Image highlight - July 2009

Undersized eye of zebrafish embryo with a mutated condensin gene. The condensin I protein CAP-G, which functions in chromosome condensation and segregation, is encoded by the creature from the black lagoon (cbl) locus in Zebrafish, and embryos bearing a mutant allele of this locus (cbl^s105) show mitotic defects and a severe size reduction of the retina and head compared with wild-type embryos. Mutant embryos at 3 days post fertilization still have the three layers of the eye containing differentiated cells (ganglion; amacrine, bipolar and horizontal cells, and photoreceptor cells in the outermost layer) but the number of retinal cells are reduced by half compared with wild-type eyes. Transverse sections through the retinae were stained with phalloidin (to visualise the plexiform layers of differentiating cells: red) and propidium iodide to mark nuclei (green) with a little overlap of signal in yellow.

Taken from: S. Seipold et al. BMC Developmental Biology 2009, 9:40 [View article]

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