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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Matthew Kaiser, PhD
Welcome to BMC Chemical Biology published by BioMed Central
BMC Chemical Biology is an open access journal publishing original peer-reviewed research articles in the application of chemistry to the investigation of biological processes and systems including the biosynthesis and metabolism of natural compounds, drug design and complex molecular rearrangements occurring in living organisms.
BMC Chemical Biology (ISSN 1472-6769) is indexed/tracked/covered by PubMed, BIOSIS, CAS, Scopus, EMBASE and Google Scholar.
BMC Chemical Biology 2009, 9 :4
The effect of different drugs on metabolic interaction networks varies in scope from localized to systemic, supporting the use of a system-wide approach when exploring drug actions.
BMC Chemical Biology 2009, 9 :3
New synthetic analogs of cyclic AMP (cAMP) can be used for affinity enrichment and purification of cAMP-dependent protein kinase (PKA) and other cAMP binding proteins and also have potential for other applications in chemical proteomics.
BMC Chemical Biology 2009, 9 :1
The discovery of a novel catalytic inhibitor of human topoisomerase II ATPase activity, quinonoline aminopurine compound 1 (QAP1), demonstrates the potential for the development of anti-cancer drugs utilizing this mechanism.
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Research article
Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners Fang Jianwen, Yakov M Koen, Robert P Hanzlik BMC Chemical Biology 2009, 9 :5 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Local and global modes of drug action in biochemical networks Jean-Marc Schwartz, Jose C Nacher BMC Chemical Biology 2009, 9 :4 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Chemical tools selectively target components of the PKA system Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9 :3 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie B BMC Chemical Biology 2009, 9 :2 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Ch BMC Chemical Biology 2009, 9 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8 :3 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria H BMC Chemical Biology 2008, 8 :2 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Enhancement of intracellular Yuichiro Tanaka, Leslie A Lesoon Wood, Robert V Cooney BMC Chemical Biology 2007, 7 :2 (3 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
The effect of amino acid deletions and substitutions in the longest loop of GFP Gabriela Flores-Ram BMC Chemical Biology 2007, 7 :1 (26 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
ResBoost: characterizing and predicting catalytic residues in enzymes Ron Alterovitz, Aaron Arvey, Sriram Sankararaman, Carolina Dallett, Yoav Freund, Kimmen Sjolander BMC Bioinformatics 2009, 10 :197 (27 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM) Teresa WM Fan, Andrew N Lane, Richard M Higashi, Mohamed A Farag, Hong Gao, Michael Bousamra, Donald M Miller Molecular Cancer 2009, 8 :41 (26 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Antimalarial activity of a cis-terpenone DC Ghislaine Mayer, Maimuna Bruce, Olga Kochurova, Jennifer K Stewart, Qibing Zhou Malaria Journal 2009, 8 :139 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Accuracy and limitations of equations for predicting of the glomerular filtration rate during follow-up of patients with non-diabetic nephropathies Guy Rostoker, Pierre Andrivet, Isabelle Pham, Mireille Griuncelli, Serge Adnot BMC Nephrology 2009, 10 :16 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol Thirunavukkarasu Annamalai, Neil Dani, Bokun Cheng, Yuk-Ching Tse-Dinh BMC Biochemistry 2009, 10 :18 (11 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery Serena Cervantes, Jacques Prudhomme, David Carter, Krishna G Gopi, Qian Li, Young-Tae Chang, Karine G Le Roch BMC Cell Biology 2009, 10 :45 (10 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Overexpression and simple purification of the Thermotoga maritima 6-phosphogluconate dehydrogenase in Escherichia coli and its application for NADPH regeneration Yiran Wang, Y-H Percival Zhang Microbial Cell Factories 2009, 8 :30 (4 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia Scott F Cummins, Dirk Erpenbeck, Zhihua Zou, Charles Claudianos, Leonid L Moroz, Gregg T Nagle, Bernard M Degnan BMC Biology 2009, 7 :28 (4 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Short Communication
Two-stimuli manipulation of a biological motor Zorica Ristic, Marco Vitali, Alessandro Duci, Christian Goetze, Klaus Kemnitz, Werner Zuschratter, Holger Lill, Dirk Bald Journal of Nanobiotechnology 2009, 7 :3 (15 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research
Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells Davy CW Lee, Cindy LH Yang, Stanley CC Chik, James CB Li, Jian-hui Rong, Godfrey CF Chan, Allan SY Lau Journal of Translational Medicine 2009, 7 :34 (14 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
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