Tenascin-C accumulates at the border zone between the myocardium and fibrotic tissue
Tenascin-C accumulates at the border zone between the myocardium and fibrotic tissue Heart infarction in zebrafish results in the formation of extensive scar tissue with conspicuous accumulation of de-adhesive protein Tenascin-C (green) at the border zone between the intact myocardium and the injury site. Within one to two months after heart injury, new cardiomyocytes invade the post-infarct area and progressively replace the scar. Transversal section of the ventricle at 14 days post cryoinjury was immunostained with antibody against Tropomyosin (purple) to label myocardium, and Tenascin-C (green) to visualize tissue-remodeling protein.
Taken from: Anna Jazwinska et al., 2011, BMC Developmental Biology [View article]