Image of the Month - September 2007

GSK-3 inhibitor treatment increases inter-kinetochore distance in DLD-1 cells.
The treatment also increases the incidence of unaligned chromosomes and abnormal metaphase spindles, all pointing to a role for glycogen synthase kinase-3 (GSK-3) in accurate chromosome segregation. GSK-3 inhibitor treated DLD-1 (Human colon adenocarcinoma) cells were fixed and stained to show kinetochore-microtubule interactions and spindle morphology. Centromeres are stained in red, kinetochores (BubR1) in green, and microtubules in blue.

Taken from: Tighe et al., BMC Cell Biology 2007, 8:34 [View article]

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