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Blimp1 as a sebaceous gland stem cell marker; Crosstalk with TGF-beta signal (Go Yoshida, 23 July 2014)

It has recently been reported that Blimp1 is a functional stem cell marker for sebaceous glands. Blimp1 suppresses the transcription level of c-Myc, thereby inducing the quiescence of stem cells (Cell. 2006;126:597-609.). It is possible that TGF-beta signaling pathway is associated with Blimp1, leading to maintain the stemness of sebaceous gland cells.
However, I failed to demonstrate the heterogeneity of Blimp1 expression in the xenograft/ organoid formation as well as in three-dimensional (3D) culture of SZ95 cells, one of the immortalized sebaceous gland cells. Instead, there was the heterogeneity in the expression of Wnt/beta-catenin signal activity only after 3D culture, but not in 2D culture (Biochem Biophys Res Commun. 2013 Sep 6;438(4):640-6.). read full comment

Comment on: McNairn et al. BMC Dermatology, 13:2

Labelling errors in Table 1 and text (Name Withheld, 24 June 2014)

Readers should be aware that are labelling errors in Table 1, and in the text accompanying the description thereof. The table is based on the paper by Reich et al., which presented the results for a network meta-analysis (NMA). As the NMA used a Bayesian approach, the results in Table 1 represents the estimated probabilities for response (not mean % of patients who respond) and correspondening 95% Credible Intervals (not confidence intervals). It would have been more accurate for Table 1 to be written with the labels as per the Reich et al. publication , and for the text to mention that it was a NMA that used a Baysian approach (as apposed to a frequentist approach). read full comment

Comment on: Avgerinou et al. BMC Dermatology, 12:10

An important yet contraversial finding (Farzam Gorouhi, 17 September 2007)

I think this paper would help us to further document the contraversial relationship between acne and smoking although it has not yet established or rejected. A prognostic systematic review has to be done in order to evaluate this correlation. read full comment

Comment on: Firooz et al. BMC Dermatology, 5:2

An important yet contraversial finding (Farzam Gorouhi, 06 September 2007)

I think this paper would help us to further document the contraversial relationship between acne and smoking although it has not yet established or rejected. A prognostic systematic review has to be done in order to evsluate this correlation. read full comment

Comment on: Firooz et al. BMC Dermatology, 5:2