Novel mouse protein that localizes to acrosome and sperm tail
Cytoplasmic localization of a mouse acrosomal protein, MAST, that is expressed specifically in all cell types in normal testis. In this image pre-immune serum was used as negative control and Propidium Iodide was the counterstain. Here shown in the subfertile testis of Yq-del mice there is a substantial reduction in signal, indicating either reduced expression or alternatively lack of localization to the correct locus. MAST does not contain any known motifs for protein interactions; yet it complexes with calcium-binding proteins localizing to the acrosome. The misexpression of all the proteins identified in a complex in the Yq-del mice invokes the hypothesis of a putative pathway regulated by the Y chromosome. The role of Y chromosome in the regulation of this complex is however not clear from the current study.
Taken from: rachel jesudasan et al., 2013, BMC Cell Biology [View article]