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Experimental therapeutics and drug development Section edited by John Hartley

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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1.

Research article   Open Access

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Peter H Cashin, Haile Mahteme, Wilhelm Graf, Henning Karlsson, Rolf Larsson, Peter Nygren BMC Cancer 2013, 13:435 (24 September 2013)

Abstract | Full text | PDF | PubMed

2.

Research article   Open Access

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon, Chul-Woo Kim BMC Cancer 2013, 13:421 (17 September 2013)

Abstract | Full text | PDF | PubMed

3.

Research article   Open Access Highly Accessed

Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts

Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry, Brooke T Mossman BMC Cancer 2013, 13:400 (11 September 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Silica microparticles loaded with doxorubicin (DOX) and modified with a mesothelin specific antibody demonstrate higher effectiveness and lower toxicity than DOX systemic treatment in a mouse xenograft model of human peritoneal mesothelioma.

4.

Research article   Open Access

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors

Mercè Juliachs, August Vidal, Xavier del Muro, Josep M Piulats, Enric Condom, Oriol Casanovas, Mariona Graupera, Jose R Germà, Alberto Villanueva, Francesc Viñals BMC Cancer 2013, 13:382 (10 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research article   Open Access

Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

Reza Mokhtari, Sushil Kumar, Syed S Islam, Mehrdad Yazdanpanah, Khosrow Adeli, Ernest Cutz, Herman Yeger BMC Cancer 2013, 13:378 (8 August 2013)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Mårten Fryknäs, Joachim Gullbo, Xin Wang, Linda Rickardson, Malin Jarvius, Malin Wickström, Saadia Hassan, Claes Andersson, Mats Gustafsson, Gunnar Westman, Peter Nygren, Stig Linder, Rolf Larsson BMC Cancer 2013, 13:374 (6 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

Research article   Open Access Highly Accessed

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

Vita M Golubovskaya, Baotran Ho, Min Zheng, Andrew Magis, David Ostrov, Carl Morrison, William G Cance BMC Cancer 2013, 13:342 (11 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research article   Open Access

Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen

Lars Herfindal, Lene Myhren, Bjørn Gjertsen, Stein Døskeland, Gro Gausdal BMC Cancer 2013, 13:341 (11 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research article   Open Access Highly Accessed

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

Valerie Kedinger, Aline Meulle, Omar Zounib, Marie-Elise Bonnet, Jean-Baptiste Gossart, Elodie Benoit, Melanie Messmer, Pattabhiraman Shankaranarayanan, Jean-Paul Behr, Patrick Erbacher, Anne-Laure Bolcato-Bellemin BMC Cancer 2013, 13:338 (9 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research article   Open Access

Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models

Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Alexander, Cherie-Ann O Nathan BMC Cancer 2013, 13:320 (1 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

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