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Genetics, genomics and epigenetics

This section considers articles on all aspects of genome-scale analysis, functional genomics, genetic association studies, pharmacogenomics and epigenetics in relation to cancer biology, diagnosis and therapy.

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81.

Research article   Open Access Highly Accessed

Clinicopathologic and gene expression parameters predict liver cancer prognosis

Ke Hao, John Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Eugene Chudin, Nikki P Lee, Mao Mao, Hua Zhong, Danielle Greenawalt, Mark D Ferguson, Irene O Ng, Pak C Sham, Ronnie T Poon, Cliona Molony, Eric E Schadt, Hongyue Dai, John M Luk BMC Cancer 2011, 11:481 (9 November 2011)

Abstract | Full text | PDF | PubMed

82.

Research article   Open Access

Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study

Nicolas Samartzis, Patrick Imesch, Konstantin J Dedes, Eleftherios P Samartzis, André Fedier, Daniel Fink, Rosmarie Caduff, Mathias K Fehr BMC Cancer 2011, 11:463 (26 October 2011)

Abstract | Full text | PDF | PubMed

83.

Research article   Open Access Highly Accessed

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

Masashi Tatsukawa, Akinobu Takaki, Hidenori Shiraha, Kazuko Koike, Yoshiaki Iwasaki, Haruhiko Kobashi, Shin-Ichi Fujioka, Kohsaku Sakaguchi, Kazuhide Yamamoto BMC Cancer 2011, 11:458 (21 October 2011)

Abstract | Full text | PDF | PubMed

84.

Case report   Open Access Highly Accessed

Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma

Geir Hjortland, Leonardo A Meza-Zepeda, Klaus Beiske, Anne H Ree, Siri Tveito, Hanne Hoifodt, Per J Bohler, Knut H Hole, Ola Myklebost, Oystein Fodstad, Sigbjorn Smeland, Eivind Hovig BMC Cancer 2011, 11:455 (20 October 2011)

Abstract | Full text | PDF | PubMed

85.

Research article   Open Access Highly Accessed

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Stefan Enroth, Alvaro Rada-Iglesisas, Robin Andersson, Ola Wallerman, Alkwin Wanders, Lars Påhlman, Jan Komorowski, Claes Wadelius BMC Cancer 2011, 11:450 (19 October 2011)

Abstract | Full text | PDF | PubMed

86.

Research article   Open Access

Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue

Patrizio Castagnola, Davide Malacarne, Paola Scaruffi, Massimo Maffei, Alessandra Donadini, Emanuela Di Nallo, Simona Coco, Gian Tonini, Monica Pentenero, Sergio Gandolfo, Walter Giaretti BMC Cancer 2011, 11:445 (13 October 2011)

Abstract | Full text | PDF | PubMed

87.

Research article   Open Access

DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study

Bernd Frank, Heiko Müller, Melanie Weck, Norman Klopp, Thomas Illig, Elke Raum, Hermann Brenner BMC Cancer 2011, 11:440 (11 October 2011)

Abstract | Full text | PDF | PubMed

88.

Research article   Open Access

Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

Helgi Birgisson, Ulrik Wallin, Lars Holmberg, Bengt Glimelius BMC Cancer 2011, 11:438 (11 October 2011)

Abstract | Full text | PDF | PubMed

89.

Research article   Open Access Highly Accessed

A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence

Patricia P Reis, Levi Waldron, Bayardo Perez-Ordonez, Melania Pintilie, Natalie Galloni, Yali Xuan, Nilva K Cervigne, Giles C Warner, Antti A Makitie, Colleen Simpson, David Goldstein, Dale Brown, Ralph Gilbert, Patrick Gullane, Jonathan Irish, Igor Jurisica, Suzanne Kamel-Reid BMC Cancer 2011, 11:437 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Expression of a four-gene signature in histologically normal surgical margins is associated with oral squamous cell carcinoma recurrence, suggesting that a molecular test could potentially be developed to identify patients at a higher risk of local recurrence.

90.

Research article   Open Access Highly Accessed

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

Eleonor Olsson, Gabriella Honeth, Pär-Ola Bendahl, Lao H Saal, Sofia Gruvberger-Saal, Markus Ringnér, Johan Vallon-Christersson, Göran Jönsson, Karolina Holm, Kristina Lövgren, Mårten Fernö, Dorthe Grabau, Åke Borg, Cecilia Hegardt BMC Cancer 2011, 11:418 (29 September 2011)

Abstract | Full text | PDF | PubMed

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