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1.

1894
Accesses

Research article   Open Access Highly Accessed

Unique immunologic patterns in fibromyalgia

Frederick G Behm, Igor M Gavin, Oleksiy Karpenko, Valerie Lindgren, Sujata Gaitonde, Peter A Gashkoff, Bruce S Gillis BMC Clinical Pathology 2012, 12:25 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cytokine levels in stimulated blood cells taken from patients suffering from the chronic pain and fatigue syndrome fibromyalgia were significantly lower than in cells taken from healthy controls, offering a potential diagnostic test for this disease

2.

620
Accesses

Research article   Open Access Highly Accessed

Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting

Bernard Nkrumah, Samuel Nguah, Nimako Sarpong, Denise Dekker, Ali Idriss, Juergen May, Yaw Adu-Sarkodie BMC Clinical Pathology 2011, 11:5 (21 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

594
Accesses

Research article   Open Access

Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years

Liang Chen, Xiang Zou, Yin Wang, Ying Mao, Liangfu Zhou BMC Clinical Pathology 2013, 13:14 (2 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The number of central nerve system tumors treated at a single center in China has increased substantially over the last 60 years, with lymphoma and hematopoietic neoplasm cases particularly high

4.

584
Accesses

Research article   Open Access Highly Accessed

Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem

Carolyn D Rysgaard, Cory S Morris, Denny Drees, Tami Bebber, Scott R Davis, Jeff Kulhavy, Matthew D Krasowski BMC Clinical Pathology 2012, 12:15 (24 September 2012)

Abstract | Full text | PDF | PubMed

5.

517
Accesses

Technical advance   Open Access

Comparison of automated and manual FISH for evaluation of HER2 gene status on breast carcinoma core biopsies

Christian Öhlschlegel, Doris Kradolfer, Margreth Hell, Wolfram Jochum BMC Clinical Pathology 2013, 13:13 (20 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Automated FISH evaluation of HER2 gene status has a strong concordance with the traditional manual method, providing a quicker and more efficient method to assess the suitability of trastuzumab in treating breast cancer patients

6.

484
Accesses

Case report   Open Access Highly Accessed

Rosai-Dorfman Disease: A previously unreported association with Sickle Cell Disease

Claire Stebbing, Jon van der Walt, Ghada Ramadan, Baba Inusa BMC Clinical Pathology 2007, 7:3 (2 April 2007)

Abstract | Full text | PDF | PubMed

7.

382
Accesses

Research article   Open Access

Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors

Saadia A Aziz, Joshua A Sznol, Adebowale Adeniran, Fabio Parisi, Yuval Kluger, Robert L Camp, Harriet M Kluger BMC Clinical Pathology 2013, 13:3 (1 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Expression levels of most common drug targets are the same in both primary and metastatic renal carcinoma tumors, meaning that biomarker tests could be used on either tumor type

8.

343
Accesses

Research article   Open Access Highly Accessed

Comparison of haematological parameters determined by the Sysmex KX - 2IN automated haematology analyzer and the manual counts

Samuel O Ike, Thomas Nubila, Ernest O Ukaejiofo, Imelda N Nubila, Elvis N Shu, Ifeyinwa Ezema BMC Clinical Pathology 2010, 10:3 (23 April 2010)

Abstract | Full text | PDF | PubMed

9.

261
Accesses

Research article   Open Access Highly Accessed

Effects of different centrifugation conditions on clinical chemistry and Immunology test results

Elisabeth I Minder, Adrian Schibli, Dagmar Mahrer, Predrag Nesic, Kathrin Plüer BMC Clinical Pathology 2011, 11:6 (10 May 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Centrifuging heparinized blood samples for either seven minutes at 1870g or ten minutes at 2180g provides identical test results compared to those centrifuged under the same conditions for fifteen minutes as proposed by WHO.

10.

251
Accesses

Research article   Open Access

Cervical lymph node metastases from thyroid cancer: does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology?

Enke Baldini, Salvatore Sorrenti, Cira Di Gioia, Corrado De Vito, Alessandro Antonelli, Lucio Gnessi, Giovanni Carbotta, Eleonora D’Armiento, Paolo Miccoli, Enrico De Antoni, Salvatore Ulisse BMC Clinical Pathology 2013, 13:7 (19 February 2013)

Abstract | Full text | PDF | PubMed

11.

241
Accesses

Research article   Open Access Highly Accessed

Cortisol in hair measured in young adults - a biomarker of major life stressors?

Jerker Karlén, Johnny Ludvigsson, Anneli Frostell, Elvar Theodorsson, Tomas Faresjö BMC Clinical Pathology 2011, 11:12 (25 October 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Increased cortisol levels in hair may serve as a biomarker of increased cortisol production reflecting exposure to major life stressors or extended physiological illness, with serious life events potentially raising hair hormone levels more than perceived stress.

12.

226
Accesses

Research article   Open Access

Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis

Pramodh C Chandrasinghe, Dileepa S Ediriweera, Sumudu K Kumarage, Kemal I Deen BMC Clinical Pathology 2013, 13:12 (16 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

220
Accesses

Research article   Open Access

A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer

Takayuki Kobayashi, Keiichi Iwaya, Tomoyuki Moriya, Tamio Yamasaki, Hitoshi Tsuda, Junji Yamamoto, Osamu Matsubara BMC Clinical Pathology 2013, 13:5 (6 February 2013)

Abstract | Full text | PDF | PubMed

14.

209
Accesses

Technical advance   Open Access

Touchdown General Primer (GP5+/GP6+) PCR and optimized sample DNA concentration support the sensitive detection of human papillomavirus

Mark F Evans, Christine SC Adamson, Linda Simmons-Arnold, Kumarasen Cooper BMC Clinical Pathology 2005, 5:10 (16 November 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

189
Accesses

Research article   Open Access

Quantification of fractal dimension and Shannon’s entropy in histological diagnosis of prostate cancer

Pedro Francisco Ferraz de Arruda, Márcio Gatti, Fernando Nestor Facio Junior, José Germano Ferraz de Arruda, Roberto Douglas Moreira, Luiz Otávio Murta, Laísa Ferraz de Arruda, Moacir Fernandes de Godoy BMC Clinical Pathology 2013, 13:6 (18 February 2013)

Abstract | Full text | PDF | PubMed

16.

181
Accesses

Research article   Open Access Highly Accessed

Effects of EDTA and Sodium Citrate on hormone measurements by fluorometric (FIA) and immunofluorometric (IFMA) methods

Maria Kohek, Cassia Leme, Izabel T Nakamura, Suzimara A de Oliveira, Valeria Lando, Berenice B Mendonca BMC Clinical Pathology 2002, 2:2 (23 May 2002)

Abstract | Full text | PDF | PubMed

17.

170
Accesses

Research article   Open Access

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case–control study

Qian Xu, Qi-Guan Dong, Li-ping Sun, Cai-yun He, Yuan Yuan BMC Clinical Pathology 2013, 13:11 (22 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

18.

169
Accesses

Case report   Open Access Highly Accessed

An unusual cause of granulomatous disease

Andrew PC Mclean-Tooke, Catherine Aldridge, Kimberley Gilmour, Bernard Higgins, Mark Hudson, Gavin P Spickett BMC Clinical Pathology 2007, 7:1 (2 March 2007)

Abstract | Full text | PDF | PubMed

19.

163
Accesses

Research article   Open Access Highly Accessed

The combined positive impact of Lean methodology and Ventana Symphony autostainer on histology lab workflow

Lewis A Hassell, Crystal F Glass, Clinton Yip, Patricia A Eneff BMC Clinical Pathology 2010, 10:2 (8 February 2010)

Abstract | Full text | PDF | PubMed

20.

159
Accesses

Technical advance   Open Access

Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy

Colin A Hutchison, Paul Cockwell, Mark Cook BMC Clinical Pathology 2012, 12:12 (9 August 2012)

Abstract | Full text | PDF | PubMed

21.

157
Accesses

Research article   Open Access

Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast

Nuran Serce, Annette Gnatzy, Susanne Steiner, Henning Lorenzen, Jutta Kirfel, Reinhard Buettner BMC Clinical Pathology 2012, 12:13 (24 August 2012)

Abstract | Full text | PDF | PubMed

22.

153
Accesses

Research article   Open Access Highly Accessed

Real-time PCR complements immunohistochemistry in the determination of HER-2/neu status in breast cancer

Andreea Nistor, Peter H Watson, Norman Pettigrew, Karim Tabiti, Angelika Dawson, Yvonne Myal BMC Clinical Pathology 2006, 6:2 (18 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A real-time polymerase chain reaction test for determining the status of Her-s/neu amplification in breast cancer is comparable to fluorescent in-situ hybridization in cases found where the standard immunohistochemical method is indeterminate.

23.

146
Accesses

Research article   Open Access

Expression profiling of 21 biomolecules in locally advanced nasopharyngeal carcinomas of Caucasian patients

Dimitrios Krikelis, Mattheos Bobos, Georgia Karayannopoulou, Liliana Resiga, Sofia Chrysafi, Epaminontas Samantas, Dimitrios Andreopoulos, Vassilios Vassiliou, Elisabeta Ciuleanu, George Fountzilas BMC Clinical Pathology 2013, 13:1 (29 January 2013)

Abstract | Full text | PDF | PubMed

24.

145
Accesses

Research article   Open Access Highly Accessed

Derivation and internal validation of an equation for albumin-adjusted calcium

Matthew T James, Jianguo Zhang, Andrew W Lyon, Brenda R Hemmelgarn BMC Clinical Pathology 2008, 8:12 (27 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

143
Accesses

Research article   Open Access

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Juho Konsti, Mikael Lundin, Heikki Joensuu, Tiina Lehtimäki, Harri Sihto, Kaija Holli, Taina Turpeenniemi-Hujanen, Vesa Kataja, Liisa Sailas, Jorma Isola, Johan Lundin BMC Clinical Pathology 2011, 11:3 (25 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An automated analysis of Ki-67 expression run on a virtual microscopy platform in breast cancer samples is comparable to visual assessment, and is a significant and independent predictor of outcome.

26.

142
Accesses

Research article   Open Access Highly Accessed

External quality assurance as a revalidation method for pathologists in pediatric histopathology: Comparison of four international programs

Consolato Sergi, Gregor Mikuz BMC Clinical Pathology 2008, 8:11 (12 November 2008)

Abstract | Full text | PDF | PubMed

27.

140
Accesses

Research article   Open Access Highly Accessed

Gender dimorphism in differential peripheral blood leukocyte counts in mice using cardiac, tail, foot, and saphenous vein puncture methods

Diana C Doeing, Jessica L Borowicz, Elahé T Crockett BMC Clinical Pathology 2003, 3:3 (12 September 2003)

Abstract | Full text | PDF | PubMed

28.

134
Accesses

Research article   Open Access

Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status

Eyad M Mallah, Mohammad F Hamad, Mays A ElManaseer, Nidal A Qinna, Nasir M Idkaidek, Tawfiq A Arafat, Khalid Z Matalka BMC Clinical Pathology 2011, 11:8 (4 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

133
Accesses

Research article   Open Access

Factors associated with serum CA19-9 levels among healthy children: a cross-sectional study

Sayo Kawai, Sueli M Oba-Shinjo, Lucy S Ito, Miyuki Uno, Suely K N Marie, Nobuyuki Hamajima BMC Clinical Pathology 2012, 12:23 (4 December 2012)

Abstract | Full text | PDF | PubMed

30.

131
Accesses

Case report   Open Access Highly Accessed

Persistence of Natural Killer (NK) cell lymphocytosis with hyposplenism without development of leukaemia

Sujoy Khan, K Myers BMC Clinical Pathology 2005, 5:8 (7 September 2005)

Abstract | Full text | PDF | PubMed

31.

126
Accesses

Research article   Open Access Highly Accessed

Histopathological evaluation of ocular microsporidiosis by different stains

Joveeta Joseph, Geeta K Vemuganti, Prashant Garg, Savitri Sharma BMC Clinical Pathology 2006, 6:6 (23 June 2006)

Abstract | Full text | PDF | PubMed

32.

123
Accesses

Research article   Open Access

Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma*

Thaer Khoury, Dongfeng Tan, Jianmin Wang, Marilyn Intengan, Jun Yang, Sadir Alrawi, Peisha Yan, James C Byrd BMC Clinical Pathology 2006, 6:1 (12 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

123
Accesses

Research article   Open Access Highly Accessed

The calcium-binding protein S100P in normal and malignant human tissues

Seppo Parkkila, Pei-wen Pan, Aoife Ward, Adriana Gibadulinova, Ingrid Oveckova, Silvia Pastorekova, Jaromir Pastorek, Alejandra Martinez, Henrik O Helin, Jorma Isola BMC Clinical Pathology 2008, 8:2 (18 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

122
Accesses

Research article   Open Access Highly Accessed

A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay

Marilena Kampa, Anastasia Nistikaki, Vassilios Tsaousis, Niki Maliaraki, George Notas, Elias Castanas BMC Clinical Pathology 2002, 2:3 (28 August 2002)

Abstract | Full text | PDF | PubMed

35.

122
Accesses

Research article   Open Access

Triple-negative breast cancer is associated with EGFR, CK5/6 and c-KIT expression in Malaysian women

Shant Kanapathy Pillai, Annie Tay, Suseela Nair, Chee-Onn Leong BMC Clinical Pathology 2012, 12:18 (26 September 2012)

Abstract | Full text | PDF | PubMed

36.

120
Accesses

Research article   Open Access

Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia

Arsen Arakelyan, Roksana Zakharyan, Aren Khoyetsyan, David Poghosyan, Rouben Aroutiounian, Frantisek Mrazek, Martin Petrek, Anna Boyajyan BMC Clinical Pathology 2011, 11:10 (25 August 2011)

Abstract | Full text | PDF | PubMed

37.

119
Accesses

Technical advance   Open Access Highly Accessed

COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

Colin C Pritchard, Laura Akagi, Poluru L Reddy, Loren Joseph, Jonathan F Tait BMC Clinical Pathology 2010, 10:6 (26 November 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The COLD-PCR enhanced melting curve assay can detect down to 1% KRAS-mutant alleles in a wild type background and significantly improves diagnostic accuracy compared to traditional PCR and direct sequencing.

38.

119
Accesses

Research article   Open Access

Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

Eliana Bignotti, Laura Zanotti, Stefano Calza, Marcella Falchetti, Silvia Lonardi, Antonella Ravaggi, Chiara Romani, Paola Todeschini, Elisabetta Bandiera, Renata A Tassi, Fabio Facchetti, Enrico Sartori, Sergio Pecorelli, Dana M Roque, Alessandro D Santin BMC Clinical Pathology 2012, 12:22 (14 November 2012)

Abstract | Full text | PDF | PubMed

39.

119
Accesses

Research article   Open Access Highly Accessed

Immunophenotypic studies of monoclonal gammopathy of undetermined significance

Horatiu Olteanu, Huan-You Wang, Weina Chen, Robert W McKenna, Nitin J Karandikar BMC Clinical Pathology 2008, 8:13 (28 November 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients with monoclonal gammopathy of undetermined significance that display a higher proportion of CD19(+) plasma cells are potentially less likely to progress to plasma cell myeloma.

40.

114
Accesses

Research article   Open Access Highly Accessed

Validation of human papillomavirus genotyping by signature DNA sequence analysis

Sin Lee, Veronica S Vigliotti, Jessica S Vigliotti, Suri Pappu BMC Clinical Pathology 2009, 9:3 (22 May 2009)

Abstract | Full text | PDF | PubMed

41.

116
Accesses

Technical advance   Open Access Highly Accessed

Primary histologic diagnosis using automated whole slide imaging: a validation study

John R Gilbertson, Jonhan Ho, Leslie Anthony, Drazen M Jukic, Yukako Yagi, Anil V Parwani BMC Clinical Pathology 2006, 6:4 (27 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

42.

114
Accesses

Research article   Open Access

Iron status in HIV-1 infection: implications in disease pathology

S Olatunbosun Banjoko, Falilat A Oseni, Rachel A Togun, Olaniyi Onayemi, Beatrice O Emma-Okon, Julius B Fakunle BMC Clinical Pathology 2012, 12:26 (17 December 2012)

Abstract | Full text | PDF | PubMed

43.

114
Accesses

Case report   Open Access Highly Accessed

Lymph node infarction – a rare complication associated with disseminated intra vascular coagulation in a case of dengue fever

I Satish Rao, Anand C Loya, KS Ratnakar, VR Srinivasan BMC Clinical Pathology 2005, 5:11 (12 December 2005)

Abstract | Full text | PDF | PubMed

44.

113
Accesses

Research article   Open Access

Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study

Shweta Ujaoney, Mukta B Motwani, Shirish Degwekar, Vijay Wadhwan, Prajakta Zade, Minal Chaudhary, Vinay Hazarey, Tushar P Thakre, Manju Mamtani BMC Clinical Pathology 2012, 12:6 (12 March 2012)

Abstract | Full text | PDF | PubMed

45.

110
Accesses

Research article   Open Access

A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps

Matthew D Krasowski, Rebecca M Wilcoxon, Joel Miron BMC Clinical Pathology 2012, 12:1 (12 January 2012)

Abstract | Full text | PDF | PubMed

46.

111
Accesses

Research article   Open Access Highly Accessed

Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

Sveinung W Sorbye, Thomas K Kilvaer, Andrej Valkov, Tom Donnem, Eivind Smeland, Khalid Al-Shibli, Roy M Bremnes, Lill-Tove Busund BMC Clinical Pathology 2012, 12:7 (3 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Increased co-expression of M-CSF and TGF-beta in soft tissue sarcoma, and increased expression of Ki67 in peritumoral capsule are independent negative prognostic factors for survival, suggesting that innate immunity markers may serve as prognosticators in soft tissue sarcomas.

47.

110
Accesses

Research article   Open Access Highly Accessed

Infrared micro-spectral imaging: distinction of tissue types in axillary lymph node histology

Benjamin Bird, Milos Miljkovic, Melissa J Romeo, Jennifer Smith, Nicholas Stone, Michael W George, Max Diem BMC Clinical Pathology 2008, 8:8 (29 August 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Diagnosis of breast cancer may be automated and improved by imaging using Fourier transform infrared micro-spectroscopy and multivariate analysis in place of conventional histology on axillary lymph node tissue.

48.

108
Accesses

Technical advance   Open Access Highly Accessed

Conventional liquid-based techniques versus Cytyc Thinprep® processing of urinary samples: a qualitative approach

Eric Piaton, Jacqueline Faÿnel, Karine Hutin, Marie-Claude Ranchin, Michèle Cottier BMC Clinical Pathology 2005, 5:9 (6 October 2005)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A qualitative comparison of various methods of obtaining thin layer cytologic preparations from urine revealed cytocentrifugation with disposable chambers to be the most appropriate method overall.

49.

107
Accesses

Research article   Open Access Highly Accessed

Types and frequency of preanalytical mistakes in the first Thai ISO 9002:1994 certified clinical laboratory, a 6 – month monitoring

Viroj Wiwanitkit BMC Clinical Pathology 2001, 1:5 (16 October 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

107
Accesses

Research article   Open Access Highly Accessed

Testing for hereditary thrombophilia: a retrospective analysis of testing referred to a national laboratory

Brian R Jackson, Kyland Holmes, Amit Phansalkar, George M Rodgers BMC Clinical Pathology 2008, 8:3 (2 April 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Clinical tests ordered by physicians for inherited thrombophilia are generally not in line with recommended guidelines from the College of American Pathologists, indicating that better dissemination of these guidelines are needed.

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