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Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
Maralinganadoddi Sadashiva, Basappa, Shivananju NanjundaSwamy, Feng Li, Kanjoormana Manu, Murugan Sengottuvelan, Doddakunche Prasanna, Nirvanappa Anilkumar, Gautam Sethi, Kazuyuki Sugahara, Kanchugarakoppal Rangappa BMC Chemical Biology 2012, 12:5 (3 October 2012)
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Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen
Tong Shi, Ju Bao, Nick X Wang, Jie Zheng, Dianqing Wu BMC Chemical Biology 2012, 12:4 (14 May 2012)
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High toxicity and specificity of the saponin 3-GlcA-28-AraRhaxyl-medicagenate, from Medicago truncatula seeds, for Sitophilus oryzae
Pedro Da Silva, Vanessa Eyraud, Maïté Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer, Frédéric Gressent BMC Chemical Biology 2012, 12:3 (26 April 2012)
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Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications
Hiroki Kobayashi, Hiroko Harada, Masaomi Nakamura, Yushi Futamura, Akihiro Ito, Minoru Yoshida, Shun-ichiro Iemura, Kazuo Shin-ya, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Masaya Imoto, Yasubumi Sakakibara BMC Chemical Biology 2012, 12:2 (5 April 2012)
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HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen, Thomas E Smithgall BMC Chemical Biology 2012, 12:1 (15 March 2012)
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Editor’s summary
Binding of HIV-1 Nef induces conformational change in the ATP-binding site of Hck, making it more susceptible to pharmacological inhibition and thus validating the Nef-Hck signalling pathway as an antiretroviral drug target.
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Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites
Fazlurrahman Khan, Dhan Prakash, RK Jain BMC Chemical Biology 2011, 11:2 (23 November 2011)
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A simple and rapid high performance liquid chromatography (HPLC) based method for the determination of polychlorinated fungicides such as PCNB, HCB and their possible intermediates provides good recovery, peak resolution and sensitivity without internal interference.
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Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound
Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh, Paramvir S Ahuja BMC Chemical Biology 2011, 11:1 (31 May 2011)
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Editor’s summary
Autoclaving modifies the structure of the amino acid L-glutamine, synthesizing the compounds 5-oxo proline and alpha-amino glutarimide, the latter of which is able to facilitate the infection of a number of resistant plants by Agrobacterium.
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The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds
Nicolas Puillandre, Mandë Holford BMC Chemical Biology 2010, 10:7 (17 September 2010)
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Chemical-genetic profile analysis of five inhibitory compounds in yeast
Md Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi, Ashkan Golshani BMC Chemical Biology 2010, 10:6 (6 August 2010)
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Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility
Courtney R LaValle, Karla Bravo-Altamirano, Karthik V Giridhar, Jun Chen, Elizabeth Sharlow, John S Lazo, Peter Wipf, Q Jane Wang BMC Chemical Biology 2010, 10:5 (5 May 2010)
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Dietary phenethylisothiocyanate attenuates bowel inflammation in mice
Moul Dey, Peter Kuhn, David Ribnicky, VummidiGiridhar Premkumar, Kenneth Reuhl, Ilya Raskin BMC Chemical Biology 2010, 10:4 (27 April 2010)
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Editor’s summary
PEO, an essential oil containing phenethylisothiocyanate, is shown in a mouse model to attenuate bowel inflammation, with expression analyses suggesting suppression of STAT1 transcription as a possible mechanism.
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MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages
Vummidigiridhar Premkumar, Moul Dey, Ruth Dorn, Ilya Raskin BMC Chemical Biology 2010, 10:3 (12 April 2010)
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NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy, Charles Brenner BMC Chemical Biology 2010, 10:2 (22 February 2010)
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Editor’s summary
Quantifying the NAD+ metabolome in two different conditions that extend yeast lifespan indicates that NAD+ precursor vitamins and calorie restriction may extend lifespan by different mechanisms and that ratios of NAD+ metabolites may not underlie the mechanism of calorie restriction.
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Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1
Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf, William S Saunders BMC Chemical Biology 2010, 10:1 (11 February 2010)
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Non-cancer cell lines escape mitotic arrest after treatment with the anti-tubulin agent, disorazole C1, in a cyclin-B-dependent and p53-independent manner, but cancer cell lines undergo apoptosis, indicating that this compound might have therapeutic potential to treat cancer.
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Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells
Delina Montes-Sánchez, Jose Ventura, Irma Mitre, Susana Frías, Layla Michán, Aurora Espejel-Nuñez, Felipe Vadillo-Ortega, Alejandro Zentella BMC Chemical Biology 2009, 9:7 (22 November 2009)
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Editor’s summary
Treatment of primary human endothelial cells with tumoral soluble factors induces a pro-adhesive endothelial phenotype and the expression of three new isoforms of the cell adhesion molecule VCAM-1, which could serve as markers of metastasis.
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DG-AMMOS: A New tool to generate 3D conformation of small molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening
David Lagorce, Tania Pencheva, Bruno O Villoutreix, Maria A Miteva BMC Chemical Biology 2009, 9:6 (13 November 2009)
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Editor’s summary
A fast, automated and reliable program for generating the 3D conformation of small molecules facilitates the preparation of compounds for the in silico screening methods of drug discovery.
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Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners
Jianwen Fang, Yakov M Koen, Robert P Hanzlik BMC Chemical Biology 2009, 9:5 (12 June 2009)
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Proteins with high lysine content and high turnover are more susceptible to covalent modification by xenobiotic reactive metabolites, and an analysis of directly-interacting partners of the most common known targets suggests how adduction has toxic effects.
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Local and global modes of drug action in biochemical networks
Jean-Marc Schwartz, Jose C Nacher BMC Chemical Biology 2009, 9:4 (7 April 2009)
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The effect of different drugs on metabolic interaction networks varies in scope from localized to systemic, supporting the use of a system-wide approach when exploring drug actions.
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Chemical tools selectively target components of the PKA system
Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9:3 (12 February 2009)
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Editor’s summary
New synthetic analogs of cyclic AMP (cAMP) can be used for affinity enrichment and purification of cAMP-dependent protein kinase (PKA) and other cAMP binding proteins and also have potential for other applications in chemical proteomics.
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Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus
John Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova, Andrew I Su BMC Chemical Biology 2009, 9:2 (16 January 2009)
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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
Patrick Chène, Joëlle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz, Thomas Radimerski BMC Chemical Biology 2009, 9:1 (7 January 2009)
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Editor’s summary
The discovery of a novel catalytic inhibitor of human topoisomerase II ATPase activity, quinonoline aminopurine compound 1 (QAP1), demonstrates the potential for the development of anti-cancer drugs utilizing this mechanism.
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Chemogenetic fingerprinting by analysis of cellular growth dynamics
Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8:3 (22 August 2008)
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Editor’s summary
The analysis of separate components of cellular growth dynamics allows a sophisticated assessment of the effect of drug-drug and drug-gene interactions upon cells, and may help characterize the physiological impact of orphan bioactive compounds.
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Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II
Maria Olofsson, Aleksandra Havelka, Slavica Brnjic, Maria C Shoshan, Stig Linder BMC Chemical Biology 2008, 8:2 (1 August 2008)
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Editor’s summary
Inducing apoptosis using compounds screened from a chemical library demonstrates that calcium signaling is generally not an early event and suggests that the calmodulin kinase II pathway is often important in sustaining apoptosis.
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Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae
Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8:1 (7 January 2008)
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Editor’s summary
Endomembrane protein traffic in budding yeast cells is affected by the synthetic sorting inhibitor Sortin2, indicating the mechanism by which Sortin2 disrupts vacuolar delivery and pointing to protein sorting roles for fifteen genes of unknown function.
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Enhancement of intracellular γ-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation
Yuichiro Tanaka, Leslie Wood, Robert V Cooney BMC Chemical Biology 2007, 7:2 (3 July 2007)
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