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Research article   Open Access Highly Accessed

Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting

Bernard Nkrumah, Samuel Nguah, Nimako Sarpong, Denise Dekker, Ali Idriss, Juergen May, Yaw Adu-Sarkodie BMC Clinical Pathology 2011, 11:5 (21 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors

Mohamed S Ayoub, Houry M Baghdadi, Moataz El-Kholy BMC Clinical Pathology 2011, 11:4 (2 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Juho Konsti, Mikael Lundin, Heikki Joensuu, Tiina Lehtimäki, Harri Sihto, Kaija Holli, Taina Turpeenniemi-Hujanen, Vesa Kataja, Liisa Sailas, Jorma Isola, Johan Lundin BMC Clinical Pathology 2011, 11:3 (25 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An automated analysis of Ki-67 expression run on a virtual microscopy platform in breast cancer samples is comparable to visual assessment, and is a significant and independent predictor of outcome.

Research article   Open Access

Differential effects of frozen storage on the molecular detection of bacterial taxa that inhabit the nasopharynx

Brenda A Kwambana, Nuredin I Mohammed, David Jeffries, Mike Barer, Richard A Adegbola, Martin Antonio BMC Clinical Pathology 2011, 11:2 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Immunohistochemical staining of radixin and moesin in prostatic adenocarcinoma

Tanner L Bartholow, Uma R Chandran, Michael J Becich, Anil V Parwani BMC Clinical Pathology 2011, 11:1 (14 January 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Radixin shows a lower expression level in prostatic adenocarcinoma and normal tissue adjacent to adenocarcinoma than other types of prostate tissue and it may have potential as a clinically useful biomarker.

Technical advance   Open Access Highly Accessed

COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

Colin C Pritchard, Laura Akagi, Poluru L Reddy, Loren Joseph, Jonathan F Tait BMC Clinical Pathology 2010, 10:6 (26 November 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The COLD-PCR enhanced melting curve assay can detect down to 1% KRAS-mutant alleles in a wild type background and significantly improves diagnostic accuracy compared to traditional PCR and direct sequencing.

Research article   Open Access

Use of the GenoType® MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda

Joel Bazira, Benon B Asiimwe, Moses L Joloba, Fred Bwanga, Mecky I Matee BMC Clinical Pathology 2010, 10:5 (6 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The GenoType(R) MTBDRplus assay detects low levels of resistance to antibiotics in tuberculosis patients in Uganda, indicating that this technique may be suitable for use in diagnostic laboratories in countries lacking the capacity to undertake drug susceptibility testing.

Research article   Open Access

Accumulation of advanced glycation end (AGEs) products in intensive care patients: an observational, prospective study

Wendela L Greven, Jitty M Smit, Johannes H Rommes, Peter E Spronk BMC Clinical Pathology 2010, 10:4 (25 May 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Comparison of haematological parameters determined by the Sysmex KX - 2IN automated haematology analyzer and the manual counts

Samuel O Ike, Thomas Nubila, Ernest O Ukaejiofo, Imelda N Nubila, Elvis N Shu, Ifeyinwa Ezema BMC Clinical Pathology 2010, 10:3 (23 April 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The combined positive impact of Lean methodology and Ventana Symphony autostainer on histology lab workflow

Lewis A Hassell, Crystal F Glass, Clinton Yip, Patricia A Eneff BMC Clinical Pathology 2010, 10:2 (8 February 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma

Joerg Schwock, Grace Bradley, James C Ho, Bayardo Perez-Ordonez, David W Hedley, Jonathan C Irish, William R Geddie BMC Clinical Pathology 2010, 10:1 (5 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The transcriptional repressor protein SNAI1 is expressed at low levels in a substantial proportion of oral squamous cell carcinomas, but high expression may be associated with a poor prognosis.

Research article   Open Access Highly Accessed

Immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients, Kampala, Uganda

Lynnette K Tumwine, Claudio Agostinelli, Cristina Campidelli, Emmanuel Othieno, Henry Wabinga, Simona Righi, Brunangelo Falini, Pier Piccaluga, Wilson Byarugaba, Stefano A Pileri BMC Clinical Pathology 2009, 9:11 (16 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Immunohistochemical subtyping of patients with B cell non-Hodgkin lymphoma in the resource-limited country Uganda showed that most have the clinically aggressive Burkitt lymphoma, and in these patients receiving chemotherapy is associated with good prognosis.

Research article   Open Access

Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements

Joshua S Davis, Christabelle J Darcy, Kim Piera, Yvette R McNeil, Tonia Woodberry, Nicholas M Anstey BMC Clinical Pathology 2009, 9:10 (27 November 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Arginine in whole blood samples at room temperature is rapidly degraded while taurine increases both at room temperature and on ice, so blood for amino acid analyses needs to be placed on ice or processed quickly after collection.

Research article   Open Access Highly Accessed

CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma

Ariel A Williams, John PT Higgins, Hongjuan Zhao, Börje Ljungberg, James D Brooks BMC Clinical Pathology 2009, 9:9 (18 November 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumor

Mats Jönsson, Anna Ekstrand, Thomas Edekling, Jakob Eberhard, Dorthe Grabau, David Borg, Mef Nilbert BMC Clinical Pathology 2009, 9:8 (15 October 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Matrix metalloproteinases in subjects with type 1 diabetes

Sedegheh Gharagozlian, Katja Svennevig, Hans-Jacob Bangstad, Jan-Olof Winberg, Svein Kolset BMC Clinical Pathology 2009, 9:7 (16 September 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Changes in serum levels and activity of matrix metalloproteinases (MMPs) in type I diabetes patients may correlate to early nephropathy, and are potentially useful as markers of people at risk of progression to chronic kidney disease.

Research article   Open Access

pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda

Sam Kalungi, Solrun J Steine, Henry Wabinga, Leif Bostad, Anders Molven BMC Clinical Pathology 2009, 9:6 (19 August 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mutations in the RBL2 gene, which encodes the retinoblastoma protein family cell cycle protein pRb2, were not detected in Burkitt lymphoma patients from Uganda, suggesting that RBL2 mutations may be rarer in this condition than previously suggested.

Research article   Open Access

Improved Methodology for Assessment of mRNA Levels in Blood of Patients with FMR1 Related Disorders

David E Godler, Danuta Z Loesch, Richard Huggins, Lavinia Gordon, Howard R Slater, Freya Gehling, Trent Burgess, KH Andy Choo BMC Clinical Pathology 2009, 9:5 (9 June 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Mitochondrial mosaics in the liver of 3 infants with mtDNA defects

Frank Roels, Patrick Verloo, François Eyskens, Baudouin François, Sara Seneca, Boel De Paepe, Jean-Jacques Martin, Valerie Meersschaut, Marleen Praet, Emmanuel Scalais, Marc Espeel, Joél Smet, Gert Van Goethem, Rudy Van Coster BMC Clinical Pathology 2009, 9:4 (5 June 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Validation of human papillomavirus genotyping by signature DNA sequence analysis

Sin Lee, Veronica S Vigliotti, Jessica S Vigliotti, Suri Pappu BMC Clinical Pathology 2009, 9:3 (22 May 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Performance of the Genotype® MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian Federation

Vladyslav Nikolayevskyy, Yanina Balabanova, Tatyana Simak, Nadezhda Malomanova, Ivan Fedorin, Francis Drobniewski BMC Clinical Pathology 2009, 9:2 (10 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The MTBDRplus assay system provides a suitable test for drug-resistant tuberculosis in sputum samples from patients in Samara, Russia, demonstrating high sensitivity and specificity and being more rapid than conventional laboratory tests.

Research article   Open Access Highly Accessed

Molecular analysis of Mycobacterium isolates from extrapulmonary specimens obtained from patients in Mexico

Cosme Alvarado-Esquivel, Nora García-Corral, David Carrero-Dominguez, José Enciso-Moreno, Teodoro Gurrola-Morales, Leopoldo Portillo-Gómez, Rudi Rossau, Wouter Mijs BMC Clinical Pathology 2009, 9:1 (9 March 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mycobacteria are found in a wide range of extrapulmonary tissues and body fluids in Mexican patients diagnosed with extrapulmonary tuberculosis, although most were non-tubercular and were sensitive to rifampacin.

Research article   Open Access Highly Accessed

Immunophenotypic studies of monoclonal gammopathy of undetermined significance

Horatiu Olteanu, Huan-You Wang, Weina Chen, Robert W McKenna, Nitin J Karandikar BMC Clinical Pathology 2008, 8:13 (28 November 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients with monoclonal gammopathy of undetermined significance that display a higher proportion of CD19(+) plasma cells are potentially less likely to progress to plasma cell myeloma.

Research article   Open Access Highly Accessed

Derivation and internal validation of an equation for albumin-adjusted calcium

Matthew T James, Jianguo Zhang, Andrew W Lyon, Brenda R Hemmelgarn BMC Clinical Pathology 2008, 8:12 (27 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

External quality assurance as a revalidation method for pathologists in pediatric histopathology: Comparison of four international programs

Consolato Sergi, Gregor Mikuz BMC Clinical Pathology 2008, 8:11 (12 November 2008)

Abstract | Full text | PDF | PubMed

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