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Immunogenetics

This section aims to publish studies looking at the genes involved in immunological responses and immune cell regulation. The section also welcomes submissions on the immunogenetics of cell interactions, immunogenetics of tissue differentiation and development, genetic control of immune response and disease susceptibility and genetics of responses to alloantigens.

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1.

Research article   Open Access

Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus

Yingxia Liu, Shaoyuan Li, Guoliang Zhang, Guang Nie, Zhizhong Meng, Dongting Mao, Chang Chen, Xinchun Chen, Boping Zhou, Gucheng Zeng BMC Immunology 2013, 14:37 (8 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

2.

Research article   Open Access Highly Accessed

MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)

Margareta Jernås, Clas Malmeström, Markus Axelsson, Intawat Nookaew, Hans Wadenvik, Jan Lycke, Bob Olsson BMC Immunology 2013, 14:32 (29 July 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Genome-wide expression analyses in T-cells from multiple sclerosis (MS) patients identifies multiple differentially expressed microRNAs that affect the expression of target genes associated with the immune system, suggesting a important regulatory role for microRNA in MS.

3.

Research article   Open Access

The impact of polymorphisms in STAT6 on treatment outcome in HCV infected Taiwanese Chinese

Yun-Ping Lim, Yu-An Hsu, Kun-Hsi Tsai, Fuu-Jen Tsai, Cheng-Yuan Peng, Wen-Ling Liao, Dong-Zong Hung, Ni Tien, Chien-Yih Lin, Lei Wan BMC Immunology 2013, 14:21 (8 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

Research article   Open Access

Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels

Winnie A Okeyo, Elly O Munde, Wilson Okumu, Evans Raballah, Samuel B Anyona, John M Vulule, John M Ong’echa, Douglas J Perkins, Collins Ouma BMC Immunology 2013, 14:15 (25 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research article   Open Access

Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum

Yuki Hitomi, Takahiro Adachi, Naoyuki Tsuchiya, Zen-Ichiro Honda, Katsushi Tokunaga, Takeshi Tsubata BMC Immunology 2012, 13:72 (26 December 2012)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access

Sequence-based in silico analysis of well studied Hepatitis C Virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds

Nishi Prabdial-Sing, Adrian J Puren, Sheila M Bowyer BMC Immunology 2012, 13:67 (10 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research article   Open Access

The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

Anke Wesselius, Martijn JL Bours, Ilja CW Arts, Esther HE Theunisz, Piet Geusens, Pieter C Dagnelie BMC Immunology 2012, 13:64 (4 December 2012)

Abstract | Full text | PDF | PubMed

8.

Research article   Open Access Highly Accessed

Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

Nils-Holger Zschemisch, Silke Glage, Dirk Wedekind, Edward J Weinstein, Xiaoxia Cui, Martina Dorsch, Hans-Jürgen Hedrich BMC Immunology 2012, 13:60 (8 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Zinc-finger nuclease mediated disruption of Rag1 produced a mutant rat with a complete depletion of mature B cells, hypoplastic thymus, and lack of lymphocytes in the spleen and lymph nodes, representing a potentially useful model for transplantation studies.

9.

Research article   Open Access Highly Accessed

Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates

Paul J Groot-Kormelink, Lindsay Fawcett, Paul D Wright, Martin Gosling, Toby C Kent BMC Immunology 2012, 13:57 (26 October 2012)

Abstract | Full text | PDF | PubMed

10.

Research article   Open Access Highly Accessed

Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoire

Peter A Larsen, Timothy P L Smith BMC Immunology 2012, 13:52 (14 September 2012)

Abstract | Full text | PDF | PubMed

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