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	1. 269 Accesses	Research article Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen Tong Shi, Ju Bao, Nick X Wang, Jie Zheng, Dianqing Wu BMC Chemical Biology 2012, 12:4 (14 May 2012) Abstract \| Provisional PDF \| PubMed
	2. 240 Accesses	Research article Chemical-genetic profile analysis of five inhibitory compounds in yeast Md Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi, Ashkan Golshani BMC Chemical Biology 2010, 10:6 (6 August 2010) Abstract \| Full text \| PDF \| PubMed
	3. 238 Accesses	Research article Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility Courtney R LaValle, Karla Bravo-Altamirano, Karthik V Giridhar, Jun Chen, Elizabeth Sharlow, John S Lazo, Peter Wipf, Q Jane Wang BMC Chemical Biology 2010, 10:5 (5 May 2010) Abstract \| Full text \| PDF \| PubMed
	4. 234 Accesses	Research article Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria Olofsson, Aleksandra Havelka, Slavica Brnjic, Maria C Shoshan, Stig Linder BMC Chemical Biology 2008, 8:2 (1 August 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Inducing apoptosis using compounds screened from a chemical library demonstrates that calcium signaling is generally not an early event and suggests that the calmodulin kinase II pathway is often important in sustaining apoptosis.
	5. 223 Accesses	Methodology article Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications Hiroki Kobayashi, Hiroko Harada, Masaomi Nakamura, Yushi Futamura, Akihiro Ito, Minoru Yoshida, Shun-ichiro Iemura, Kazuo Shin-ya, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Masaya Imoto, Yasubumi Sakakibara BMC Chemical Biology 2012, 12:2 (5 April 2012) Abstract \| Provisional PDF \| PubMed
	6. 208 Accesses	Methodology article Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites Fazlurrahman Khan, Dhan Prakash, RK Jain BMC Chemical Biology 2011, 11:2 (23 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A simple and rapid high performance liquid chromatography (HPLC) based method for the determination of polychlorinated fungicides such as PCNB, HCB and their possible intermediates provides good recovery, peak resolution and sensitivity without internal interference.
	7. 205 Accesses	Review The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds Nicolas Puillandre, Mandë Holford BMC Chemical Biology 2010, 10:7 (17 September 2010) Abstract \| Full text \| PDF \| PubMed
	8. 196 Accesses	Research article NAD⁺metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy, Charles Brenner BMC Chemical Biology 2010, 10:2 (22 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Quantifying the NAD+ metabolome in two different conditions that extend yeast lifespan indicates that NAD+ precursor vitamins and calorie restriction may extend lifespan by different mechanisms and that ratios of NAD+ metabolites may not underlie the mechanism of calorie restriction.
	9. 188 Accesses	Research article Covalent attachment of the plant natural product naringenin to small glass and ceramic beads Yuhua Lu, Niloufer G Irani, Erich Grotewold BMC Chemical Biology 2005, 5:3 (10 October 2005) Abstract \| Full text \| PDF \| PubMed
	10. 187 Accesses	Research article High toxicity and specificity of the saponin 3-GlcA-28-AraRhaxyl-medicagenate from Medicago truncatula seeds for Sitophilus oryzae Pedro DA SILVA, Vanessa Eyraud, Maïté Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer, Frederic Gressent BMC Chemical Biology 2012, 12:3 (26 April 2012) Abstract \| Provisional PDF \| PubMed
	11. 183 Accesses	Research article Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Chène, Joëlle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz, Thomas Radimerski BMC Chemical Biology 2009, 9:1 (7 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The discovery of a novel catalytic inhibitor of human topoisomerase II ATPase activity, quinonoline aminopurine compound 1 (QAP1), demonstrates the potential for the development of anti-cancer drugs utilizing this mechanism.
	12. 168 Accesses	Research article HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen, Thomas E Smithgall BMC Chemical Biology 2012, 12:1 (15 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Binding of HIV-1 Nef induces conformational change in the ATP-binding site of Hck, making it more susceptible to pharmacological inhibition and thus validating the Nef-Hck signalling pathway as an antiretroviral drug target.
	13. 166 Accesses	Research article MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages Vummidigiridhar Premkumar, Moul Dey, Ruth Dorn, Ilya Raskin BMC Chemical Biology 2010, 10:3 (12 April 2010) Abstract \| Full text \| PDF \| PubMed
	14. 151 Accesses	Research article Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh, Paramvir S Ahuja BMC Chemical Biology 2011, 11:1 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Autoclaving modifies the structure of the amino acid L-glutamine, synthesizing the compounds 5-oxo proline and alpha-amino glutarimide, the latter of which is able to facilitate the infection of a number of resistant plants by Agrobacterium.
	15. 128 Accesses	Research article Dietary phenethylisothiocyanate attenuates bowel inflammation in mice Moul Dey, Peter Kuhn, David Ribnicky, VummidiGiridhar Premkumar, Kenneth Reuhl, Ilya Raskin BMC Chemical Biology 2010, 10:4 (27 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary PEO, an essential oil containing phenethylisothiocyanate, is shown in a mouse model to attenuate bowel inflammation, with expression analyses suggesting suppression of STAT1 transcription as a possible mechanism.
	16. 113 Accesses	Research article Electronic properties of amino acid side chains: quantum mechanics calculation of substituent effects Donard S Dwyer BMC Chemical Biology 2005, 5:2 (3 August 2005) Abstract \| Full text \| PDF \| PubMed
	17. 112 Accesses	Research article Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C₁ Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf, William S Saunders BMC Chemical Biology 2010, 10:1 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Non-cancer cell lines escape mitotic arrest after treatment with the anti-tubulin agent, disorazole C1, in a cyclin-B-dependent and p53-independent manner, but cancer cell lines undergo apoptosis, indicating that this compound might have therapeutic potential to treat cancer.
	18. 112 Accesses	Research article Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners Jianwen Fang, Yakov M Koen, Robert P Hanzlik BMC Chemical Biology 2009, 9:5 (12 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteins with high lysine content and high turnover are more susceptible to covalent modification by xenobiotic reactive metabolites, and an analysis of directly-interacting partners of the most common known targets suggests how adduction has toxic effects.
	19. 112 Accesses	Software DG-AMMOS: A New tool to generate 3D conformation of small molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening David Lagorce, Tania Pencheva, Bruno O Villoutreix, Maria A Miteva BMC Chemical Biology 2009, 9:6 (13 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A fast, automated and reliable program for generating the 3D conformation of small molecules facilitates the preparation of compounds for the in silico screening methods of drug discovery.
	20. 110 Accesses	Research article An informatics search for the low-molecular weight chromium-binding peptide Deendayal Dinakarpandian, Vincent Morrissette, Shveta Chaudhary, Kambiz Amini, Brian Bennett, J David Van Horn BMC Chemical Biology 2004, 4:2 (16 December 2004) Abstract \| Full text \| PDF \| PubMed \| 1 comment
	21. 92 Accesses	Research article Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8:3 (22 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The analysis of separate components of cellular growth dynamics allows a sophisticated assessment of the effect of drug-drug and drug-gene interactions upon cells, and may help characterize the physiological impact of orphan bioactive compounds.
	22. 89 Accesses	Research article Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells Delina Montes-Sánchez, Jose Ventura, Irma Mitre, Susana Frías, Layla Michán, Aurora Espejel-Nuñez, Felipe Vadillo-Ortega, Alejandro Zentella BMC Chemical Biology 2009, 9:7 (22 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Treatment of primary human endothelial cells with tumoral soluble factors induces a pro-adhesive endothelial phenotype and the expression of three new isoforms of the cell adhesion molecule VCAM-1, which could serve as markers of metastasis.
	23. 86 Accesses	Methodology article Chemical tools selectively target components of the PKA system Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9:3 (12 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary New synthetic analogs of cyclic AMP (cAMP) can be used for affinity enrichment and purification of cAMP-dependent protein kinase (PKA) and other cAMP binding proteins and also have potential for other applications in chemical proteomics.
	24. 79 Accesses	Research article Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova, Andrew I Su BMC Chemical Biology 2009, 9:2 (16 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	25. 73 Accesses	Research article Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH₃)Cl₂where L = 3-hydroxypyridine and 2,3-diaminopyridine Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale, Keith Fisher BMC Chemical Biology 2006, 6:3 (13 March 2006) Abstract \| Full text \| PDF \| PubMed