BMC Evolutionary Biology

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Volume 2 (2002) - October 2002

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Research article   Open Access

Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation

J Arjan GM de Visser, Richard E Lenski BMC Evolutionary Biology 2002, 2:19 (30 October 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Early incorporation of the major mutations that provide the greatest gains in fitness accounts for the deceleration in the rate of fitness improvement observed during experimental evolution of E. coli over 20,000 generations.

Research article   Open Access

Birth and death of protein domains: A simple model of evolution explains power law behavior

Georgy P Karev, Yuri I Wolf, Andrey Y Rzhetsky, Faina S Berezovskaya, Eugene V Koonin BMC Evolutionary Biology 2002, 2:18 (14 October 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A simple model of evolution of the domain composition of proteins which includes domain birth, death and innovation, but not explicitly selection, can explain the observed power law distribution of domain family size.