Loss of S1P1R causes altered cardiac morphologySphingosine-1-Phospate Receptor 1 (S1P1R) is a cell surface receptor for sphingosine-1-phosophate (S1P) involved in cellular events such as differentiation, proliferation, and migration. Embryonic hearts, from S1P1R knockout mice, at E12.5 stage demonstrates disrupted morphology, including rounded apex, reduced ventricular tissue and disorganized compact layer and trabeculae. Image shows E12.5 saggital heart sections immunostained for sarcomeric α-actin (green) and propidium iodide (red) to mark the nuclei.
Taken from: Christopher Wendler et al., 2011, BMC Developmental Biology [View article]
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