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1.

9500
Accesses

Research article   Open Access Highly Accessed

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Mari Palgi, Dario Greco, Riitta Lindström, Petri Auvinen, Tapio I Heino BMC Genomics 2012, 13:134 (11 April 2012)

Abstract | Full text | PDF | PubMed

2.

5809
Accesses

Research article   Open Access Highly Accessed

The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild

Javier Prado-Martinez, Irene Hernando-Herraez, Belen Lorente-Galdos, Marc Dabad, Oscar Ramirez, Carlos Baeza-Delgado, Carlos Morcillo-Suarez, Can Alkan, Fereydoun Hormozdiari, Emanuele Raineri, Jordi Estellé, Marcos Fernandez-Callejo, Mònica Valles, Lars Ritscher, Torsten Schöneberg, Elisa de la Calle-Mustienes, Sònia Casillas, Raquel Rubio-Acero, Marta Melé, Johannes Engelken, Mario Caceres, Jose Gomez-Skarmeta, Marta Gut, Jaume Bertranpetit, Ivo G Gut, Teresa Abello, Evan E Eichler, Ismael Mingarro, Carles Lalueza-Fox, Arcadi Navarro, Tomas Marques-Bonet et al. BMC Genomics 2013, 14:363 (31 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A phenotypically unique gorilla carries a private non-synonymous substitution in a transmembrane domain in SLC45A2, one of the candidate genes associated with the OCA4 class of albinism

3.

5792
Accesses

Research article   Open Access Highly Accessed

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

Michael A Quail, Miriam Smith, Paul Coupland, Thomas D Otto, Simon R Harris, Thomas R Connor, Anna Bertoni, Harold P Swerdlow, Yong Gu BMC Genomics 2012, 13:341 (24 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequencing of four microbial genomes with widely differing GC content is compared on performance using three major new platforms: Ion Torrent PGM, Pacific Biosciences RS, and illumina MiSeq versus Illumina HiSeq system.

4.

2008
Accesses

Methodology article   Open Access Highly Accessed

Optimizing de novo assembly of short-read RNA-seq data for phylogenomics

Ya Yang, Stephen A Smith BMC Genomics 2013, 14:328 (14 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

1873
Accesses

Software   Open Access

Web-based visual analysis for high-throughput genomics

Jeremy Goecks, Carl Eberhard, Tomithy Too, Anton Nekrutenko, James Taylor BMC Genomics 2013, 14:397 (13 June 2013)

Abstract | Provisional PDF | PubMed

6.

1660
Accesses

Methodology article   Open Access Highly Accessed

Phase-defined complete sequencing of the HLA genes by next-generation sequencing

Kazuyoshi Hosomichi, Timothy A Jinam, Shigeki Mitsunaga, Hirofumi Nakaoka, Ituro Inoue BMC Genomics 2013, 14:355 (28 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

1470
Accesses

Research article   Open Access Highly Accessed

Characterization of human plasma-derived exosomal RNAs by deep sequencing

Xiaoyi Huang, Tiezheng Yuan, Michael Tschannen, Zhifu Sun, Howard Jacob, Meijun Du, Meihua Liang, Rachel L Dittmar, Yong Liu, Mingyu Liang, Manish Kohli, Stephen N Thibodeau, Lisa Boardman, Liang Wang BMC Genomics 2013, 14:319 (10 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

1460
Accesses

Research article   Open Access Highly Accessed

Tomato breeding in the genomics era: insights from a SNP array

Marcela Víquez-Zamora, Ben Vosman, Henri van de Geest, Arnaud Bovy, Richard GF Visser, Richard Finkers, Adriaan W van Heusden BMC Genomics 2013, 14:354 (27 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

1404
Accesses

Research article   Open Access Highly Accessed

Insights into organ-specific pathogen defense responses in plants: RNA-seq analysis of potato tuber-Phytophthora infestans interactions

Liangliang Gao, Zheng Tu, Benjamin P Millett, James M Bradeen BMC Genomics 2013, 14:340 (23 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

1265
Accesses

Research article   Open Access Highly Accessed

Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing

Robert Pinard, Alex de Winter, Gary J Sarkis, Mark B Gerstein, Karrie R Tartaro, Ramona N Plant, Michael Egholm, Jonathan M Rothberg, John H Leamon BMC Genomics 2006, 7:216 (23 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

11.

1252
Accesses

Research article   Open Access Highly Accessed

Identification of miRNAs associated with sexual maturity in chicken ovary by Illumina small RNA deep sequencing

Li Kang, Xinxing Cui, Yujie Zhang, Chunhong Yang, Yunliang Jiang BMC Genomics 2013, 14:352 (26 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Using a small RNA deep sequencing method on sexually immature and mature chicken ovaries differentially expressed miRNAs were identified and validated, including gga-miR-1a and gga-miR-21 thereby indicating a role in the follicular growth or ovulation mechanism.

12.

1249
Accesses

Research article   Open Access Highly Accessed

RNA-seq analysis of single bovine blastocysts

James L Chitwood, Gonzalo Rincon, German G Kaiser, Juan F Medrano, Pablo J Ross BMC Genomics 2013, 14:350 (25 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

1177
Accesses

Research article   Open Access Highly Accessed

RNA-seq analysis reveals extensive transcriptional plasticity to temperature stress in a freshwater fish species

Steve Smith, Louis Bernatchez, Luciano B Beheregaray BMC Genomics 2013, 14:375 (5 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

14.

1162
Accesses

Research article   Open Access Highly Accessed

Drosophila GAGA factor polyglutamine domains exhibit prion-like behavior

Muhammad Tariq, Renee Wegrzyn, Saima Anwar, Bernd Bukau, Renato Paro BMC Genomics 2013, 14:374 (3 June 2013)

Abstract | Provisional PDF | PubMed

15.

1158
Accesses

Research article   Open Access Highly Accessed

Draft genome sequence of the rubber tree Hevea brasiliensis

Ahmad Yamin Abdul Rahman, Abhilash O Usharraj, Biswapriya B Misra, Gincy P Thottathil, Kandakumar Jayasekaran, Yun Feng, Shaobin Hou, Su Yean Ong, Fui Ling Ng, Ling Sze Lee, Hock Siew Tan, Muhd Khairul Luqman Muhd Sakaff, Beng Soon Teh, Bee Khoo, Siti Suriawati Badai, Nurohaida Ab Aziz, Anton Yuryev, Bjarne Knudsen, Alexandre Dionne-Laporte, Nokuthula P Mchunu, Qingyi Yu, Brennick J Langston, Tracey Allen K Freitas, Aaron G Young, Rui Chen, Lei Wang, Nazalan Najimudin, Jennifer A Saito, Maqsudul Alam BMC Genomics 2013, 14:75 (2 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The draft genome of the rubber tree Hevea brasiliensis is almost 80% repetitive DNA with 12.7% of genes models identified being unique to this species, including key rubber biosynthesis and disease resistance genes

16.

1124
Accesses

Methodology article   Open Access Highly Accessed

NEXT-peak: a normal-exponential two-peak model for peak-calling in ChIP-seq data

Nak-Kyeong Kim, Rasika V Jayatillake, John L Spouge BMC Genomics 2013, 14:349 (25 May 2013)

Abstract | Full text | PDF | PubMed

17.

1087
Accesses

Research article   Open Access

Genome-scale transcriptional analyses of first-generation interspecific sunflower hybrids reveals broad regulatory compatibility

Heather C Rowe, Loren H Rieseberg BMC Genomics 2013, 14:342 (23 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

18.

1087
Accesses

Research article   Open Access Highly Accessed

Detection and genotyping of restriction fragment associated polymorphisms in polyploid crops with a pseudo-reference sequence: a case study in allotetraploid Brassica napus

Xun Chen, Xuemin Li, Bing Zhang, Jinsong Xu, Zhikun Wu, Bo Wang, Haitao Li, Muhammad Younas, Lei Huang, Yingfeng Luo, Jiangsheng Wu, Songnian Hu, Kede Liu BMC Genomics 2013, 14:346 (24 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

19.

1055
Accesses

Research article   Open Access Highly Accessed

Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

Li Chen, Qun Yue, Xinyu Zhang, Meichun Xiang, Chengshu Wang, Shaojie Li, Yongsheng Che, Francisco Ortiz-López, Gerald F Bills, Xingzhong Liu, Zhiqiang An BMC Genomics 2013, 14:339 (20 May 2013)

Abstract | Full text | PDF | PubMed

20.

1038
Accesses

Research article   Open Access

Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection

Sheila Z Kimaro Mlacha, Teresa C T Peret, Nikhil Kumar, Sandra Romero-Steiner, Julie C Dunning Hotopp, Nadeeza Ishmael, Valerie Grinblat-Huse, David R Riley, Dean D Erdman, George M Carlone, Jacquelyn Sampson, J Anthony G Scott, Hervé Tettelin BMC Genomics 2013, 14:378 (7 June 2013)

Abstract | Full text | PDF | PubMed

21.

1030
Accesses

Research article   Open Access

Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment

Ryan Y Wong, Sarah E Oxendine, John Godwin BMC Genomics 2013, 14:348 (24 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

22.

984
Accesses

Research article   Open Access Highly Accessed

The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and a comparison with the bark beetle-associated pine pathogen Grosmannia clavigera

Sajeet Haridas, Ye Wang, Lynette Lim, Sepideh Massoumi Alamouti, Shaun Jackman, Rod Docking, Gordon Robertson, Inanc Birol, Jörg Bohlmann, Colette Breuil BMC Genomics 2013, 14:373 (2 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

23.

973
Accesses

Methodology article   Open Access Highly Accessed

A simple and reproducible breast cancer prognostic test

Luigi Marchionni, Bahman Afsari, Donald Geman, Jeffrey T Leek BMC Genomics 2013, 14:336 (17 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

24.

961
Accesses

Research article   Open Access Highly Accessed

Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor

Franc Llorens, Manuela Hummel, Lorena Pantano, Xavier Pastor, Ana Vivancos, Ester Castillo, Heidi Mattlin, Anna Ferrer, Matthew Ingham, Marc Noguera, Robert Kofler, Juliane C Dohm, Raquel Pluvinet, Mònica Bayés, Heinz Himmelbauer, José del Rio, Eulàlia Martí, Lauro Sumoy BMC Genomics 2013, 14:371 (1 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

25.

941
Accesses

Research article   Open Access Highly Accessed

RAD tag sequencing as a source of SNP markers in Cynara cardunculus L

Davide Scaglione, Alberto Acquadro, Ezio Portis, Matteo Tirone, Steven J Knapp, Sergio Lanteri BMC Genomics 2012, 13:3 (3 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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