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Genetics, genomics and epigenetics

This section considers articles on all aspects of genome-scale analysis, functional genomics, genetic association studies, pharmacogenomics and epigenetics in relation to cancer biology, diagnosis and therapy.

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1.

Research article   Open Access

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain)

Pilar Blay, Iñigo Santamaría, Ana S Pitiot, María Luque, Marta G Alvarado, Ana Lastra, Yolanda Fernández, Ángeles Paredes, José MP Freije, Milagros Balbín BMC Cancer 2013, 13:243 (17 May 2013)

Abstract | Provisional PDF

2.

Research article   Open Access

Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population

Tianbo Jin, Xiaolan Li, Jiayi Zhang, Hong Wang, Tingting Geng, Gang Li, Guodong Gao, Chao Chen BMC Cancer 2013, 13:236 (12 May 2013)

Abstract | Full text | PDF | PubMed

3.

Research article   Open Access

Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility

Peng Zhao, Peng Zou, Lin Zhao, Wei Yan, Chunsheng Kang, Tao Jiang, Yongping You BMC Cancer 2013, 13:234 (10 May 2013)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access

Age dependence of tumor genetics in unfavorable neuroblastoma: arrayCGH profiles of 34 consecutive cases, using a Swedish 25-year neuroblastoma cohort for validation

Cihan Cetinkaya, Tommy Martinsson, Johanna Sandgren, Catarina Träger, Per Kogner, Jan Dumanski, Teresita Díaz de Ståhl, Fredrik Hedborg BMC Cancer 2013, 13:231 (9 May 2013)

Abstract | Provisional PDF | PubMed

5.

Research article   Open Access

Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

Alexa J Resler, Kathleen E Malone, Lisa G Johnson, Mari Malkki, Effie W Petersdorf, Barbara McKnight, Margaret M Madeleine BMC Cancer 2013, 13:219 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

Technical advance   Open Access

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection

Giada V Zapparoli, Robert N Jorissen, Chelsee A Hewitt, Michelle McBean, David A Westerman, Alexander Dobrovic BMC Cancer 2013, 13:206 (24 April 2013)

Abstract | Provisional PDF | PubMed

7.

Research article   Open Access

Impact of KRAS, BRAF and PI3KCA mutations in rectal carcinomas treated with neoadjuvant radiochemotherapy and surgery

Olfa Derbel, Qing Wang, Françoise Desseigne, Michel Rivoire, Pierre Meeus, Patrice Peyrat, Mattia Stella, Isabelle Martel-Lafay, Anne-Isabelle Lemaistre, Christelle de La Fouchardière BMC Cancer 2013, 13:200 (23 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research article   Open Access

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Masao Honda, Taro Yamashita, Tatsuya Yamashita, Kuniaki Arai, Yoshio Sakai, Akito Sakai, Mikiko Nakamura, Eishiro Mizukoshi, Shuichi Kaneko BMC Cancer 2013, 13:191 (15 April 2013)

Abstract | Provisional PDF | PubMed

9.

Case report   Open Access

TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

Juliana Giacomazzi, Simone Selistre, Juliana Duarte, Jorge Pinto Ribeiro, Paulo JC Vieira, Gabriel de Souza Macedo, Cristina Rossi, Mauro Czepielewski, Cristina Brinkmann Oliveira Netto, Pierre Hainaut, Patricia Ashton-Prolla BMC Cancer 2013, 13:187 (9 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research article   Open Access Highly Accessed

Expressional alterations in functional ultra-conserved non-coding rnas in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells

Karen M Watters, Kenneth Bryan, Niamh H Foley, Maria Meehan, Raymond L Stallings BMC Cancer 2013, 13:184 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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