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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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1.

Research article   Open Access

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

Marieke L Kuijjer, Elisabeth FP Peterse, Brendy EWM van den Akker, Inge H Briaire-de Bruijn, Massimo Serra, Leonardo A Meza-Zepeda, Ola Myklebost, A Bassim Hassan, Pancras CW Hogendoorn, Anne-Marie Cleton-Jansen BMC Cancer 2013, 13:245 (20 May 2013)

Abstract | Provisional PDF

2.

Research article   Open Access

Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells

Christiana Charalambous, Chara A Pitta, Andreas I Constantinou BMC Cancer 2013, 13:238 (15 May 2013)

Abstract | Provisional PDF | PubMed

3.

Research article   Open Access

Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells

Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya, Takashi Joh BMC Cancer 2013, 13:237 (14 May 2013)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access

Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells

Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa, Kazuhito Rokutan BMC Cancer 2013, 13:229 (7 May 2013)

Abstract | Full text | PDF | PubMed

5.

Research article   Open Access

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β

Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita, Hiroshi Iwasaki BMC Cancer 2013, 13:224 (4 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

Research article   Open Access

Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography

Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew, Elizabeth A McNiel BMC Cancer 2013, 13:218 (30 April 2013)

Abstract | Provisional PDF | PubMed

7.

Research article   Open Access Highly Accessed

Evidence for tankyrases as antineoplastic targets in lung cancer

Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky, Sarah J Freemantle BMC Cancer 2013, 13:211 (28 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research article   Open Access

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy, Fuyuhiko Tamanoi BMC Cancer 2013, 13:198 (22 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research article   Open Access

A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus, Manuel L Penichet BMC Cancer 2013, 13:195 (17 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research article   Open Access

Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer

Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks, C Max Schmidt BMC Cancer 2013, 13:194 (17 April 2013)

Abstract | Provisional PDF | PubMed

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