Optineurin regulates endocytic trafficking by localizing to recycling endosomes
A mutant of optineurin, E50K, forms large vesicle-like structures (green), which co-localize (yellow) with the transferrin receptor (red). The E50K mutant was overexpressed in HeLa cells, and both the mutant optineurin and endogenous transferrin receptor were visualized by indirect immunofluoroscence staining. Cell staining was examined by confocal microscopy.
Taken from: Ghanshyam Swarup et al., 2010, BMC Cell Biology [View article]
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