Activated p38 MAPK localizes to regions occupied by cilia in S. mansoni miracidia
The localization and activation pattern of p38, a member of the MAPK family of kinases, is investigated in the larvae (miracidia) of a platyhelminth parasite, Schistosoma mansoni. By using antibodies that specifically detect the activated form of p38 MAPK, it is shown that the protein localizes to the shafts of cilia at the surface of miracidia and that p38 MAPK activity inversely correlates with cilia beat frequency. Shown is the immunolocalization of activated p38 MAPK (green) in a S. mansoni miracidium, still trapped in its egg (red autofluorescence), following fixing and staining of parasites with anti-phospho p38 MAPK primary antibodies.
This information is for Figure 3, part J
Taken from: Anthony Walker et al., 2011, BMC Cell Biology [View article]
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