesting extra rehabilitation should be given to improve patient outcome.
		Minireview What is next after the genes for autoimmunity? John Castiblanco, Mauricio Arcos-Burgos, Juan-Manuel Anaya BMC Medicine 2013, 11:197 (4 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Autoimmune diseases have complex etiology and are known to aggregate in families; Juan-Manuel Anaya and colleagues review the genetic components of autoimmunity and discuss the challenges associated with genetic analysis and disease prediction.
		Commentary Is it smoking or related lifestyle variables that increase metabolic syndrome risk? Mikael Rabaeus, Patricia Salen, Michel de Lorgeril BMC Medicine 2013, 11:196 (3 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Michel de Lorgeril and colleagues comment on a study showing that smoking is associated with metabolic syndrome (MetS), and discuss how other lifestyle factors such as physical inactivity and alcohol consumption could explain the link.
		Research article Associations between smoking, components of metabolic syndrome and lipoprotein particle size Sandra N Slagter, Jana Vliet-Ostaptchouk, Judith M Vonk, H Boezen, Robin PF Dullaart, Anneke C Muller Kobold, Edith J Feskens, André Beek, Melanie Klauw, Bruce HR Wolffenbuttel BMC Medicine 2013, 11:195 (3 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Smoking is associated with increased prevalence of metabolic syndrome irrespective of sex or body mass index, and the association is related to lipid changes, providing a mechanism linking smoking to increased risk of cardiovascular disease.
		Research article A method for inferring medical diagnoses from patient similarities Assaf Gottlieb, Gideon Y Stein, Eytan Ruppin, Russ B Altman, Roded Sharan BMC Medicine 2013, 11:194 (2 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new method using detailed population based information in electronic health records, can accurately predict discharge diagnosis of patients with acute and chronic diseases and can assist physicians with medical decisions.
		Correction Correction: Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List BMC Medicine 2013, 11:193 (2 September 2013) Abstract \| Full text \| PDF
		Research article Alcohol intake, wine consumption and the development of depression: the PREDIMED study Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP BMC Medicine 2013, 11:192 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.
		Research article Systematic review of clinical practice guidelines in the diagnosis and management of thyroid nodules and cancer Tsai-Wei Huang, Jun-Hung Lai, Mei-Yi Wu, Shiah-Lian Chen, Chih-Hsiung Wu, Ka-Wai Tam BMC Medicine 2013, 11:191 (29 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Although clinical practice guidelines (CPGs) are used to diagnose and manage thyroid nodules and cancer, a systematic review finds that recommendations across international CPGs vary in methodological quality, highlighting the need for improvement in the quality of these guidelines.
		Review Rapid diagnostics of tuberculosis and drug resistance in the industrialized world: clinical and public health benefits and barriers to implementation Francis Drobniewski, Vladyslav Nikolayevskyy, Horst Maxeiner, Yanina Balabanova, Nicola Casali, Irina Kontsevaya, Olga Ignatyeva BMC Medicine 2013, 11:190 (29 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Francis Drobniewski and colleagues review new technologies for the diagnosis of tuberculosis (TB) and drug resistance of immunocompetent patients in the industrialized world, and consider cost-effectiveness, implementation and impact on public health.