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		Commentary Patient advocacy and dsm-5 Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Abstract \| Provisional PDF \| Editor’s summary Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.
		Review Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Abstract \| Provisional PDF \| Editor’s summary Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.
		Debate Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Abstract \| Provisional PDF \| Editor’s summary Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.
		Debate Depression as a non-causal variable risk marker in coronary heart disease Anna Meijer, Marij Zuidersma, Peter Jonge BMC Medicine 2013, 11:130 (15 May 2013) Abstract \| Provisional PDF \| Editor’s summary Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD.
		Review Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.
		Editorial The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5.
		Debate Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis.
		Debate Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders.
		Debate Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders.
		Review The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment.
		Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
		Research article Characteristics, changes and influence of body composition during a 4486km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
		Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
		Review Novel therapeutic agents in clinical development for Systemic Lupus Erythematosus Natasha Jordan, Pamela M K Lutalo, David P D'Cruz BMC Medicine 2013, 11:120 (3 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials.
		Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
		Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
		Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
		Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
		Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
		Research article Effects of breastfeeding on body composition and maturational tempo in the rat Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg BMC Medicine 2013, 11:114 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaning from lactation at an early age leads to faster development and leaner, longer bodies in comparison to late-weaned rats, and these effects are transmitted through generations as early-weaned progeny reach sexual maturation at an earlier age.
		Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
		Research article Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten BMC Medicine 2013, 11:112 (26 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary When compared with universal rotavirus (RV) vaccination, targeted vaccination of high-risk children is highly cost-effective in the Netherlands, suggesting that targeted strategies should be used to reduce RV hospitalizations in Europe.
		Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
		Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.

	All
		Commentary Patient advocacy and dsm-5 Dan J Stein, Katharine A Phillips BMC Medicine 2013, 11:133 (17 May 2013) Abstract \| Provisional PDF \| Editor’s summary Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.
		Review Personalized medicine in psychiatry: problems and promises Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff BMC Medicine 2013, 11:132 (16 May 2013) Abstract \| Provisional PDF \| Editor’s summary Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.
		Debate Depression as a risk factor for adverse outcomes in coronary heart disease Kenneth E Freedland, Robert M Carney BMC Medicine 2013, 11:131 (15 May 2013) Abstract \| Provisional PDF \| Editor’s summary Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.
		Debate Depression as a non-causal variable risk marker in coronary heart disease Anna Meijer, Marij Zuidersma, Peter Jonge BMC Medicine 2013, 11:130 (15 May 2013) Abstract \| Provisional PDF \| Editor’s summary Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD.
		Review Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs BMC Medicine 2013, 11:129 (15 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Consequences of depression include somatic diseases, such as obesity and cardiovascular disease; Brenda Penninx and colleagues review the biological pathways and their dysregulation between depressive symptoms and somatic health, and describe the therapeutic implications.
		Editorial The DSM-5: Hyperbole, Hope or Hypothesis? Michael Berk BMC Medicine 2013, 11:128 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Current Controversies in Psychiatry, Michael Berk discusses the debate on diagnostic categories in mental health based on the new edition of diagnostic criteria; the DSM-5.
		Debate Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis.
		Debate Toward the future of psychiatric diagnosis: the seven pillars of RDoC Bruce N Cuthbert, Thomas R Insel BMC Medicine 2013, 11:126 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bruce Cuthbert and Thomas Insel argue that future psychiatric nosologies will be informed by the Research Domain Criteria (RDoC) that is based on genetics, neuroscience and behavioural science, which will help achieve precision medicine for mental disorders.
		Debate Clinical classification in mental health at the cross-roads: which direction next? Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry BMC Medicine 2013, 11:125 (14 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is much debate on DSM-5 diagnosis in mental health, and Ian Hickie and colleagues argue for the development of new approaches that identify pathways underlying the illnesses rather than using broad categories to describe psychiatric disorders.
		Review The genomic landscape of chronic lymphocytic leukemia: clinical implications Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín BMC Medicine 2013, 11:124 (9 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Carlos Lopez-Otin and colleagues review new developments in understanding the genomics of chronic lymphocytic leukemia, and discuss how genomic advances could benefit disease staging and treatment.
		Research article Drug eluting balloons for de novo coronary lesions – a systematic review and meta-analysis Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier BMC Medicine 2013, 11:123 (8 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Evidence from a systematic review and meta-analysis shows the performance of drug-eluting balloons (DEB) is comparable with standard therapy and better than bare metal stents for de novo coronary lesions, so DEB could be considered in these patients.
		Research article Characteristics, changes and influence of body composition during a 4486km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann BMC Medicine 2013, 11:122 (8 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Significant changes in total, somatic and visceral volumes assessed by MRI occurred in 22 ultramarathon runners over the course of a 4487 km race, but body and fat volume, together with body mass, were not associated with race performance.
		Research article Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.
		Review Novel therapeutic agents in clinical development for Systemic Lupus Erythematosus Natasha Jordan, Pamela M K Lutalo, David P D'Cruz BMC Medicine 2013, 11:120 (3 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Traditional treatments for systemic lupus erythematosus (SLE) are associated with toxicity and resistance problems; David D’Cruz and colleagues review novel therapies in clinical development for SLE and discuss results from recent clinical trials.
		Opinion Developmental heterochrony and the evolution of autistic perception, cognition and behavior Bernard Crespi BMC Medicine 2013, 11:119 (2 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernard Crespi proposes that changes in rate and timing of childhood developmental processes may underlie autism and other cognitive and behavioural disorders, and suggests future genetic research should focus on the causes of these variations.
		Question and Answer Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld Yehuda Shoenfeld BMC Medicine 2013, 11:118 (1 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this Q&A we talk to Yehuda Shoenfeld about the syndrome, ASIA (Autoimmune or Autoinflammatory Syndrome Induced by Adjuvants) and discuss his recommendations regarding further research in the field.
		Review Immunity, atherosclerosis and cardiovascular disease Johan Frostegård BMC Medicine 2013, 11:117 (1 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Johan Frostegard reviews the inflammatory mechanisms behind atherosclerosis and cardiovascular disease (CVD), and discusses how inflammation can be targeted in order to develop novel therapies for CVD.
		Editorial Evolutionary medicine – the quest for a better understanding of health, disease and prevention Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.
		Review New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Frank Rühli, Maciej Henneberg BMC Medicine 2013, 11:115 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Rühli and Maciej Henneberg review the microevolutionary changes in humans, and the impact this may have in treatment of diseases, understanding host-pathogen co-evolution, and the effect current clinical decisions may have on future generations.
		Research article Effects of breastfeeding on body composition and maturational tempo in the rat Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg BMC Medicine 2013, 11:114 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaning from lactation at an early age leads to faster development and leaner, longer bodies in comparison to late-weaned rats, and these effects are transmitted through generations as early-weaned progeny reach sexual maturation at an earlier age.
		Review Evo-devo of human adolescence: beyond disease models of early puberty Ze'ev Hochberg, Jay Belsky BMC Medicine 2013, 11:113 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ze’ev Hochberg and Jay Belsky review the development of human adolescents from an endocrinological and social perspective, arguing that understanding the environmental impact on development will help inform further research.
		Research article Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten BMC Medicine 2013, 11:112 (26 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary When compared with universal rotavirus (RV) vaccination, targeted vaccination of high-risk children is highly cost-effective in the Netherlands, suggesting that targeted strategies should be used to reduce RV hospitalizations in Europe.
		Research article Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd, on behalf of MORECare BMC Medicine 2013, 11:111 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Irene Higginson and colleagues present the MORECare statement, an evidence-based set of recommendations for improved research methods in end of life care, which aims to provide clear standards and guidance in this overlooked area of medicine.
		Research article Physical comorbidities in men with mood and anxiety disorders: a population-based study Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams BMC Medicine 2013, 11:110 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mood and anxiety disorders are associated with a range of physical comorbidities in men, and having these disorders increases the risk of high medical burden, providing further evidence for the link between mental and physical health.
		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.