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The Role of Fbxw7 in the Inversed Expression Pattern between CD44v and c-Myc (Go Yoshida, 04 August 2014)

CD44 variant isoform (CD44v) is widely recognized to be a functional cancer stem cell marker to reduce reactive oxygen species. The inversed pattern was firstly identified in the normal gastric mucosa as well as tumor xenograft model. CD44v8-10(+) cells do not easily activate canonical Wnt signaling pathway as CD44v8-10(-) cells, which is why GRHL2-ESRP1-CD44v-xCT-GSH (glutathione) axis is regarded to be critical to repress the up-regulation of proto-oncogenic molecules such as c-Myc. Tumor tissue at the invasive area is considered to be composed of heterogeneous cellular population; dormant cancer stem-like cells with CD44v8-10 high/ Fbw7 high/ c-Myc low and proliferative cancer stem-like cells with CD44v8-10 high/ Fbw7 low/ c-Myc... read full comment

Comment on: Calcagno et al. BMC Gastroenterology, 13:141

IgG levels to food correlate with nutritional exposure to food antigens but a methodological weakness of this research prevents the recognition of Yeast-related foods as a possible cause of Irritable Bowel Syndrome (IBS). (Attilio Francesco Speciani, 20 February 2014)

Dear... read full comment

Comment on: Ligaarden et al. BMC Gastroenterology, 12:166

Link to Blog Mention of this Paper (George Henderson, 11 June 2013)

This paper seems well-designed, the analysis is insightful and the data is presented clearly; the results are so interesting I blogged about it here: read full comment

Comment on: Yakoot et al. BMC Gastroenterology, 12:32

Is there a linear relationship between increasing WC and incidence of Colonic Adenomas? (Raheem Dhanani, 23 March 2009)

A nicely written paper. It could have been more interesting if the association of having Colonic Adenomas could have been compared with increasing width of Wasit Cirumference (WC). Larsson and Wolk (1) demonstrated an increased risk of Colonic Ca with increasing WC (per 10 cm increase)in both sexes.

Despite the limitations mentioned in the current study, it may have given another dimension to the results.

1. Am J Clin Nutr, 2007 Sep;86(3):556-65 read full comment

Comment on: Kim et al. BMC Gastroenterology, 9:4

Confusion in the interpretation of CD4 among AIDS or HIV +ve patients (Hassan H. Dib, 23 January 2009)

It came to my attention while I am reviewing some papers on CD4 among HIV patients with Cryptosporidium, I have found your article and after reviewing it I have had found something a bit confusing. First, in your method you have mentioned that you have measured the levels of CD4 among HIV positive patients, and later then in your tables you have indicated that those reflect AIDS patients. Wouldn't CD4 levels will be totally different between HIV positive and AIDS patients who attracted Cryptosporidium. Plus, wouldn't AIDS patients have a higher tendency than HIV positive patietns to attract opportunisitc infections which will reflect proportionally on the CD4 levels between the two. read full comment

Comment on: Tuli et al. BMC Gastroenterology, 8:36

Oncological terrain plays a paramount role in the war against cancer-. (Sergio Stagnaro, 30 October 2004)

Sirs,I agry with paper's authors, but from the clinical view-point ( Hereditary risk factors for the development of gastric cancer in younger patients. Mohammad Yaghoobi , Nasser Rakhshani , Farhad Sadr , Raheleh Bijarchi , Yassamin Joshaghani , Ashraf Mohammadkhani , Arezu Attari , Mohammad reza Akbari , Mahshid Hormazdi and Reza Malekzadeh BMC Gastroenterology 2004, 4:28 doi:10.1186/1471-230X-4-28. Really in the war against cancers, we must especially study a clinical tool that helps “all” doctors in bed side recognizing, in apparently healthy individuals, genetical errors, including hyperinsulinemia-insulinresistance, melatonine deficiency, metabolic disorders, prevalence of stress axis, a.s.o., which either bring about or aggravate environmental chromosomal... read full comment

Comment on: Yaghoobi et al. BMC Gastroenterology, 4:28